Covid19-Sources

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Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Impfungen sind extrem sicher. Trotzdem muss man festhalten: Es gibt kein Nullrisiko. Auch eine Impfung ist ein medizinischer Eingriff, und somit kann es wie nach jeder medizinischen Handlung zu Reaktionen kommen („keine Wirkung ohne Nebenwirkung“), dabei ist wichtig, dass das Verhältnis von Nutzen und Risiko aber immer zugunsten des Nutzens liegt. Das oberste Gebot der Medizin...
·reisemed.at·
Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.
·nature.com·
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)
·twitter.com·
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV
·twitter.com·
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
Doctors in Norway have been told to conduct more thorough evaluations of very frail elderly patients in line to receive the Pfizer BioNTec vaccine against covid-19, following the deaths of 23 patients shortly after receiving the vaccine. “It may be a coincidence, but we aren’t sure,” Steinar Madsen, medical director of the Norwegian Medicines Agency (NOMA), told The BMJ . “There is no certain connection between these deaths and the vaccine.” The agency has investigated 13 of the deaths so far and concluded that common adverse reactions of mRNA vaccines, such …
·bmj.com·
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9
·twitter.com·
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
Self-assembling protein nanoparticles in the design of vaccines
Self-assembling protein nanoparticles in the design of vaccines
For over 100 years, vaccines have been one of the most effective medical interventions for reducing infectious disease, and are estimated to save millions of lives globally each year. Nevertheless, many diseases are not yet preventable by vaccination. ...
·ncbi.nlm.nih.gov·
Self-assembling protein nanoparticles in the design of vaccines
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6
·twitter.com·
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms
·twitter.com·
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
Eine überstandene Covid-19 Erkrankung bedeutet nicht immer, auch restlos gesund zu sein. Wir möchten mit den Selbsthilfegruppen und allen Betroffenen sowie deren Angehörigen, einen Rahmen geben, in dem es möglich ist, auf Augenhöhe miteinander umzugehen. Im Austausch von gesammelten Erfahrungen, liegt für jeden Einzelnen ein großes Potential, seinen Weg besser zu finden.
·leben-mit-covid.de·
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that contribute to escape from the neutralizing antibody responses, and reducing vaccine protection from infection. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, and in unvaccinated convalescent COVID-19 patients (n = 70). We found that 70-80% of the CD4 and CD8 T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar to that of the Beta and Delta variants, despite Omicron harbouring considerably more mutations. Additionally, in Omicron-infected hospitalized patients (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those found in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). These results demonstrate that despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell response, induced by vaccination or natural infection, cross-recognises the variant. Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19, supporting early clinical observations from South Africa. ### Competing Interest Statement A. Sette is a consultant for Gritstone Bio, Flow Pharma, Arcturus Therapeutics, ImmunoScape, CellCarta, Avalia, Moderna, Fortress and Repertoire. All of the other authors declare no competing interests. LJI has filed for patent protection for various aspects of vaccine design and identification of specific epitopes. ### Funding Statement Research reported in this publication was supported by the South African Medical Research Council (SA-MRC) with funds received from the South African Department of Science and Innovation, including grants 96825, SHIPNCD 76756 and DST/CON 0250/2012. This work was also supported by the Poliomyelitis Research Foundation (21/65) and the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), which is supported by core funding from the Wellcome Trust (203135/Z/16/Z and 222574). This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N93021C00016 to A.S. and Contract No. 75N9301900065 to A.S, D.W. P.L.M. is supported by the South African Research Chairs Initiative of the Department of Science and Innovation and the National Research