Covid19-Sources

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Risks of Severe Acute Respiratory Syndrome Coronavirus 2 JN.1 Infection and Coronavirus Disease 2019–Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study
Risks of Severe Acute Respiratory Syndrome Coronavirus 2 JN.1 Infection and Coronavirus Disease 2019–Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study
Receipt of updated XBB1.5 vaccines 8-120 days earlier was associated with lower risk of severe acute respiratory syndrome coronavirus 2 infection, emergenc
·academic.oup.com·
Risks of Severe Acute Respiratory Syndrome Coronavirus 2 JN.1 Infection and Coronavirus Disease 2019–Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
COVID-19 leads to a sustained reduction of immune cells of the myeloid and lymphoid cell lineages even 10 months after the first infection. Ten months after the first infection, S- and RBD-specific I...
·onlinelibrary.wiley.com·
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differences in airborne stability of SARS-CoV-2 variants of concern is impacted by alkalinity of surrogates of respiratory aerosol | Journal of The Royal Society Interface
Differences in airborne stability of SARS-CoV-2 variants of concern is impacted by alkalinity of surrogates of respiratory aerosol | Journal of The Royal Society Interface
The mechanistic factors hypothesized to be key drivers for the loss of infectivity of viruses in the aerosol phase often remain speculative. Using a next-generation bioaerosol technology, we report measurements of the aero-stability of several SARS-CoV-2 ...
·royalsocietypublishing.org·
Differences in airborne stability of SARS-CoV-2 variants of concern is impacted by alkalinity of surrogates of respiratory aerosol | Journal of The Royal Society Interface
Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019
Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019
In a randomized trial of standard-risk adults, metformin decreased severe acute respiratory syndrome coronavirus 2 viral loads by an average of 0.56 log10
·academic.oup.com·
Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure
Author summary In this paper, we directly linked SARS-2-S-triggered syncytium formation in the absence of infection with the ensuing induction of cellular senescence and its pathophysiological contribution to heart failure. We propose that both SARS-2-S expression and SARS-2-S protein internalization were sufficient to induce senescence in nonsenescent ACE2-expressing cells. This is important because of the persistent existence of SARS-2-S or extracellular vesicles containing SARS-2-S during the post-acute stages of SARS-CoV-2 infection in human subjects. In searching for the underlying molecular mechanisms determining syncytial fate, the formation of functional MAVS aggregates dependent on RIG-I was observed at an early stage during fusion and regulated the anti-death to senescence fate of SARS-2-S syncytia through the TNFα-TNFR2 axis. We also found impaired cardiac metabolism in SARS-2-S syncytia induced by condensed WNK1. However, syncytium formation or cellular senescence observed with the wild-type fusogenic S protein does not occur with the spike proteins produced by currently approved COVID-19 mRNA vaccines. Importantly, SARS-2-S-exacerbated heart failure could be largely rescued by WNK1 inhibitor, anti-syncytial drug or senolytic agent. Together, we suggest that rescuing metabolism dysfunction in senescent SARS-2-S syncytia should be taken into consideration in individuals with post-acute sequelae of COVID-19 (PASC).
·journals.plos.org·
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure
„Mit“ oder „an“ Covid-19 gestorben? Studie liefert neue Zahlen - WELT
„Mit“ oder „an“ Covid-19 gestorben? Studie liefert neue Zahlen - WELT
Immer wieder gibt es Diskussionen darüber, ob die Menschen „mit“ oder „am“ Coronavirus gestorben sind. Eine Antwort liefert das Covid-19-Autopsie-Register, in dem die deutschlandweiten Obduktionsergebnisse von Corona-Toten erfasst werden. Forscher haben diese nun erstmals ausgewertet.
·welt.de·
„Mit“ oder „an“ Covid-19 gestorben? Studie liefert neue Zahlen - WELT