Covid19-Sources

Nature Microbiology - Characterizing infection, pathogenesis and transmission of BANAL-52 and BANAL-236 in primary respiratory cells, mice and hamsters shows how viruses closely related to...

München – Kinder, die sich wegen des Nachweises von 2 oder mehr Inselzellantikörpern im Blut im Vorstadium der Erkrankung befanden, sind während der Pandemie... #JAMA

A new COVID variant is spreading. Here's what you need to know about the incubation period, symptoms and when to take a test.

Die Inkubationszeit bei Corona dauert aktuell 5 Tage im Durchschnitt. Ada Health erklärt, was das heißt und ob es Unterschiede zur Omikron-Variante gibt.

Berlin/Potsdam – Eine Berliner Verkäuferin hat nach einer Coronaerkrankung erfolglos vor Gericht darum gekämpft, dass diese als Arbeitsunfall anerkannt wird. Es... #COVID19 #Infektion #Arbeitsplatz #Klage #Berlin

The CDC’s wastewater monitoring program has detected a “very high” presence of the virus in nearly half the country

SARS-CoV-2 was first discovered in 2019 and has disseminated throughout the globe to pandemic levels, imposing significant health and economic burdens. Although vaccines against SARS-CoV-2 have been developed, their long-term efficacy and specificity have not been determined, and antiviral drugs remain necessary. Flavonoids, which are commonly found in plants, fruits, and vegetables and are part of the human diet, have attracted considerable attention as potential therapeutic agents due to their antiviral and antimicrobial activities and effects on other biological activities, such as inflammation. This study uses a combination of biochemical, cellular, molecular dynamics, and molecular docking experiments to provide compelling evidence that the flavonoid luteolin (2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one) has antiviral activity against SARS-CoV-2 3-chymotrypsin-like protease (3CLpro) that is synergistically enhanced by magnesium, zinc, and vitamin C. The IC50 of luteolin against 2 µM 3CLpro is 78 µM and decreases 10-fold to 7.6 µM in the presence of zinc, magnesium, and vitamin C. Thermodynamic stability analyses revealed that luteolin has minimal effects on the structure of 3CLpro, whereas metal ions and vitamin C significantly alter the thermodynamic stability of the protease. Interactome analysis uncovered potential host–virus interactions and functional clusters associated with luteolin activity, supporting the relevance of this flavone for combating SARS-CoV-2 infection. This comprehensive investigation sheds light on luteolin's therapeutic potential and provides insights into its mechanisms of action against SARS-CoV-2. The novel formulation of luteolin, magnesium, zinc, and vitamin C may be an effective avenue for treating COVID-19 patients.

Objective To evaluate the personal protective effects of wearing versus not wearing surgical face masks in public spaces on self-reported respiratory symptoms over a 14 day period. Design Pragmatic randomised superiority trial. Setting Norway. Participants 4647 adults aged ≥18 years: 2371 were assigned to the intervention arm and 2276 to the control arm. Interventions Participants in the intervention arm were assigned to wear a surgical face mask in public spaces (eg, shopping centres, streets, public transport) over a 14 day period (mask wearing at home or work was not mentioned). Participants in the control arm were assigned to not wear a surgical face mask in public places. Main outcome measures The primary outcome was self-reported respiratory symptoms consistent with a respiratory infection. Secondary outcomes included self-reported and registered covid-19 infection. Results Between 10 February 2023 and 27 April 2023, 4647 participants were randomised of whom 4575 (2788 women (60.9%); mean age 51.0 (standard deviation 15.0) years) were included in the intention-to-treat analysis: 2313 (50.6%) in the intervention arm and 2262 (49.4%) in the control arm. 163 events (8.9%) of self-reported symptoms consistent with respiratory infection were reported in the intervention arm and 239 (12.2%) in the control arm. The marginal odds ratio was 0.71 (95% confidence interval (CI) 0.58 to 0.87; P=0.001) favouring the face mask intervention. The absolute risk difference was −3.2% (95% CI −5.2% to −1.3%; P

