Covid19-Sources

Calgary – Kinder, die eine Infektion mit SARS-CoV-2 hatten, haben in den Folgemonaten häufiger gesundheitliche Beschwerden. Insbesondere klagen sie häufiger... #COVID19 #Studie #JAMA

Verdacht bestätigt: Das "Epizentrum" der Corona-Pandemie war tatsächlich der Fisch- und Tiermarkt von Wuhan, wie nun gleich zwei Studien belegen. Indizien

Wie immer nur stupide Impf-Propaganda!https://t.co/23Vf4MDkqmhttps://t.co/SCOXUG3aTShttps://t.co/GBFFAe03Z3https://t.co/e3jL4wJGU9https://t.co/zCdymEZb20https://t.co/WCKyJiGMRm— René (@Rhodan_77) July 24, 2022

Die durchschnittliche Lebenserwartung betrug im Jahr 2021 für neugeborene Mädchen 83,2 Jahre und für neugeborene Jungen 78,2 Jahre. Wie das Statistische Bundesamt (Destatis) weiter mitteilt, hat sich die Lebenserwartung von Neugeborenen im Vergleich zum letzten Vorpandemiejahr 2019 deutlich verringert: Bei Jungen um 0,6 Jahre, bei Mädchen um 0,4 Jahre. Hauptgrund für diese Entwicklung sind die außergewöhnlich hohen Sterbefallzahlen während der Coronawellen. Die Entwicklung der Lebenserwartung zeigt Veränderungen der Sterblichkeit an, die von der Altersstruktur unabhängig sind. Sie ist deshalb besonders gut für Zeitvergleiche geeignet.

Nature Genetics - Genetic and functional studies implicate allele-specific regulation of OAS1 splicing and nonsense-mediated decay in COVID-19 severity. The OAS1 risk haplotype is also associated...

The baseline composition of T cells directly impacts later response to pathogens, but the complexity of precursor states remains poorly defined. Here, we examined the baseline state of SARS-CoV-2-specific T cells in unexposed individuals. SARS-CoV-2-specific CD4+ T cells were identified in pre-pandemic blood samples by class II peptide-MHC tetramer staining and enrichment. Our data revealed a substantial number of SARS-CoV-2-specific T cells that expressed memory phenotype markers. Integrated phenotypic analyses demonstrated diverse pre-existing memory states that included cells with distinct polarization states and trafficking potential to barrier tissues. T cell clones generated from tetramer-labeled cells cross-reacted with antigens from commensal bacteria in the skin and gastrointestinal tract. Direct ex vivo tetramer staining for one spike-specific population showed a similar level of cross-reactivity to sequences from endemic coronavirus and commensal bacteria. These data highlight the complexity of precursor T cell repertoire and implicate non-infectious exposures to common microbes as a key factor that shapes human pre-existing immunity to SARS-CoV-2.

The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcomes with coronavirus disease 2019 (COVID-19) is that the immune response to the SARS-CoV-2 spike protein is enriched for antibodies directed against epitopes shared with endemic beta-coronaviruses and has a lower proportion of antibodies targeting the more protective variable regions of the spike. The magnitude of antibody responses to the SARS-CoV-2 full-length spike protein, its domains and subunits, and the SARS-CoV-2 nucleocapsid also correlated strongly with responses to the endemic beta-coronavirus spike proteins in individuals admitted to an intensive care unit (ICU) with fatal COVID-19 outcomes, but not in individuals with nonfatal outcomes. This correlation was found to be due to the antibody response directed at the S2 subunit of the SARS-CoV-2 spike protein, which has the highest degree of conservation between the beta-coronavirus spike proteins. Intriguingly, antibody responses to the less cross-reactive SARS-CoV-2 nucleocapsid were not significantly different in individuals who were admitted to an ICU with fatal and nonfatal outcomes, suggesting an antibody profile in individuals with fatal outcomes consistent with an “original antigenic sin” type response.

NEW: @UKHSA COVID-19 Variant Technical Briefing Technical Briefing: BA.4/5 + BA.2.75 https://t.co/hBtFci5YebShort thread 🧵 pic.twitter.com/9KwHzJUAJ6— 🇺🇦 Meaghan Kall (@kallmemeg) July 24, 2022

Urgent category-one surgery is having to be rescheduled at some Victorian hospitals amid crippling staff shortages, as doctors warn of a rise in people arriving at hospital with life-threatening complications after coronavirus and flu infections.

This retrospective cohort study examines the incidence of acute myocardial infarction and ischemic stroke after COVID-19 infection among vaccinated vs unvaccinated adults in Korea.

Herzinfarkt, Schlaganfall tritt in den Mo nach #COVID19 deutlich vermehrt auf. Diese Studie schaute sich Unterschied ≥2 #Impfungen vs ungeimpft an.➡️ 90% weniger kritischer Verlauf von COVID➡️ 1-6Mo nach Infektion 60% weniger Herz- und Hirninfarkte.https://t.co/nrb3PYgrmS— Wolfgang Hagen 💉🚴🏻‍♂️🇪🇺 (@docjosiahboone) July 23, 2022

Es mehren sich die Hinweise darauf, dass das Coronavirus eine Vielzahl ganz unterschiedlicher Hautsymptome hervorrufen kann. Neben frostbeulenartigen

Die Multisystemerkrankung COVID-19 manifestiert sich vorwiegend als Exanthem unterschiedlicher Morphologie, aber auch in Form von Pernionen-artigen Hautveränderungen, einer Livedo reticularis und akralen Ischämien. Die SARS-CoV-2-Infektion ist eine...

Die Zahlen des Berichtsjahres 2021 stehen wie schon das Vorjahr unter dem maßgeblichen Einfluss der COVID-19-Pandemie. In der nachfolgenden Übersicht sind die Auswirkungen dieser Sondersituation deutlich zu erkennen. Während die Unfallzahlen trotz Zunahmen weiterhin deutlich unter dem vorpandemischen Niveau bleiben, sind im Bereich der Berufskrankheiten erneut starke Fallzahlanstiege zu beobachten.

Berlin – Die höchsten Inzidenzen der hospitalisierten COVID-19-Fälle liegen in allen Altersgruppen in der ungeimpften Bevölkerung vor. Dies geht aus dem heute... #COVID19 #Impfen

Aktuell ist der Krankenstand in Deutschland bei einer Erkrankungsart so hoch wie nie. Woran liegt das?

The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against coronavirus disease 2019 (COVID-19). Our aim was to determine whether any MMR IgG titers are inversely correlated with severity in recovered COVID-19 patients previously vaccinated with MMR II. We divided 80 subjects into two groups, comparing MMR titers to recent COVID-19 severity levels. The MMR II group consisted of 50 subjects who would primarily have MMR antibodies from the MMR II vaccine, and a comparison group of 30 subjects consisted of those who would primarily have MMR antibodies from sources other than MMR II, including prior measles, mumps, and/or rubella illnesses. There was a significant inverse correlation (rs = −0.71, P  0.001) between mumps virus titers (mumps titers) and COVID-19 severity within the MMR II group. There were no significant correlations between mumps titers and severity in the comparison group, between mumps titers and age in the MMR II group, or between severity and measles or rubella titers in either group. Within the MMR II group, mumps titers of 134 to 300 arbitrary units (AU)/ml (n = 8) were found only in those who were functionally immune or asymptomatic; all with mild symptoms had mumps titers below 134 AU/ml (n = 17); all with moderate symptoms had mumps titers below 75 AU/ml (n = 11); all who had been hospitalized and had required oxygen had mumps titers below 32 AU/ml (n = 5). Our results demonstrate that there is a significant inverse correlation between mumps titers from MMR II and COVID-19 severity.

Correspondence from The New England Journal of Medicine — Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection

Emma Rezel-Potts and colleagues investigate whether the incidence of new diabetes mellitus and cardiovascular diseases are increased over 12 months after Covid-19 compared with matched controls.

A recent re-analysis of 2 randomised trials conducted before the pandemic found that a carrageenan-containing nasal spray shortened the duration of common colds caused by the OC43 or 229E coronaviruses. 🧵https://t.co/sYGl6qqUqu pic.twitter.com/76tdTFRZbo— Dr Zoë Hyde (@DrZoeHyde) July 15, 2022

Long Covid bedeutet für viele Menschen vor allem eines: ganz viele Fragezeichen. Zeit für einen Überblick.

We've had some interesting vaccine news in the last few days, and it's worth a closer look. A team from the NIAID, Emory, Moderna (and others) has reported results in a primate model for an Omicron-targeted mRNA booster shot that they've been working on, and the numbers are. . .a bit surprising. Macaque monkeys were dosed twice, four weeks apart, with the standard Moderna coronavirus vaccine, and then 41 weeks later one group of them got a booster of the same shot, while another got a booster of the new one with an Omicron variant sequence. Subsequent tests for neutralizing antibody levels, B-cell expansion, and response to a challenge with the Omicron virus itself showed that there was no difference between the two treatments at all.

