Covid19-Sources

Background Annexin A2 is a phospholipid-binding protein involved in fibrinolysis, cell membrane stabilization and repair, and ensuring the integrity of the pulmonary microvasculature. Given the autoantibodies observed in COVID-19 and that Annexin A2 is a known target of antiphospholipid antibodies, we studied autoimmunity directed against Annexin A2 among hospitalized COVID-19 patients. Methods We used ELISA to identify the levels of IgG autoantibodies recognizing Annexin A2 and A5 among 86 hospitalized cases of COVID-19. Using logistic regression, we analyzed the association between anti-A...

Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity ...

The number of people with COVID-19 inside ICUs has broken records for 16 consecutive days.

Lockdown policies are thought to reflect the scientific consensus. But how do we measure that consensus? Daniele Fanelli (LSE) set up a site that enables academics to anonymously give their views o…

Background The COVID-19 virus pandemic has caused a significant number of deaths worldwide. If the prevalence of the infection continues to grow, this could impact life expectancy. This paper provides first estimates of the potential direct impact of the COVID-19 pandemic on period life expectancy. Methods From the estimates of bias-adjusted age-specific infection fatality rates in Hubei (China) and a range of six prevalence rate assumptions ranging from 1% to 70%, we built a discrete-time microsimulation model that simulates the number of people infected by COVID-19, the number dying from ...

Prolonged SARS-CoV-2 RNA shedding and recurrence of PCR-positive tests have been widely reported in patients after recovery, yet these patients most commonly are non-infectious[1][1]–[14][2]. Here we investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests. In support of this hypothesis, we found chimeric transcripts consisting of viral fused to cellular sequences in published data sets of SARS-CoV-2 infected cultured cells and primary cells of pat...

The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity. While ne…

Exakt 9118 Corona-Tote in Deutschland weist das Robert-Koch-Institut (RKI) als oberste Behörde für Infektionskrankheiten Stand am Montag aus. Das klingt genau. Ist es aber nicht.

Original Article from The New England Journal of Medicine — Humoral Immune Response to SARS-CoV-2 in Iceland

1300 Covid-Patienten aus allen Altersgruppen und Tausende Überstunden: Die München Klinik zieht eine Corona-Zwischenbilanz.

VACCINE ESCAPE OF VARIANTS vs Pfizer-BioNTech & NIH-Moderna: Troubling new peer-reviewed paper shows even 2-dose recipients have serious trouble neutralizing the #B1351 🇿🇦 variant—as little as vs old SARS & bat coronavirus. #P1 is poor too. 1-dose worse. Lots of graphs🧵 #COVID19 pic.twitter.com/glXBOqMU4l— Eric Feigl-Ding (@DrEricDing) March 14, 2021

Correspondence from The New England Journal of Medicine — Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

New data on @moderna_tx vaccine and variants@NEJM Immune evasion-- neutralizing antibodies:B.1.1.7 (UK): no significant effectP.1 (Brazil) & B.1.427/9 (CA): mild/moderateB.1.351 (S Africa): more pronounced, but still fully neutralized the pseudovirushttps://t.co/CFwJf3nhPG pic.twitter.com/FYOU8guWHc— Eric Topol (@EricTopol) March 17, 2021

Israel: Updated cases, hospitalizations & deaths across age groupsIn people 60 y/o and above, who were vaccinated first, since the peak in mid Jan.:86% fewer cases73% fewer critically ill91% fewer deathsDeclines seen across all age groupsEconomy now nearly fully open pic.twitter.com/tOLE9XsHde— Eran Segal (@segal_eran) March 18, 2021

The evolution of immune evasion in an immunocompromised individual with covid-19: #SARSCoV2 sequenced 10 times over the course of 5 monthshttps://t.co/npjhScgpg2 @CellCellPress https://t.co/BO0lQDyXnf pic.twitter.com/FRCXC92mrm— Eric Topol (@EricTopol) March 16, 2021

Objectives Collate and analyse data of maxillofacial/rhino-cerebro-orbital fungal infections reported during the era of the Covid-19 pandemic, with the aim of investigating the common contributing factors leading to such infections and of highlighting the significance of this surge seen in patients infected with SARS-CoV-2. Method This retrospective observational multi-centric study analysed patient data collected from clinicians belonging to different specialties in Bangalore, India. The data included the presentation and management of patients presenting with aggressive maxillofacial and ...

In Anbetracht der aktuellen Diskussion in deutschen Medien über den angeblich mit "massiven" unerwünschten Arzneimittelwirkungen behafteten, adjuvantierten Impfstoff gegen H1N1 ("Schweinegrippe") stellt sich die Frage, ob typische Nebenwirkungen wie Schmerzen an der Applikationsstelle und Fieber durch gleichzeitige Applikation von Analgetika/Antipyretika vermieden werden können. Insbesondere bei Kindern besteht die Angst, dass impfinduzierte Fieberkrämpfe zur Ausbildung einer Epilepsie in der Adoleszenz führen könnten. Dementsprechend empfehlen einige Länder wie die USA die Gabe von Analget...

Berlin – In seinem Aufklärungsmerkblatt zur Schutzimpfung gegen COVID-19 mit Stand vom 21. Januar 2021 empfiehlt das Robert-Koch-Institut (RKI) unter der... #Studie #Coronaimpfung #Paracetamol #Impfwirkung

(2015). Spontaneous heparin-induced thrombocytopenia syndrome without any proximate heparin exposure, infection, or inflammatory condition: Atypical clinical features with heparin-dependent platelet activating antibodies. Platelets: Vol. 26, No. 6, pp. 602-607.

Author's Original

SARS-CoV-2 lineage B.1.1.7, a variant first detected in the UK in September 20201, has spread to multiple countries worldwide. Several studies have established that B.1.1.7 is more transmissible than preexisting variants, but have not identified whether it leads to any change in disease severity2. Here we analyse a dataset linking 2,245,263 positive SARS-CoV-2 community tests and 17,452 COVID-19 deaths in England from 1 September 2020 to 14 February 2021. For 1,146,534 (51%) of these tests, the presence or absence of B.1.1.7 can be identified because of mutations in this lineage preventing ...

It is important to understand the temporal trend of the paediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load to estimate the transmission potential of children in schools and communities. We determined the differences in SARS-CoV-2 viral load dynamics between nasopharyn …

Our risk model estimates chances of death and hospitalisation based on age, sex and comorbidities

All of the F.D.A.-authorized vaccines offer strong protection against Covid-19, and assessing their efficacy isn’t as simple as a head-to-head comparison.