Covid19-Sources

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Meldungen - #ImpfwissenSchützt – Falschinformationen mit Fakten begegnen
Meldungen - #ImpfwissenSchützt – Falschinformationen mit Fakten begegnen
Falschinformationen können sich heutzutage durch das Internet und die sozialen Medien rasend schnell verbreiten. Insbesondere zum Thema Impfen kursieren eine Vielzahl von Falschinformationen und Behauptungen, die wissenschaftlich nicht belegt sind. Falsches Wissen über Impfungen kann zu Verunsicherung und gesundheitlich bedenklichen Entscheidungen führen.
·pei.de·
Meldungen - #ImpfwissenSchützt – Falschinformationen mit Fakten begegnen
Yunlong Richard Cao on Twitter
Yunlong Richard Cao on Twitter
Importantly, we found that BA.2.86 exhibits lower cell infectivity compared to XBB.1.5 and EG.5, which may affect its transmission. The lower infectivity may be contributed by K356T, V483del, and E554K. Note that here the infectivity is measured through pseudovirus assays. (6/n) pic.twitter.com/WOPXIPLOtT— Yunlong Richard Cao (@yunlong_cao) August 31, 2023
·twitter.com·
Yunlong Richard Cao on Twitter
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical interventions. With the emergence of new strains of SARS-CoV-2 with altered transmissibility and immune evasion potential, a critical question is this: how easily can the virus escape neutralizing antibodies (nAbs) targeting the spike RBD? To answer this question, we combined an analysis of the RBD structure-function with an evolutionary modeling framework. Our structure-function analysis revealed that epitopes for RBD-targeting nAbs overlap one another substantially and can be evaded by escape mutants with ACE2 affinities comparable to the wild type, that are observed in sequence surveillance data and infect cells in vitro. This suggests that the fitness cost of nAb-evading mutations is low. We then used evolutionary modeling to predict the frequency of immune escape before and after the widespread presence of nAbs due to vaccines, passive immunization or natural immunity. Our modeling suggests that SARS-CoV-2 mutants with one or two mildly deleterious mutations are expected to exist in high numbers due to neutral genetic variation, and consequently resistance to vaccines or other prophylactics that rely on one or two antibodies for protection can develop quickly -and repeatedly- under positive selection. Predicted resistance timelines are comparable to those of the decay kinetics of nAbs raised against vaccinal or natural antigens, raising a second potential mechanism for loss of immunity in the population. Strategies for viral elimination should therefore be diversified across molecular targets and therapeutic modalities.
·journals.plos.org·
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
Viral kinetics of SARS-CoV-2 following onset of COVID-19 in symptomatic patients infected with the ancestral strain and omicron BA.2 in Hong Kong: a retrospective observational study
Viral kinetics of SARS-CoV-2 following onset of COVID-19 in symptomatic patients infected with the ancestral strain and omicron BA.2 in Hong Kong: a retrospective observational study
The viral kinetics since symptom onset characterised for symptomatic patients with COVID-19 in our study show that previously vaccinated or younger individuals, or those with a milder infection, shed fewer viruses in a shorter period, implying possible transmission dynamics of SARS-CoV-2 and protective mechanisms of vaccination against infection and severe outcomes.
·thelancet.com·
Viral kinetics of SARS-CoV-2 following onset of COVID-19 in symptomatic patients infected with the ancestral strain and omicron BA.2 in Hong Kong: a retrospective observational study
Health misinformation in the US: education plays a particularly important role
Health misinformation in the US: education plays a particularly important role
The KFF provides reliable, accurate, and non-partisan information to help inform health policy in the US. The KFF has just released its 'Health Misinformation Tracking Poll Pilot' examining the public’s media use and trust in sources of health information and measuring the reach of specific false and inaccurate claims surrounding three health-related topics: COVID-19 and
·edzardernst.com·
Health misinformation in the US: education plays a particularly important role
A Quick Update on the BA.2.86 Variant
A Quick Update on the BA.2.86 Variant
This hyper-mutated variant has shown up in many places now, at a time when wastewater and genomic surveillance is greatly diminished around the world. To date, the BA.2.86 variant has been detected in Israel, Denmark (3 individuals), the UK, the US (2 individuals, one coming back from Japan), and South Africa (2 individuals). It has also been detected in wastewater in 1 region is Switzerland (2% level), along with wastewater detection in Ohio and in Thailand. It’s safe say BA.2.86’s presence is widespread across the world at this point.
