The Omicron wave of covid was 10x more deadly for unvaccinated Americans — empowering anti-vaxxers like RFK is clearly a threat to American public health.
Endothelial Glycocalyx Anomalies and Ocular Manifestations in Patients with Post-Acute COVID-19
Objectives: To report ophthalmological and microvascular findings in patients with post-acute COVID-19. Methods: In this prospective, monocentric cohort study, we included patients with post-acute COVID-19 who presented with ophthalmological symptoms. All patients underwent indocyanine green angiography (ICGA), OCT, OCT-angiography, adaptive optics, and GlycoCheck assessments. Results: We included 44 patients, predominantly female (81.8%), with a mean age of 47.5 ± 11.5 years. Key ICGA findings revealed hyperreflective dots in 32 eyes (36.4%) and hemangioma-like lesions in 7 eyes (8.0%). Capillary non-perfusion in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was observed in 42 eyes (47.7%) and 21 eyes (23.9%), respectively. Eyes with hyperreflective dots exhibited a lower perfused boundary region (PBR), while those with superficial punctate keratitis showed a higher PBR (p = 0.02 and p = 0.002, respectively). Eyes with capillary non-perfusion in the SCP displayed lower capillary densities (CD4, CD5, and CD4-6; p = 0.001, 0.03, and 0.03, respectively), and eyes with non-perfusion in the DCP had lower CD4 (p = 0.03). A negative correlation was identified between capillary density and the wall-to-lumen ratio. Conclusions: Patients with post-acute COVID-19 demonstrate both retinal and choroidal vascular anomalies. Ocular pathology was associated with reduced capillary density. These injuries appear to stem more from microvascular disruptions than from persistent glycocalyx abnormalities.
Vascular fibrosis and extracellular matrix remodelling in post-COVID 19 conditions
Causal associations between viral infections and acute myocardial injury are not fully understood, with mechanisms potentially involving direct cardio…
Acute hepatitis of unknown aetiology in children: evidence for and against causal relationships with SARS-CoV-2, HAdv and AAV2
Background The cause of acute paediatric hepatitis of unknown aetiology (2022) has not been established despite extensive investigation.Objective To summarise the evidence for and against a causal role for human adenovirus (HAdv), adeno-associated virus 2 (AAV-2) and SARS-CoV-2 in outbreaks of paediatric hepatitis in 2022.Methods We appraised and summarised relevant evidence for each of the Bradford Hill criteria for causality using quantitative (statistical modelling) and qualitative (narrative coherence) approaches. Each team member scored the evidence base for each criterion separately for HAdv, AAV-2 and SARS-CoV-2; differences were resolved by discussion. We additionally examined criteria of strength and temporality by examining the lagged association between SARS-CoV-2 positivity, respiratory HAdv positivity, positive faecal HAdv specimens and excess A&E attendances in 1–4 years for liver conditions in England.Results Assessing criteria using the published literature and our modelling: for HAdv three Bradford Hill criteria (strength, consistency and temporality) were partially met; and five criteria (consistency, coherence, experimental manipulation, analogy and temporality) were minimally met. For AAV-2, the strength of association criterion was fully met, five criteria (consistency, temporality, specificity, biological gradient and plausibility) were partially met and three (coherence, analogy and experimental manipulation) were minimally met. For SARS-CoV-2, five criteria (strength of association, plausibility, temporality, coherence and analogy) were fully met; one (consistency) was partially met and three (specificity, biological gradient and experimental manipulation) were minimally met.Conclusion Based on the Bradford Hill criteria and modelling, HAdv alone is unlikely to be the cause of the recent increase in hepatitis in children. The causal link between SARS-CoV-2, and to a lesser degree AAV-2, appears substantially stronger but remains unproven. Hepatitis is a known complication of multisystem inflammatory syndrome in children following COVID-19, and SARS-CoV-2 has been linked to increased susceptibility to infection post-COVID-19, which may suggest complex causal pathways including a possible interaction with AAV-2 infection/reactivation in hosts that are genetically susceptible or sensitised to infection.
Pasteur Institut: Neurodegenerative Signatur von Long COVID im Hirnstamm
Neuropsychiatrische und kognitive Folgen nach -Infektion:
„Wir liefern schlüssige Beweise dafür, dass ein tatsächliches biologisches Problem ist, das auf die akute Infektion folgt.“🧵
— Ralf Wittenbrink (@RWittenbrink)
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying
mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists
in the skull-meninges-brain axis, inducing inflammation, neurodegeneration-related
changes, and increasing the brain’s vulnerability to further injury.
Die Vaers-Datenbank des CDC beweist nicht den Impftod eines Babys nach dem Stillen
Hunderte Nutzerinnen und Nutzer haben eine Behauptung auf Facebook geteilt, wonach die US-amerikanische Datenbank für Nebenwirkungen von Medikamenten (Vaers) den Todesfall eines Säuglings nach einer mRNA-Impfung der Mutter "verifiziert" haben soll. Die Datenbank führt allerdings nur Verdachtsfälle auf, die nicht geprüft sind. Expertinnen und Experten sind sich einig, dass mRNA aus Impfungen nicht in die Muttermilch und somit auch nicht ins Baby gelangen kann.
Identification of antiviral antihistamines for COVID-19 repurposing
There is an urgent need to identify therapies that prevent SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Although repurposed drug…
Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry - PubMed
The 2019 global coronavirus (COVID-19) pandemic has brought the world to a grinding halt, highlighting the urgent need for therapeutic and preventive solutions to slow the spread of emerging viruses. The objective of this study was to assess the anti-SARS-CoV-2 effectiveness of 8 FDA-approved cation …
Frontiers | Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is one of the most serious global health crises in r...
