Covid19-Sources

Gesetzliche Unfallversicherung veröffentlicht Jahresbilanz 2022

A new study has tied suicide rates among children and teenagers directly to the school calendar, suggesting that academic and social stressors can be blamed for an annual increase in fall and spring suicide attempts.

Eine Studie des Robert Koch-Instituts zeigt, dass die Lockdowns in Deutschland wirksam waren. So weit, so klar. Trotzdem fördert die Studie etwas Überraschendes zutage.

This cross-sectional study uses administrative health claims data for emergency department (ED) visits and hospitalizations to examine recent trends in suicidality rates, quantify the seasonality in suicidality, and demonstrate the disrupted seasonality patterns during the spring 2020...

Current Atherosclerosis Reports - COVID-19 is now a global pandemic and the illness affects multiple organ systems, including the cardiovascular system. Long-term cardiovascular consequences of...

“Our findings suggest that once T cells become exhausted, they remain fundamentally ‘wired’ to be exhausted—thus it may be hard to get them to become effective virus- and cancer-fighters again,” said study senior author E. John Wherry, PhD.

Long COVID is associated with multiple symptoms and impairment in multiple organs. Cross- sectional studies have reported cardiac impairment to varying degrees by varying methodologies. Using cardiac MR (CMR), we investigated a 12-month trajectory of abnormalities in Long COVID. Objectives To investigate cardiac abnormalities 1-year post-SARS- CoV-2 infection. Results Technical success of multiorgan and CMR assessment in non- acute settings was 99.1% and 99.6% at baseline, and 98.3% and 98.8% at follow- up. Of individuals with Long COVID, 102/534 (19%) had CMR abnormalities at baseline; 71/102 had complete paired data at 12 months. Of those, 58% presented with ongoing CMR abnormalities at 12 months. High sensitivity cardiac troponin I and B- type natriuretic peptide were not predictive of CMR findings, symptoms or clinical outcomes. At baseline, low LVEF was associated with persistent CMR abnormality, abnormal GLS associated with low quality of life and abnormal T1 in at least three segments was associated with better clinical outcomes at 12 months. Conclusion CMR abnormalities (left entricular or right ventricular dysfunction/dilatation and/ or abnormal T1mapping), occurred in one in five individuals with Long COVID at 6 months, persisting in over half of those at 12 months. Cardiac- related blood biomarkers could not identify CMR abnormalities in Long COVID.

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Population - With a Disability, 16 Years and over

Graph and download economic data for Not in Labor Force from Jan 1975 to Jun 2023 about labor force, 16 years +, labor, household survey, and USA.

Anfang April wurde erstmals die Möglichkeit eines SARS-CoV-2-assoziierten Guillain-Barré-Syndroms (GBS) in 'Lancet Neurology' diskutiert [1]. Kurz darauf folgten zwei weitere Publikationen aus Europa, die ein GBS bzw. eine GBS-Variante bei COVID-19-Patienten beschreiben [2, 3]. Das GBS entsteht häufig in Folge von Infektionen, z.B. nach bakterieller Darminfektion oder Infektion mit dem Zytomegalievirus.

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Thanks to Arlene Harris for great coverage in today's @BelTelGood grief, I wish Rosie and I didn't have to keep doing this. But until we have #CleanAirForAll, we will keep making #LongCovidKids. So we will keep going... pic.twitter.com/mwlWgJUyrP— Colin Pidgeon #CleanAirForAll #fblc (@baldypidge) July 11, 2023

