Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications | medRxiv
Objective Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect vulnerable age groups. Methods Studies of COVID-19 prevalence were collected by conducting an online search of published articles, preprints, and government reports that were publicly disseminated prior to 18 September 2020. The systematic review encompassed 113 studies, of which 27 studies (covering 34 geographical locations) satisfied the inclusion criteria and were included in the meta-analysis. Age-specific IFRs were computed using the prevalence d...
Australia ends local COVID vaccine trials due to HIV false positives | News | DW | 11.12.2020
The University of Queensland-CSL vaccine trial was terminated amid concerns that it could interfere with HIV diagnosis. The company will now produce more units of rival vaccine AstraZeneca instead.
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy | Science
Among the research tools necessary to develop medical interventions to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, high on the list are informative animal models with which to study viral pathogenesis. Gu et al. developed a mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia. Adaptation of this viral strain in the mouse appeared to be dependent on a critical amino acid change, Asn501 to Tyr (N501Y), within the receptor-binding domain of the viral spike protein. The new mouse model was used...
(1) Jimmy Nelson auf Twitter: "@thereal_truther @FaceLikeTheSun You're flat out wrong mate, you're citing the controllers State Propoganda designed to control your reality and perception, you need to break free from the chains" / Twitter
You're flat out wrong mate, you're citing the controllers State Propoganda designed to control your reality and perception, you need to break free from the chains— Jimmy Nelson (@robinsonjre53) January 4, 2021
(1) Health Nerd auf Twitter: "4/n Fact 3: RT-PCR testing for COVID-19 has a very low rate of false positives. This is both conceptually demonstrable https://t.co/FJugSlHBup And mathematical fact https://t.co/0ulcSm5lI0" / Twitter
4/n Fact 3: RT-PCR testing for COVID-19 has a very low rate of false positives. This is both conceptually demonstrable https://t.co/FJugSlHBupAnd mathematical fact https://t.co/0ulcSm5lI0— Health Nerd (@GidMK) December 22, 2020
(1) Jürgen Witte auf Twitter: "Deutliche #Übersterblichkeit in #Schweden Daten ab 1.4. (vorher kaum Corona Todesfälle) bis 15.12. (danach Daten unvollständig) https://t.co/3Awq0Dk7Ig" / Twitter
Deutliche #Übersterblichkeit in #Schweden Daten ab 1.4. (vorher kaum Corona Todesfälle)bis 15.12. (danach Daten unvollständig) pic.twitter.com/3Awq0Dk7Ig— Jürgen Witte (@jot_witte) January 10, 2021
Mela Eckenfels auf Twitter: "Ein kurzer Thread über die Fixierung der Pandemie-Leugner auf Christian Drostens Doktorarbeit. Daran hat mich nämlich von Beginn an irgendwas gestört, ich konnte nur nicht den Finger drauf legen. Inzwischen denke ich, ich kann es. 1/" / Twitter
Ein kurzer Thread über die Fixierung der Pandemie-Leugner auf Christian Drostens Doktorarbeit. Daran hat mich nämlich von Beginn an irgendwas gestört, ich konnte nur nicht den Finger drauf legen. Inzwischen denke ich, ich kann es. 1/— Mela Eckenfels (@Felicea) January 9, 2021
(7) UnionWatch auf Twitter: "Beim Deutschen Städte- und Gemeindebund #DStGB rechnet man damit, dass es frühestens ab Dezember 2021 (!) #Coronavirus-Impfungen für Menschen unter 60 Jahren gibt. Ach du Scheiße. /MS https://t.co/1AYJnwwMam https://t.co/rk1jh4GbYX" / Twitter
Beim Deutschen Städte- und Gemeindebund #DStGB rechnet man damit, dass es frühestens ab Dezember 2021 (!) #Coronavirus-Impfungen für Menschen unter 60 Jahren gibt.Ach du Scheiße. /MShttps://t.co/1AYJnwwMam pic.twitter.com/rk1jh4GbYX— UnionWatch (@watch_union) December 14, 2020
(7) Matthias Quent auf Twitter: "ℹ️In den vergangenen Tagen gab es in den Medien und in der Politik Thesen darüber, dass Regionen besonders stark von #Corona belastet sind, in denen die #AfD besonders stark ist. Was ist da dran? Wir haben nachgerechnet. Es folgt ein langer #Thread #fehlendermindestabstand⬇️" / Twitter
ℹ️In den vergangenen Tagen gab es in den Medien und in der Politik Thesen darüber, dass Regionen besonders stark von #Corona belastet sind, in denen die #AfD besonders stark ist. Was ist da dran? Wir haben nachgerechnet. Es folgt ein langer #Thread #fehlendermindestabstand⬇️— Matthias Quent (@Matthias_Quent) December 6, 2020
(7) Mela Eckenfels auf Twitter: "Auch, wenn ich mich freue, das meine Recherchen in den "Corman-Drosten-Review" als hilfreich empfunden wurde. Was aber die Diskussion um den Report, um den Test der Charité und auch die PCR-Tests an sich vermissen lässt: Sie ist irrelevant. Das möchte ich versuchen einzuordnen." / Twitter
Auch, wenn ich mich freue, das meine Recherchen in den "Corman-Drosten-Review" als hilfreich empfunden wurde. Was aber die Diskussion um den Report, um den Test der Charité und auch die PCR-Tests an sich vermissen lässt: Sie ist irrelevant. Das möchte ich versuchen einzuordnen.— Mela Eckenfels (@Felicea) December 4, 2020
(7) David Noisternig auf Twitter: "Deutlicher Hinweis dafür, dass schwedische ICUs wieder triagieren. Patienten über 80 wurden in der letzten Woche deutlich weniger aufgenommen als zuletzt. Parallel weiterhin Anstieg in Aufnahmen der anderen Altersgruppen. 😢" / Twitter
Deutlicher Hinweis dafür, dass schwedische ICUs wieder triagieren. Patienten über 80 wurden in der letzten Woche deutlich weniger aufgenommen als zuletzt. Parallel weiterhin Anstieg in Aufnahmen der anderen Altersgruppen. 😢 https://t.co/D15nPVgFVZ— David Noisternig (@DNoisternig) December 9, 2020
(7) Health Nerd auf Twitter: "John Ioannidis, of "Most Published Research Findings Are False" fame, has now had his paper on IFR published Let's do one, final, twitter peer-review on the study 1/n https://t.co/D24ut4zGJj" / Twitter
John Ioannidis, of "Most Published Research Findings Are False" fame, has now had his paper on IFR publishedLet's do one, final, twitter peer-review on the study 1/n pic.twitter.com/D24ut4zGJj— Health Nerd (@GidMK) October 14, 2020
(7) Philipp Hummel auf Twitter: "Weil man jetzt häufiger davon liest, dass die Grippe ganz „mysteriös“ ausgestorben sei: 1) Mir war nicht klar, wie spät die Grippe-Saison ihren Höhepunkt hat. Quelle: https://t.co/hRhV4p6Gk4 https://t.co/6anlM2MaxV" / Twitter
Weil man jetzt häufiger davon liest, dass die Grippe ganz „mysteriös“ ausgestorben sei: 1) Mir war nicht klar, wie spät die Grippe-Saison ihren Höhepunkt hat. Quelle: https://t.co/hRhV4p6Gk4 pic.twitter.com/6anlM2MaxV— Philipp Hummel (@p_humm) December 20, 2020
Corona Mönchengladbach: 15-Jähriger stirbt an Covid-19-Folgen
Der Junge hatte erhebliche Vorerkrankungen. Seit seiner Geburt war er immer wieder wegen Lungenentzündungen und verschiedenen Infektionen im Krankenhaus gewesen. Für ihn hätte jedes Virus tödlich sein können, sagt eine Ärztin.
Es scheint eine recht starke Korrelation zu geben zwischen a) den Landkreisen, in denen die AfD sehr starke Wahlergebnisse erzielt, und b) der 7-Tage-Inzidenz an Corona-Neuinfektionen. Einen solchen Zusammenhang gibt es nur bei der AfD, bei keiner anderen Partei. Von Jürgen Fritz.
Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy - Giovanni Apolone, Emanuele Montomoli, Alessandro Manenti, Mattia Boeri, Federica Sabia, Inesa Hyseni, Livia Mazzini, Donata Martinuzzi, Laura Cantone, Gianluca Milanese, Stefano Sestini, Paola Suatoni, Alfonso Marchianò, Valentina Bollati, Gabriella Sozzi, Ugo Pastorino, 2020
There are no robust data on the real onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and spread in the prepandemic period worldw...
Published Papers and Data on Lockdown Weak Efficacy - and Lockdown Huge Harms — The Fat Emperor
Here collated are the papers of shame - the lockdown ideology is destroying our societal health, selling the lie of saving lives. Lockdowns cost net suffering and lives - by a huge margin. Here we gather together the evidence. TWENTY+ LOCKDOWN LACK OF EFFICACY PAPERS & ANALYSES: STANFORD - ...
Effects of non-pharmaceutical interventions on COVID-19: A Tale of Three Models | medRxiv
Objective To compare the inference regarding the effectiveness of the various non-pharmaceutical interventions (NPIs) for COVID-19 obtained from different SIR models. Study design and setting We explored two models developed by Imperial College that considered only NPIs without accounting for mobility (model 1) or only mobility (model 2), and a model accounting for the combination of mobility and NPIs (model 3). Imperial College applied models 1 and 2 to 11 European countries and to the USA, respectively. We applied these models to 14 European countries (original 11 plus another 3), over tw...
Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy
Severe acute respiratory syndrome (SARS) is a febrile respiratory illness. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus (SARS-CoV), whose genome was recently sequenced. Since it is ...
Frontiers | Covid-19 Mortality: A Matter of Vulnerability Among Nations Facing Limited Margins of Adaptation | Public Health
Context: The human development territories have been severely constrained under the Covid-19 pandemic. A common dynamics has been observed, but its propagation has not been homogeneous over each continent. We aimed at characterizing the non-viral parameters that were most associated with death rate.Methods: We tested major indices from five domains (demography, public health, economy, politics, environment) and their potential associations with Covid-19 mortality during the first 8 months of 2020, through a Principal Component Analysis and a correlation matrix with a Pearson correlation tes...
Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double blind dose response study in Lagos | medRxiv
Introduction In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS - CoV-2 viral replication, but questions remained as to In-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19. Methods We conducted a translational proof of concept (PoC) randomized, double blind placebo controlled, dose response, parallel group study of IV efficacy in RT - PCR proven COVID 19 positive patients. 62 patients were randomized to 3 treatment groups. (A) IV 6mg regime, (B)IV 12 mg regime (given Q84hrs for 2weeks) (C, control) L...
Seven weeks ago, South Korea and the U.S. had the same number of virus deaths. Today, South Korea has fewer than 300, and the U.S. has more than 70,000.
Eurosurveillance | Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.
Background Antigen point of care tests (AgPOCT) can accelerate SARS-CoV-2 testing. As first AgPOCT are becoming available, there is a growing interest in their utility and performance. Methods Here we compare AgPOCT products by seven suppliers: the Abbott Panbio™ COVID-19 Ag Rapid Test; the RapiGEN BIOCREDIT COVID-19 Ag; the Healgen® Coronavirus Ag Rapid Test Cassette (Swab); the Coris Bioconcept Covid.19 Ag Respi-Strip; the R-Biopharm RIDA®QUICK SARS-CoV-2 Antigen; the NAL von minden NADAL COVID19-Ag Test; and the Roche/SD Biosensor SARS-CoV Rapid Antigen Test. Tests were evaluated on reco...