The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBio
In addition to human angiotensin-converting enzyme 2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can utilize alternative cofactors to facilitate viral entry. In this study, we discovered that histamine receptor H1 (HRH1) not only ...
Cardiorespiratory fitness response to endurance training in athletes post-COVID-19 compared to unaffected athletes
Background: Endurance sports primarily attract recreational athletes over 35 years, who impose an exceptionally rigorous and sustained demand on their cardiorespiratory systems. Objectives: This study aimed to determine the influence of COVID-19 on the cardiovascular, pulmonary, and skeletal muscle function of endurance athletes with exercise intolerance. Secondly, it aimed to compare the exercise response of endurance athletes post-COVID-19 to those unaffected using cardiopulmonary exercise test-related variables. Methods: This is a prospective observational cohort study of endurance athletes. An exposure group with protracted exercise tolerance underwent a resting lung function test and maximal cardiopulmonary exercise test. These were repeated after eight weeks of endurance training and compared to the published reference values and a control group of athletes unaffected by COVID-19. Results: The post-COVID-19 exposure group (n=57), mean age 44.5±8.1 years showed a poorer ventilatory threshold (p=0.004), and workload (p=0.05), with higher respiratory exchange ratio (p=0.05) than the control group (n=34), mean age 41.8±7.7 years. Maximal inspiratory pressure improved at follow-up in the COVID-19 group compared to the controls (p=0.03). Increased odds of pulmonary and skeletal muscle limitation to aerobic capacity were found in the COVID-19 group. The COVID-19 group responded positively to endurance training with improved VO2peak (p=0.005), maximal inspiratory pressure (p=0.04), oxygen-pulse (p=0.02), and maximal workload (p
Case Report of a 47-Year-Old Long COVID Patient Diagnosed With Alzheimer's Disease
A 47-year-old female patient was diagnosed with Alzheimer disease (AD) based on positive Amyloid-PET and Tau-PET imaging results, coupled with increased levels of plasma biomarkers (Aβ42/Aβ40, pTau181, and pTau217). In this report, we characterized this unusual AD case by integrating data from...
A 24-month study reveals that 7.2% of children consistently experience long-COVID symptoms, with tiredness, sleep issues, and headaches most commonly reported, highlighting the need for targeted interventions.
Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents
The impact of pre-infection vaccination on the risk of long COVID remains unclear in the pediatric population. We aim to assess the effectiveness of B…
Im Auftrag des BKK Dachverbands wurden im Juni 2024 insgesamt 3.060 sozialversicherungspflichtig Beschäftigte im Rahmen einer Online-Umfrage zu verschiedenen Aspekten ihrer Gesundheit und Arbeit befragt.
Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study
Long-term SARS-CoV-2 adverse health outcomes are of significant concern, especially among young adults with the potential for the greatest long-term m…
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection
Total-body PET imaging and microscopy analysis of rectosigmoid biopsies reveal prolonged T cell activation and SARS-CoV-2 RNA persistence following COVID-19.
Estimating the population-level effects of nonpharmaceutical interventions when transmission rates of COVID-19 vary by orders of magnitude from one contact to another
Long-term dysregulation of plasma peptidome in mild and multiple COVID-19 recovered patients revealed by a novel efficient peptidomics workflow
Analytical and Bioanalytical Chemistry - After recovering from COVID-19, many patients experience “long COVID” symptoms. Existing research has predominantly focused on moderate to...
The impact of vaccination status on post-acute sequelae in hospitalized COVID-19 survivors using a multi-disciplinary approach: An observational single center study
COVID-19 vaccines reduced mortality, hospitalizations and ICUs admissions. Conversely,
the impact of vaccination on Long COVID-19 syndrome is still unclear. This study compared
the prevalence of post-acute sequelae at short and long-term follow-up among hospitalized
unvaccinated and vaccinated COVID-19 survivors through a multidisciplinary approach.
Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways - Cell Communication and Signaling
The 2019 outbreak of SARS-CoV-2 has caused a major worldwide health crisis with high rates of morbidity and death. Interestingly, it has also been linked to cancer, which begs the issue of whether it plays a role in carcinogenesis. Recent studies have revealed various mechanisms by which SARS-CoV-2 can influence oncogenic pathways, potentially promoting cancer development. The virus encodes several proteins that alter key signaling pathways associated with cancer hallmarks. Unlike classical oncogenic viruses, which transform cells through viral oncogenes or by activating host oncogenes, SARS-CoV-2 appears to promote tumorigenesis by inhibiting tumor suppressor genes and pathways while activating survival, proliferation, and inflammation-associated signaling cascades. Bioinformatic analyses and experimental studies have identified numerous interactions between SARS-CoV-2 proteins and cellular components involved in cancer-related processes. This review explores the intricate relationship between SARS-CoV-2 infection and cancer, focusing on the regulation of key hallmarks driving initiation, promotion and progression of cancer by viral proteins. By elucidating the underlying mechanisms driving cellular transformation, the potential of SARS-CoV-2 as an oncovirus is highlighted. Comprehending these interplays is essential to enhance our understanding of COVID-19 and cancer biology and further formulating strategies to alleviate SARS-CoV-2 influence on cancer consequences. Graphical Abstract Schematic representation of SARS-CoV-2 associated alterations contributing to various hallmarks of cancer. PI3K/ AKT/mTOR: Phosphoinositide 3-kinase/Protein Kinase B/ Mammalian Target of Rapamycin; TGF-β, Transforming Growth Factor-beta; VEGF, Vascular Endothelial Growth Factor; JNK, Jun N-terminal Kinase; HDAC, Histone Deacetylase; DNMT, DNA Methyltransferase; HIF-1α: Hypoxia-Inducible Factor 1-alpha; pRB, Retinoblastoma Protein. This image was created using BioRender software.