Covid19-Sources

COVID-19 infection has worse outcomes in immunocompromised individuals. This includes those with diabetes mellitus, cancer, chronic autoimmune diseases requiring immunomodulatory therapy, and solid-organ transplant recipients on chronic immunosuppression. Using the National Inpatient Sample Database …

Es ist der höchste Krankenstand seit 25 Jahren laut den Krankenkassen. Mehr als drei Wochen pro Jahr fehlten Arbeitnehmer zuletzt im Schnitt. Doch wer zahlt dafür? Und was steht Arbeitnehmern zu? Ein Fachanwalt gibt dazu Auskunft.

Nature Immunology - Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with...

Common as they are, reinfections may have lasting impacts.

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository. Methods RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system. Causal inference methods will be employed to investigate associations between risk factors and pathologic outcomes. Discussion RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.

This cohort study uses data from a US national claims database to assess whether COVID-19 vaccination is associated with herpes zoster infection.

Nature Reviews Cardiology - Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome....

Für viele ist Corona nach der Infektion nicht vorbei: Sie leiden an Long Covid. Eine Expertin erklärt, was sich bei der Behandlung getan hat und wie sich das Erkrankungsrisiko minimieren lässt.

THE recent surge in flu and Covid deaths across Spain has reportedly left many Spanish funeral homes struggling to cope. In the wake of the recent ‘tripandemic’, funeral services across Spain are…

“We cannot ignore the evidence” that Omicron may be evolving into a more severe form of itself, one researcher told Fortune.

BA.2.86 is a recently emerged, highly mutated SARS-CoV-2 variant that spreads in many countries and threatens human health. This study shows that BA.2.86, unlike closely related variants, can enter lung cells with high efficiency and in a TMPRSS2-dependent fashion and is resistant against therapeutic antibodies.

SARS-CoV-2-related pangolin coronavirus GX\_P2V(short\_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses. ### Competing Interest Statement The authors have declared no competing interest.

In allen spanischen Gesundheitseinrichtungen soll wegen zunehmender Atemwegserkrankungen wie Grippe und Corona ab morgen wieder eine Maskenpflicht gelten. Das berichtete der staatliche TV-Sender RTVE gestern Abend unter Berufung auf das Gesundheitsministerium.

Nature Communications - In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic...

Long COVID has afflicted tens of millions globally leaving many previously-healthy persons severely and indefinitely debilitated. The objective here w…

Several new studies reveal that getting multiple COVID vaccine doses provides strong protection against lingering symptoms

NIH News Release: "...findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."

Die Long Covid-Expertin Kathryn Hoffmann fordert in Hinblick auf die Langzeitschäden einer Corona-Erkrankung mehr Prävention ein.

Autonome kardiovaskuläre Dysfunktion beim Post-COVID-19-Syndrom: eine große Belastung für das Gesundheitswesen Eine kardiovaskuläre autonome Dysfunktion (CVAD) ist eine Fehlfunktion des Herz-Kreislauf-Systems, die durch eine gestörte autonome Kontrolle der Kreislaufhomöostase verursacht wird.

Nature Reviews Cardiology - Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome....

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID, is characterized by persistent symptoms after acute SARS-CoV-2 infection that can vary from patient to patient. Here, we present a case s...

Seroprevalence surveys suggest that more than a third and possibly more than half of the global population has been infected with SARS-CoV-2 by early …

Zwei neue Studien: COVID-19 und Influenza können schwere Langzeitfolgen haben, COVID aber häufiger :: Long Covid ist bei geimpften Kindern seltener als bei ungeimpften.

Nature Communications - COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients...

Nature Reviews Microbiology - The need for a balance between pathogen elimination and protection from cellular damage means that the central nervous system (CNS) is a partially protected niche that...

Protection from past infection against re-infection from pre-omicron variants was very high and remained high even after 40 weeks. Protection was substantially lower for the omicron BA.1 variant and declined more rapidly over time than protection against previous variants. Protection from severe disease was high for all variants. The immunity conferred by past infection should be weighed alongside protection from vaccination when assessing future disease burden from COVID-19, providing guidance on when individuals should be vaccinated, and designing policies that mandate vaccination for workers or restrict access, on the basis of immune status, to settings where the risk of transmission is high, such as travel and high-occupancy indoor settings.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection has brought new challenges to the global prevention and control of coronavirus disease 2019 (COVID-19) pandemic; however, current studies suggest that there is still great uncertainty ...

Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching ...

Counterintuitively, SARS-CoV-2 Omicron infection was associated with increased risk of Omicron reinfection in residents of long-term care and retirement homes. Less robust humoral hybrid immune responses in older adults may contribute to risk of Omicron reinfection.