We need open and nuanced discussions about research findings on public health and social interventions It has been both fascinating and disheartening to observe heated debates among academics about the use of face masks and various other covid-19 related issues, particularly on social media and mostly from the UK and North America. Large and vocal parts of the academic community seem to be split into two groups holding completely incompatible views, with each side equally convinced that they are right. This area of contention makes a constructive exchange of views and joint reflection almost unachievable, since facts and research findings have limited impact when positions are fixed from the outset. The lack of nuance from many or most participants, the frequent personal attacks on individuals, and the often harsh wording exchanged makes the discourse on face masks different to what we are typically used to, or aim for, in academia. After receiving several strong responses from researchers and health professionals when they published a study on face masks, the editors of the Annals of …

Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote settings and in children. We compared the measurement of SARS-CoV-2 spike-specific IgG in paired blood samples collected by standard venepuncture (serum) and the hemaPEN microsampling DBS device from children and adults using an established in-house ELISA. A total of 83 participants (10 months to 65 years of age) with paired serum and hemapen samples were included in the analysis; N=41 adults (36 COVID-positive and 5 COVID-negative) and N=42 children (37 COVID positive and 5 COVID-negative). Moderate- to strong-correlations between paired hemaPEN DBS eluates and serum SARS-CoV-2 IgG antibodies for RBD (r=0.9472, P

Welcome to another summer of Covid-19 infections. Here’s what to do to reduce your risk of catching the disease and what to do if you get it.

Die neuen variantenangepassten Covid-19-Impfstoffe von Biontech/Pfizer sind ab 6. August 2024 erstmalig bestellbar, teilte der Deutsche Apothekerverband (D...

Even in those without long COVID.

The COVID-19 pandemic has had an enormous impact on healthcare across the globe. Patients who were severely infected with SARS-CoV-2, the virus causing COVID-19, sometimes became infected with other pathogens, which is termed coinfection. If the ...

Employment levels for workers with a disability have grown in recent years. What might be driving this?

Mice that received antibodies from Long COVID patients showed symptoms including pain and dizziness, a Yale-led study has found.

DMZ – WISSENSCHAFT ¦ Sarah Koller ¦ Eine im April veröffentlichte Studie liefert neue Erkenntnisse über die Wirksamkeit von COVID-19-Impfstoffen bei der Verhinderung von Long COVID-Symptomen und post-COVID-Thromboembolien und kardiovaskulären Komplikationen. Die Studie basierte auf Daten von mehr als 20 Millionen Teilnehmern und wurde von Forschern in Norwegen durchgeführt. Die Ergebnisse zeigen, dass COVID-19-Impfstoffe konsequent Long COVID-Symptome bei Erwachsenen verhindern. Die Studie ergab, dass geimpfte Personen ein signifikant geringeres Risiko haben, Long COVID-Symptome zu entwickeln, im Vergleich zu ungeimpften Personen. Dies gilt unabhängig vom verwendeten Impfstoff (BNT162b2, mRNA-1273 und ChAdOx1). Darüber hinaus wurde festgestellt, dass die Impfung mit einem beliebigen COVID-19-Impfstoff auch das Risiko von post-COVID-Thromboembolien und kardiovaskulären Komplikationen verringert. Dies ist insbesondere in den ersten 180 Tagen nach einer SARS-CoV-2-Infektion der Fall.

This study examines whether an association exists between COVID-19 infection and progression to clinical diabetes among youth with presymptomatic type 1 diabetes.

Clinical disease incidence jumped after infection

Atemwegsinfekte im ersten Halbjahr 2024 häufigste Ursache für Fehlen am Arbeitsplatz

— Pandemic 𓅃 Index (@pan_accindex)

Das Antidiabetikum Metformin schützt einer Studie zufolge vor Long-Covid.

Outpatient treatment with metformin reduced long COVID incidence by about 41%, with an absolute reduction of 4·1%, compared with placebo. Metformin has clinical benefits when used as outpatient treatment for COVID-19 and is globally available, low-cost, and safe.

Nature Communications - After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition with neurological symptoms. Here, the authors show symptom-specific brain...

2023 Übersterblichkeit von über 50 % bei jungen Menschen zwischen 1 und 39 Jahren im Vergleich zur Entwicklung im Zeitraum 2010 bis 2019. Mehrere Forscher vermuten, dass Spätfolgen von die Ursache für den Anstieg sein könnten. — Tove Harris 🕊😷 (@NFMai)

COVID is a slow-moving catastrophe. — David Lingenfelter, PhD (@dlingenfelter)

Verschiedene Impfungen sollen positive Nebenwirkungen haben. Das belegen Daten von Wissenschaftlern. Drei Impfstoffe stehen im Fokus.