Purpose: To evaluate using quantitative analysis on chest CT images a possible lung volume reduction in Long COVID patients who complain mild respiratory symptoms, with chest CT negative for inflammatory findings. Materials and Methods: CT images of patients from 18 to 40 years old who underwent chest CT scan at our institution were analyzed retrospectively, using AwServer Thoracic VCAR software for a quantitative study. Exclusion criteria were inflammatory findings at CT, previous lung surgery, lung cancer, and breath artifacts that invalidate the quality of images. Patients were divided into two groups: in the first one (“post-COVID”) were patients who had previous SARS-CoV-2 infection, confirmed by an RT-PCR, who underwent chest CT from 3 to 6 months after their negativization for long COVID symptoms; in the control group (“non-COVID”), were enrolled patients who underwent a chest CT scan from January 2018 to December 2019, before the spread of COVID in Italy. Results: Our final population included 154 TC, 77 post-COVID patients (mean age 33 ± 6) and 77 non-COVID patients (mean age 33 ± 4.9). Non statistical significative differences were obtained between groups in terms of age, sex, and other characteristics that affect total lung capacity such as obesity, thoracic malformations, and smoking habit. Mean values of the total lung volume (TV), right-lung volume (RV), and left-lung volume (LV) in the post-COVID group compared with non-COVID group were, respectively: 5.25 ± 0.25 L vs. 5.72 ± 0.26 L (p = 0.01); 2.76 ± 0.14 L vs. 3 ± 0.14 L (p = 0.01); 2.48 ± 0.12 L vs. 2.72 ± 0.12 L (p = 0.01). Conclusion: In patients with symptoms suggesting Long COVID and negative chest CT macroscopic findings, quantitative volume analysis demonstrated a mean value of reduction in lung volume of 10% compared to patients of the same age who never had COVID. A chest CT negative for inflammatory findings may induce clinicians to attribute Long COVID mild respiratory symptoms to anxiety, especially in young patients. Our study brings us beyond appearances and beyond the classic radiological signs, introducing a quantitative evaluation of lung volumes in these patients. It is hard to establish to what extent this finding may contribute to Long COVID symptoms, but this is another step to gain a wider knowledge of the potential long-term effects caused by this new virus.

An Incomplete and Growing Resource

Nature Communications - Rapid detection of respiratory pathogens circulating in indoor environments could facilitate improved infection prevention responses. In this proof-of-concept study, the...

Scientific Reports - Post COVID-19 symptoms are common, also among young adults in the general population

Eine COVID-19-Erkrankung während der Schwangerschaft verdoppelt das Risiko für eine Totgeburt. Ein internationales Forscherteam konnte nun aufklären,…

Nature Reviews Materials - Lipid nanoparticle–mRNA formulations have entered the clinic as coronavirus disease 2019 (COVID-19) vaccines, marking an important milestone for mRNA therapeutics....

The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.

Severe cases of COVID-19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show that SARS-CoV-2-infected cells express the Spike p …

To assess the incidence and risk of AMI in COVID-19 survivors after SARS-CoV-2 infection by a systematic review and meta-analysis of the available data. Methods Data were obtained searching MEDLINE and Scopus for all studies published at any time up to September 1, 2022 and reporting the risk of incident AMI in patients recovered from COVID-19 infection. AMI risk was evaluated using the Mantel–Haenszel random effects models with Hazard ratio (HR) as the effect measure with 95% confidence interval (CI) while heterogeneity was assessed using Higgins and Thomson I2 statistic. Results Among 2765 articles obtained by our search strategy, four studies fulfilled the inclusion criteria for a total of 20,875,843 patients (mean age 56.1 years, 59.1% males). Of them, 1,244,604 had COVID-19 infection. Over a mean follow-up of 8.5 months, among COVID-19 recovered patients AMI occurred in 3.5 cases per 1.000 individuals compared to 2.02 cases per 1.000 individuals in the control cohort, defined as those who did not experience COVID-19 infection in the same period). COVID-19 patients showed an increased risk of incident AMI (HR: 1.93, 95% CI: 1.65–2.26, p 0.0001, I2 = 83.5%). Meta-regression analysis demonstrated that the risk of AMI was directly associated with age (p = 0.01) and male gender (p = 0.001), while an indirect relationship was observed when the length of follow-up was utilized as moderator (p 0.001). Conclusion COVID-19 recovered patients had an increased risk of AMI.

Although the advantages of COVID-19 vaccination appear to outweigh the risks, pharmacovigilance must be maintained to monitor potentially fatal adverse events and identify possible associations.

»Von den 3,2 Millionen Kindern und Jugendlichen (0-17 Jahre) in England mit einer ersten COVID-Infektion in diesem Zeitraum wurden fast 30.000 ins Krankenhaus eingeliefert.«

A new study looks at all children hospitalised with a first recorded COVID infection in England from July 2020 to February 2022.

Objective To describe hospital admissions associated with SARS-CoV-2 infection in children and adolescents. Design Cohort study of 3.2 million first ascertained SARS-CoV-2 infections using electronic health care record data. Setting England, July 2020 to February 2022. Participants About 12 million children and adolescents (age

Cellular and Molecular Life Sciences - Under physiological conditions, hematopoietic stem and progenitor cells (HSPCs) in the bone marrow niches are responsible for the highly regulated and...

A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory s…

Background: The post-COVID-19 condition (PCC) is a disabling syndrome affecting 5-15% of subjects who survive COVID-19. SARS-CoV-2 mediated vagus nerve dysfunct

Long COVID symptoms, such as fatigue, difficulty breathing, and brain fog, may be a consequence of damage to the vagus nerve.