Covid19-Sources

The median number of organ support–free days was 7 for the vitamin C group, compared with 10 for the control group (adjusted proportional odds ratio [OR], 0.88 [95% credible interval [CrI], 0.73 to 1.06]), and the posterior probabilities were 8.6% (efficacy), 91.4% (harm), and 99.9% (futility), the authors said. For patients who were not critically ill and received vitamin C, the median number of organ support–free days was 22, the same as the placebo group.

Nature Communications - The duration of symptomatic COVID-19 and its impacts on health and quality of life are not well understood. In this study, the authors report results from a survey of...

Nature Communications - Evidence from animal models suggest a vital role for mucosal vaccination in inducing protection from coronavirus infection. Here the authors examine the B and T cell...

OBJECTIVE. The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19)

Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), impairs glucose homoeostasis, but experimental evidence that SARS-CoV …

OBJECTIVE. We investigated the incidence of pediatric type 2 diabetes (T2D) in Germany during 2 years of the coronavirus disease 2019 (COVID-19) pandemic (2020–

This study compares body mass index (BMI) of youths during the COVID-19 pandemic with BMI during the same period in 2019 to determine whether they experienced pandemic-related weight gain.

npj Vaccines - A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity

Im Herbst leiden mehr Menschen an Erkältungen, Grippe – und Corona. Was gilt aktuell eigentlich für Beschäftigte mit positivem Corona-Test? Müssen sie zur Arbeit, auch wenn sie symptomfrei sind?

Natarajan et al. perform a longitudinal study of fecal SARS-CoV-2 RNA shedding in patients with mild to moderate COVID-19, revealing that patients can shed RNA for up to 7 months after infection, that shedding is associated with gastrointestinal symptoms, and that the gastrointestinal tract may be infected even after the respiratory infection has cleared.

Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine.

DMZ – FORSCHUNG ¦ Lena Wallner ¦ Die kürzlich veröffentlichte Studie "Viral kinetics of sequential SARS-CoV-2 infections" hat uns spannende Erkenntnisse darüber geliefert, wie aufeinanderfolgende SARS-CoV-2-Infektionen verlaufen. Ein Team von Forschern, darunter Stephen M. Kissler, James A. Hay, Joseph R. Fauver, Christina Mack, Caroline G. Tai, Deverick J. Anderson, David D. Ho, Nathan D. Grubaugh und Yonatan H. Grad, hat diese bemerkenswerte Arbeit durchgeführt. Die Studie konzentrierte sich hauptsächlich darauf, wie sich eine vorherige SARS-CoV-2-Infektion auf den Verlauf späterer Infektionen auswirkt. Die Forscher analysierten beeindruckende 94.812 longitudinale RT-qPCR-Messungen von Abstrichen aus den Nasenvorhöfen und dem Oropharynx. Dabei stießen sie auf 71 Personen, die zwischen dem 11. März 2020 und dem 28. Juli 2022 zwei gut dokumentierte SARS-CoV-2-Infektionen erlebten. Die Ergebnisse dieser Studie sind äußerst aufschlussreich. Im Vergleich zur ersten Infektion zeigte sich, dass die zweite Infektion in der Regel eine kürzere Clearance-Zeit aufwies. Dies bedeutet, dass der Körper das Virus schneller beseitigte. Interessanterweise blieb das relative Verhältnis der Clearance-Zeit einer Person im Vergleich zu anderen, die mit derselben Virusvariante infiziert waren, in beiden Infektionen etwa gleich. Diese Ergebnisse deuten darauf hin, dass eine frühere SARS-CoV-2-Infektion, ähnlich wie eine Impfung, die Dauer nachfolgender akuter SARS-CoV-2-Infektionen hauptsächlich durch die Verkürzung der Clearance-Zeit verkürzt. Darüber hinaus scheint es ein inhärentes Element der Immunantwort oder einen anderen Faktor im Wirtsorganismus zu geben, der die Fähigkeit einer Person zur SARS-CoV-2-Clearance beeinflusst und über aufeinanderfolgende Infektionen hinweg bestehen bleibt. Diese Erkenntnisse sind von großer Bedeutung, da sie unser Verständnis darüber vertiefen, wie Immunität gegen SARS-CoV-2 funktioniert und wie dies den Verlauf von Infektionen beeinflussen kann. Sie könnten auch wichtige Auswirkungen auf klinische und öffentliche Gesundheitsrichtlinien haben. Dennoch müssen wir einige Einschränkungen dieser Studie berücksichtigen. Die untersuchte Kohorte war größtenteils jung, männlich und gesund. Es wurden keine Daten zu anderen Gesundheitsfaktoren erfasst, und die Ergebnisse könnten sich in verschiedenen Bevölkerungsgruppen unterscheiden. Die Forscher betonen die Notwendigkeit weiterer Studien, um ihre Ergebnisse zu bestätigen und die zugrunde liegenden Mechanismen besser zu verstehen. Trotzdem bietet diese Studie wertvolle Einblicke in die Dynamik aufeinanderfolgender SARS-CoV-2-Infektionen und deren Auswirkungen auf die Clearance-Zeit des Virus im Körper. Es wird spannend sein zu sehen, wie diese Erkenntnisse die Entwicklung von Impf- und Behandlungsstrategien beeinflussen werden. Wir können sicher sein, dass weitere Forschung folgen wird, um die Details dieser faszinierenden Entdeckungen zu klären.

