Covid19-Sources

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COVID-19 has swept across the world, overwhelming healthcare systems and raising countless questions about how best to diagnose patients, treat infections, save lives, and contain the pandemic. In short order, researchers have launched randomized trials to uncover pharmacologic interventions that hold the promise of preventing or lessening the severity of the disease. But getting results takes time. And time was a luxury that doctors on the frontlines of the coronavirus fight could ill afford in the early months of the pandemic. The dangers of COVID-19 present an unprecedented opportunity t...

Wissenschaftler und Ärzte um den Bonner Virologen Hendrik Streeck fordern eine Abkehr von der bisherigen Strategie.

Dreimal so viele Tests wie im Frühjahr und gleichzeitig steigende Neuinfizierten-Zahlen: Gibt es einen Zusammenhang? Experten bezeichnen die Frage nach der Höhe der Dunkelziffer als "Millionen-Frage".

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon et al. mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host fact...

Antibody-dependent enhancement (ADE) has been reported in several virus infections including dengue fever virus, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infection. To study whether ADE is involved in COVID-19 infections, in vitro pseudotyped SARS-CoV-2 entry into Raji cells, K562 cells, and primary B cells mediated by plasma from recovered COVID-19 patients were employed as models. The enhancement of SARS-CoV-2 entry into cells was more commonly detected in plasma from severely-affected elderly patients with high titers of SARS-CoV-2 ...

While the current pandemic remains a thread to human health, the polyclonal nature of the antibody response against SARS-CoV-2 is not fully understood. Other than SARS-CoV-2, humans are susceptible to six different coronaviruses, and previous exposure to antigenically related and divergent seasonal coronaviruses is frequent. We longitudinally profiled the early humoral immune response against SARS-CoV-2 on hospitalized COVID-19 patients, and quantify levels of pre-existing immunity to OC43, HKU1 and 223E seasonal coronaviruses. A strong back-boosting effect to conserved, but not variable re...

BACKGROUND Characterizing the humoral immune response to SARS-CoV-2 and developing accurate serologic assays are needed for diagnostic purposes and estimating population-level seroprevalence. METHODS We measured the kinetics of early antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 in a cohort of 259 symptomatic North American patients infected with SARS-CoV-2 (up to 75 days after symptom onset) compared to antibody levels in 1548 individuals whose blood samples were obtained prior to the pandemic. RESULTS Between 14-28 days from onset of sympto...

WANING ANTIBODIES - Tests on more than 365,000 people in England have shown that the antibody response to the virus that causes COVID-19 wanes over time.

This JAMA Patient Page describes the risk of acquiring the COVID-19 virus associated with air travel, steps that airlines and airports are taking to mitigate risk, and steps that passengers can take to reduce their risk.

Variations in patient defence responses tracked over time.

Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These stu...

Background: BNT162b2 mRNA and ChAdOx1 nCOV-19 adenoviral vector vaccines have been rapidly rolled out in the UK. We determined the factors associated with vacci

Berlin – Die Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI) fordert eine Verlängerung des Lockdowns bis Anfang April.... #COVID-19

Original Article from The New England Journal of Medicine — BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Trois-Rivieres/Kanada – Die Störungen der Chemosensorik, die zu den häufigsten Symptomen von COVID-19 gehören, können noch lange über das Ende der... #Studie #COVID19

There is increasing evidence that adult patients diagnosed with acute COVID-19 suffer from Long COVID initially described in Italy. To date, data on Long COVID in children are lacking. We assessed persistent symptoms in pediatric patients previously diagnosed with COVID-19. More than a half reported at least one persisting symptom even after 120 days since COVID-19, with 42.6% being impaired by these symptoms during daily activities. Symptoms like fatigue, muscle and joint pain, headache, insomnia, respiratory problems and palpitations were particularly frequent, as also described in adults...

Game theory suggests that donating doses can help nations of all income levels.

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Aus aktuellem Anlass noch mal ein paar Erläuterungen zu Viren, Evolution und Virulenz. Zunächst: es ist nicht einfach so, dass ein virulenter (="krankmachender") Erreger automatisch schlecht adaptiert (angepasst) ist. 1/16— Friedemann Weber (@Friedemann1) February 24, 2021

California's homegrown coronavirus strain is more transmissible than its predecessors, is more resistant to vaccines, and may cause more severe cases of COVID-19.

An important unknown during the coronavirus disease-2019 (COVID-19) pandemic has been the infection fatality rate (IFR). This differs from the case fa…

Influenza, Pneumonie oder doch COVID-19? An zwei Fallbeispielen wird eine pragmatische Herangehensweise für die Diagnostik und Behandlung von akuten Atemwegsinfektionen während der anhaltenden SARS-CoV-2-Pandemie aufgezeigt. Die SARS-CoV-2-(„severe...

Oxford – Eine Verlängerung des Intervalls zwischen den beiden Dosierungen, die in Großbritannien praktiziert und in anderen Ländern diskutiert wird, führt beim... #Studie #Coronaimpfstoff #Astrazeneca #Schutzwirkung