·erictopol.substack.com·
A Quick Update on the BA.2.86 Variant
Dr. Christian Kroener 📯 on Twitter
Dr. Christian Kroener 📯 on Twitter
Es gibt bei Ärzten noch große Verwirrung bezüglich #Paxlovid, der Tablettentherapie für Risikopatienten mit Coronainfektion.Bitte bei richtigen Indikation mutig verordnen! Man muss nur Medikamenten Wechselwirkungen beachten und umbasteln!Ein Thread: 1/x#impfluencer pic.twitter.com/zNoc8wutCm— Dr. Christian Kroener 📯 (@Chrissip81) March 17, 2022
·twitter.com·
Dr. Christian Kroener 📯 on Twitter
‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely.
·mdpi.com·
‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding | Proceedings of the National Academy of Sciences
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding | Proceedings of the National Academy of Sciences
The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of ...
·pnas.org·
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding | Proceedings of the National Academy of Sciences
Postacute sequelae of COVID-19 at 2 years
Postacute sequelae of COVID-19 at 2 years
Nature Medicine - Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most...
Fig. 1: Risk of postacute sequelae of COVID-19 up to 2 years after infection by care setting of the acute phase of the disease.Relative risks by days after infection plotted for time periods of 30–90, 91–180, 181–360, 361–540 and 541–720 days after infection, labeled by the last day of the corresponding time period. Heatmaps include (top row) nonhospitalized for COVID-19 during the acute phase of the disease (n = 118,238) corresponding to each sequela and (bottom row) COVID-19 hospitalization during the acute phase of the disease (n = 20,580). Relative risks were estimated in comparison to a noninfected control (n = 5,985,227). Sequelae are grouped by organ system. ACD, acute coronary disease; AIM, abnormal involuntary movements; AKI, acute kidney injury; CKD, chronic kidney disease; DVT, deep vein thrombosis; ESKD, end-stage kidney disease; GAD, general anxiety disorder; GERD, gastroesophageal reflux disease; IBS, irritable bowel syndrome; ICM, ischemic cardiomyopathy; ILD, interstitial lung disease; MI, myocardial infarction; NCD, neurocognitive decline; NICM, nonischemic cardiomyopathy; PTSD, post-traumatic stress disorder; PUD, peptic ulcer disease; TIA, transient ischemic attack; VTE, venous thromboembolism. NS, non-significant.
·nature.com·
Postacute sequelae of COVID-19 at 2 years
Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities
Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities
Counterintuitively, SARS-CoV-2 Omicron infection was associated with increased risk of Omicron reinfection in residents of long-term care and retirement homes. Less robust humoral hybrid immune responses in older adults may contribute to risk of Omicron reinfection.
·thelancet.com·
Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities
Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort
Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort
Post-COVID-19 syndrome (PCS) is characterised by a wide range of symptoms, primarily fatigue and exertion intolerance. While disease courses in the ea…
·sciencedirect.com·
Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort
Eric Topol on Twitter
Eric Topol on Twitter
Two new papers @NatureMedicine and @JAMAInternalMed shed light on #LongCovid at 2-years. But there's no shortage of known unknowns.Reviewed in a new Ground Truths (link in my profile, because that would be it X-suppressed) pic.twitter.com/5CePVxePQa— Eric Topol (@EricTopol) August 21, 2023
·twitter.com·
Eric Topol on Twitter