Foundation (NRF; Grant No 9834). W.A.B. and C.R. are supported by the EDCTP2 programme of the European Union's Horizon 2020 programme (TMA2017SF-1951-TB-SPEC to C.R. and TMA2016SF-1535-CaTCH-22 to W.A.B.). N.A.B.N acknowledges funding from the SA-MRC, MRC UK, NRF and the Lily and Ernst Hausmann Trust. A.S. acknowledges funding from the Bill and Melinda Gates award INV-018944, the NIH (AI138546) and the South African Medical Research Council. R.J.W. acknowledges funding from the Francis Crick Institute, which receives funding from Wellcome FC0010218, UKRI FC0010218 and CRUK FC0010218 and the Rosetrees Trust grant M926 (to C.R. and R.J.W.). For the purposes of open access, the authors have applied a CC-BY public copyright license to any author-accepted version arising from this submission. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study was approved by the University of Cape Town Human Research Ethics Committee (ref: HREC 190/2020 and 209/2020) and the University of the Witwatersrand Human Research Ethics Committee (Medical) (ref. M210429 and M210752), the Biomedical Research Ethics Committee at the University of KwaZulu-Natal (ref.BREC/00001275/2020) and the University of Pretoria Health Sciences Research Ethics Committee (ref. 247/2020). I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors
·medrxiv.org·
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
Brain imaging before and after COVID-19 in UK Biobank
Brain imaging before and after COVID-19 in UK Biobank
There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. The vast majority of brain imaging studies so far have focused on qualitative, gross pathology of moderate to severe cases, often carried out on hospitalised patients. It remains unknown however whether the impact of COVID-19 can be detected in milder cases, in a quantitative and automated manner, and whether this can reveal a possible mechanism for the spread of the disease. UK Biobank scanned over 40,000 participants before the start of the COVID-19 pandemic, making it possible to invite back in 2021 hundreds of previously-imaged participants for a second imaging visit. Here, we studied the effects of the disease in the brain using multimodal data from 782 participants from the UK Biobank COVID-19 re-imaging study, with 394 participants having tested positive for SARS- CoV-2 infection between their two scans. We used structural and functional brain scans from before and after infection, to compare longitudinal brain changes between these 394 COVID- 19 patients and 388 controls who were matched for age, sex, ethnicity and interval between scans. We identified significant effects of COVID-19 in the brain with a loss of grey matter in the left parahippocampal gyrus, the left lateral orbitofrontal cortex and the left insula. When looking over the entire cortical surface, these results extended to the anterior cingulate cortex, supramarginal gyrus and temporal pole. We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison, with, in addition, a greater loss of grey matter in the cingulate cortex, central nucleus of the amygdala and hippocampal cornu ammonis (all |Z|3). Our findings thus consistently relate to loss of grey matter in limbic cortical areas directly linked to the primary olfactory and gustatory system. Unlike in post hoc disease studies, the availability of pre- infection imaging data helps avoid the danger of pre-existing risk factors or clinical conditions being mis-interpreted as disease effects. Since a possible entry point of the virus to the central nervous system might be via the olfactory mucosa and the olfactory bulb, these brain imaging results might be the in vivo hallmark of the spread of the disease (or the virus itself) via olfactory and gustatory pathways. All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprintthis version posted June 15, 2021.;https://doi.org/10.1101/2021.06.11.21258690doi:medRxiv preprint
·medrxiv.org·
Brain imaging before and after COVID-19 in UK Biobank
Clinical Severity of COVID-19 Patients Admitted to Hospitals in Gauteng, South Africa During the Omicron-Dominant Fourth Wave by Waasila Jassat, Salim Abdool Karim, Caroline Mudara, Richard Welch, Lovelyn Ozougwu, Michelle Groome, Nevashan Govender, Anne von Gottberg, Nicole Wolter, DATCOV Author Group, Lucille Blumberg, Cheryl Cohen :: SSRN
Clinical Severity of COVID-19 Patients Admitted to Hospitals in Gauteng, South Africa During the Omicron-Dominant Fourth Wave by Waasila Jassat, Salim Abdool Karim, Caroline Mudara, Richard Welch, Lovelyn Ozougwu, Michelle Groome, Nevashan Govender, Anne von Gottberg, Nicole Wolter, DATCOV Author Group, Lucille Blumberg, Cheryl Cohen :: SSRN