There have been studies from Pfizer/BioNTech on Omicron neutralization in human plasma from different variant specific vaccines, and there these seem to help better against Omicron than the original.https://t.co/9si9MGMKTC— jorgenponder — om coronavirusepidemin (@jorgenponder) February 7, 2022

Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting antibody responses. Extraordinary progress has been made in understanding memory to SARS-CoV-2 infection and COVID-19 vaccines, addressing development; quantitative and qualitative features of different cellular and anatomical compartments; and durability of each cellular component and antibodies. Given the sophistication of the measurements; the size of the human studies; the use of longitudinal samples and cross-sectional studies; and head-to-head comparisons between infection and vaccines or between multiple vaccines, the understanding of immune memory for 1 year to SARS-CoV-2 infection and vaccines already supersedes that of any other acute infectious disease. This knowledge may help inform public policies regarding COVID-19 and COVID-19 vaccines, as well as the scientific development of future vaccines against SARS-CoV-2 and other diseases.

Our extensive scientific review of SARS-CoV-2 immune memory is published. Antibodies, CD4 T cells, CD8 T cells, memory B cells, and tissue resident cells. After vaccination, infection, or both, ready to battle COVID-19. Open access: https://t.co/28R4JHja4n @SetteLab pic.twitter.com/QIKzdeez2w— Prof. Shane Crotty (@profshanecrotty) July 15, 2022

Myocarditis and pericarditis are potential post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. We aimed to study the incidence of post-acute COVID-19 myocarditis and pericarditis. Retrospective cohort study of 196,992 adults after COVID-19 infection in Clalit Health Services members in Israel between March 2020 and January 2021. Inpatient myocarditis and pericarditis diagnoses were retrieved from day 10 after positive PCR. Follow-up was censored on 28 February 2021, with minimum observation of 18 days. The control cohort of 590,976 adults with at least one negative PCR and no positive PCR were age- and sex-matched. Since the Israeli vaccination program was initiated on 20 December 2020, the time-period matching of the control cohort was calculated backward from 15 December 2020. Nine post-COVID-19 patients developed myocarditis (0.0046%), and eleven patients were diagnosed with pericarditis (0.0056%). In the control cohort, 27 patients had myocarditis (0.0046%) and 52 had pericarditis (0.0088%). Age (adjusted hazard ratio [aHR] 0.96, 95% confidence interval [CI]; 0.93 to 1.00) and male sex (aHR 4.42; 95% CI, 1.64 to 11.96) were associated with myocarditis. Male sex (aHR 1.93; 95% CI 1.09 to 3.41) and peripheral vascular disease (aHR 4.20; 95% CI 1.50 to 11.72) were associated with pericarditis. Post COVID-19 infection was not associated with either myocarditis (aHR 1.08; 95% CI 0.45 to 2.56) or pericarditis (aHR 0.53; 95% CI 0.25 to 1.13). We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection.

The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (≥12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I2 statistics. The Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) reporting guideline was followed (registration PROSPERO CRD42021275408). The literature search yielded 8,373 publications, of which 21 studies met the inclusion criteria, and a total of 80,071 children and adolescents were included. The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. Limitations of the studies analyzed include lack of standardized definitions, recall, selection, misclassification, nonresponse and/or loss of follow-up, and a high level of heterogeneity. ### Competing Interest Statement SLL is an employee of Novartis Pharmaceutical Company; the statements presented in the paper do not necessarily represent the position of the company. The remaining authors have no competing interests to declare ### Funding Statement This work was supported by funds from Houston Methodist Research Institute, Houston, TX. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data relevant to the study are included in the article or uploaded as supplementary information. In addition, the datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request. * CI : Credible interval COVID-19 : Coronavirus disease 2019 CSS : cross-sectional study DM : diabetes mellitus QCed : Quality-Controlled IRR : Incidence Rate Ratios NICE : National Institute for Health and Care Excellence MIS-C : multisystem inflammatory syndrome ORs : Odds Ratios PCS : prospective cohort study PRISMA : Preferred Items for Systematic Reviews and Meta-Analyses RCS : retrospective cohort study rt-PCR : real-time reverse transcription-polymerase chain reaction SARS-CoV-2 : severe acute respiratory syndrome coronavirus 2 PASC : post-acute sequelae of SARS-CoV-2

CDC's home for COVID-19 data. Visualizations, graphs, and data in one easy-to-use website.

Even before the pandemic began, more people here were dying at younger ages than in comparably wealthy nations.