The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research - Volume 3 Issue 1

Post-viral syndromes are associated with serotonin reduction, which may contribute to the neurological and cognitive symptoms seen in individuals with Long COVID.

Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) affects extra-respiratory systems, with small-scale studies showing worsened male lower urinary tract symptoms (LUTS) after ...

Nature - Data from acute hospitals in England are used to quantify hospital-acquired SARS-CoV-2 infections, evaluate likely pathways of spread and factors associated with heightened transmission...

The SARS-CoV-2 sublineage BA [...]

Since detection of SARS-CoV-2 in human autopsy tissues by IHC and EM is difficult and frequently incorrect, we propose criteria for a re-evaluation of available data and guidance for further investigations of direct organ effects by SARS-CoV-2.

Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities, however, remain incompletely understood.1,2

Immer mehr Studien belegen, dass COVID-19-Patienten ein deutlich erhöhtes Risiko für Gefäßerkrankungen haben. Blutverdünnern könnten die Sterblichkeit möglicherweise verringern.

Kistler and Bedford examine the genomes of 28 human endemic viruses and estimate that 10 of these viruses are undergoing antigenic evolution. This demonstrates that evasion of antibody detection is not an uncommon evolutionary strategy among the viruses that commonly infect humans.

A Japanese antiviral appears to shorten symptoms and protect against chronic disease. Also, it doesn’t taste like soapy grapefruit.

🇩🇪2023-PROTOKOLLEMIT ANTIMIKROBIELLEN/ANTIVIRALENFÜRLONG-COVID, POST-COVID-SYNDROMPOST-V-SYNDROMME/CFSFIBROMYALGIEPOTS, TACHYKARDIEDYSAUTONOMIEKOGNITIVE BEEINTRÄCHTIGUNG,DEMENZAUTOIMMUNERKRANKUNGUND ANDERE MIT CHRONISCHER MÜDIGKEIT UND SCHMERZENhttps://t.co/N46RJlcztR pic.twitter.com/JQuy18NwlN— Dr. Gustavo Aguirre-Chang (@Aguirre1Gustavo) September 11, 2023

Cell Research - Bacterial coinfections contribute to severe COVID-19 in winter

Signal Transduction and Targeted Therapy - Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy - Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

SARS-CoV-2 has become one of the most studied viruses of the last century. It was assumed that the only possible host for these types of viruses was mammalian eukaryotic cells. Our recent studies show that microorganisms in the human gastrointestinal tract affect the severity of COVID-19 and for the first time provide indications that the virus might replicate in gut bacteria. In order to further support these findings, in the present work, cultures of bacteria from the human microbiome and SARS-CoV-2 were analyzed by electron and fluorescence microscopy. The images presented in this article, in association with the nitrogen (15N) isotope-labeled culture medium experiment, suggest that SARS-CoV-2 could also infect bacteria in the gut microbiota, indicating that SARS-CoV-2 could act as a bacteriophage. Our results add new knowledge to the understanding of the mechanisms of SARS-CoV-2 infection and fill gaps in the study of the interactions between SARS-CoV-2 and non-mammalian cells. These findings could be useful in suggesting specific new pharmacological solutions to support the vaccination campaign.

Nature Communications - In this study, the authors compare the viral kinetics of first and second SARS-CoV-2 infections using data from an occupational surveillance scheme in the National...

CORRELATION has published a new report entitled “COVID-19 vaccine-associated mortality in the Southern Hemisphere” authored by Denis G. Rancourt, Marine Baudin, Joseph Hickey, and Jérém…

Nature Cell Biology - Gioia, Tavella et al. show that severe acute respiratory syndrome coronavirus 2 causes DNA damage through CHK1 degradation and impairs 53BP1 recruitment to DNA lesions. The...