Background: As Omicron became the dominant variant in South Africa, little is known about the severity of its clinical presentation. We describe the clinical se
·papers.ssrn.com·
Clinical Severity of COVID-19 Patients Admitted to Hospitals in Gauteng, South Africa During the Omicron-Dominant Fourth Wave by Waasila Jassat, Salim Abdool Karim, Caroline Mudara, Richard Welch, Lovelyn Ozougwu, Michelle Groome, Nevashan Govender, Anne von Gottberg, Nicole Wolter, DATCOV Author Group, Lucille Blumberg, Cheryl Cohen :: SSRN
(4) Johann Holzmann auf Twitter: "#ADE (Antibody Dependent Enhancement) oder #Infektionsverstärkende Antikörper. Ein Problem bei den #COVID19 #Impfstoffen? Was ist das? Wurde es überprüft bei der Entwicklung der Impfstoffe? Und gibt es Hinweise, dass ADE ein Problem sein könnte? Ein (langer) Thread 1/n" / Twitter
(4) Johann Holzmann auf Twitter: "#ADE (Antibody Dependent Enhancement) oder #Infektionsverstärkende Antikörper. Ein Problem bei den #COVID19 #Impfstoffen? Was ist das? Wurde es überprüft bei der Entwicklung der Impfstoffe? Und gibt es Hinweise, dass ADE ein Problem sein könnte? Ein (langer) Thread 1/n" / Twitter
#ADE (Antibody Dependent Enhancement) oder #Infektionsverstärkende Antikörper. Ein Problem bei den #COVID19 #Impfstoffen? Was ist das? Wurde es überprüft bei der Entwicklung der Impfstoffe? Und gibt es Hinweise, dass ADE ein Problem sein könnte? Ein (langer) Thread 1/n
·twitter.com·
(4) Johann Holzmann auf Twitter: "#ADE (Antibody Dependent Enhancement) oder #Infektionsverstärkende Antikörper. Ein Problem bei den #COVID19 #Impfstoffen? Was ist das? Wurde es überprüft bei der Entwicklung der Impfstoffe? Und gibt es Hinweise, dass ADE ein Problem sein könnte? Ein (langer) Thread 1/n" / Twitter
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection
Nature Medicine - A self-controlled case series using individual-patient-level data from over 38 million people aged 16 years and over, reveals an increased risk of myocarditis within a week of...
·nature.com·
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection
Under-reporting of adverse drug reactions : a systematic review - PubMed
Under-reporting of adverse drug reactions : a systematic review - PubMed
The purpose of this review was to estimate the extent of under-reporting of adverse drug reactions (ADRs) to spontaneous reporting systems and to investigate whether there are differences between different types of ADRs. A systematic literature search was carried out to identify studies providing a …
·pubmed.ncbi.nlm.nih.gov·
Under-reporting of adverse drug reactions : a systematic review - PubMed
Carrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re-analysis of randomized trial data - PubMed
Carrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re-analysis of randomized trial data - PubMed
In this individual patient data meta-analysis we examined datasets of two randomized placebo-controlled trials which investigated the effect of nasal carrageenan separately on children and adults. In both trials, iota-carrageenan was administered nasally three times per day for 7 days for patients w …
·pubmed.ncbi.nlm.nih.gov·
Carrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re-analysis of randomized trial data - PubMed
Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses
Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses
The furin cleavage site in SARS-CoV-2 is unique within the Severe acute respiratory syndrome–related coronavirus (SrC) species. We re-assessed diverse SrC from European horseshoe bats and reveal molecular determinants such as purine richness, RNA secondary structures and viral quasispecies potentially enabling furin cleavage. Furin cleavage thus likely emerged from the SrC bat reservoir via molecular mechanisms conserved across reservoir-bound RNA viruses, supporting a natural origin of SARS-CoV-2.
·biorxiv.org·
Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses
SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy
SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy
Our results show multisystemic histopathological alterations caused by SARS-CoV-2 infection and contribute to knowledge regarding the course of fatal COVID-19 in children. Furthermore, our findings of ChP infection and viral neurotropism suggest that SARS-CoV-2 may invade the central nervous system by blood-cerebrospinal fluid barrier disruption.
·thelancet.com·
SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy