Covid19-Sources

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread. The common methods to monitor and quantitate SARS-CoV-2 infectivity in cell culture are so far time-consuming and labor-intensive. Using the Sleeping Beauty transposase system, we generated a robust and versatile reporter cell system that allows SARS-CoV-2 infection experiments compatible for high-throughput and live cell imaging. The reporter cell is based on lung derived A549 cells, which show a profou...

Das Virus könnte schuld daran sein, wenn sich bei schweren Covid-19-Fällen der Zuckerstoffwechsel verschlechtert

Data on the clinical outcomes of children with COVID-19 are scarce, particularly in those with asymptomatic and mild disease.1 , 2 Studies involving adults suggest that long-term multisystem sequelae and complications can occur, even with mild COVID-19.3 We aimed to describe medium-term clinical outcomes 3–6 months after diagnosis in children with COVID-19 presenting to a tertiary paediatric hospital. We followed children (aged ≤18 years) at a dedicated COVID-19 follow-up clinic at the Royal Children's Hospital (RCH) in Melbourne, Australia, between March 21, 2020 and March 17, 2021. Children who tested positive for SARS-CoV-2 at the RCH or externally between March 21 and Oct 28, 2020, were referred to this clinic.

Correspondence from The New England Journal of Medicine — SARS-CoV-2 Infection after Vaccination in Health Care Workers in California

Adenoviruses are among the many pathogens and opportunistic agents that cause serious infection in the congenitally immunocompromised, in patients undergoing immunosuppressive treatment for organ and tissue transplants and for cancers, and in human immunodeficiency virus-infected patients. Adenoviru …

Behind the scenes from starter cells to a finished vaccine.

COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2’s entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in t...

Covid-19 testing programs that fail to support the prevention of onward transmission have minimal benefits at best, and are harmful at worst, say Neia Prata Menezes, Katherine Rucinski, and Stefan [...]More...

Objective To analyze the spectrum of neurological manifestations in children hospitalized with pandemic influenza A H1N1 virus of 2009 (pH1N1).Design Retrospective case series of children hospitalized from May 1, 2009, through November 30, 2009.Setting Tertiary-care children's...

Real-world data on antibody response post-vaccination in the general population are limited. 45,965 adults in the UK’s national COVID-19 Infection Survey receiving Pfizer-BioNTech or Oxford-AstraZeneca vaccines had 111,360 anti-spike IgG measurements. Without prior infection, seroconversion rates and quantitative antibody levels post single dose were lower in older individuals, especially >60y. Two doses achieved high responses across all ages, particularly increasing seroconversion in older people, to similar levels to those achieved after prior infection followed by a single dose. Antibod...

Results Anti-SARS-CoV-2 antibodies as well as neutralising activity could be detected in all study participants. IgG titres were significantly lower in patients as compared with controls (2053 binding antibody units (BAU)/mL ±1218 vs 2685±1102). Side effects were comparable in both groups. No severe adverse effects were observed, and no patients experienced a disease flare.Conclusion We show that SARS-CoV-2 mRNA vaccines lead to development of antibodies in immunosuppressed patients without considerable side effects or induction of disease flares. Despite the small size of this cohort, we were able to demonstrate the efficiency and safety of mRNA vaccines in our cohort.

Berlin – Unter den stark von SARS-CoV-2 betroffenen Menschen sind eher selten Kinder und Jugendliche. Aber auch sie können schwer erkranken oder sterben. Das...

Der Anteil derjenigen, die infolge einer Sars-CoV-2-Infektion sterben, liegt laut Virologe Christian Drosten bei rund einem Prozent. Damit geht seine Schätzung weg von der des RKI, das Institut meldete zuletzt 3,1 Prozent. Wie Drosten auf diese Schätzung kommt.

Objectives To assess the effectiveness of COVID-19 vaccination in preventing SARS-CoV-2 infection in the community. Design Prospective cohort study. Setting The UK population-representative longitudinal COVID-19 Infection Survey. Participants 373,402 participants aged ≥16 years contributing 1,610,562 RT-PCR results from nose and throat swabs between 1 December 2020 and 3 April 2021. Main outcome measures New RT-PCR-positive episodes for SARS-CoV-2 overall, by self-reported symptoms, by cycle threshold (Ct) value (

SARS-CoV-2 seroprevalence in the Middle EastIran (3 studies)https://t.co/2Y1kesOJythttps://t.co/99QOlO4srohttps://t.co/fwbk8PQRlCAfghanistanhttps://t.co/LBrsLd9SEFUAEFebruary 28, pages 17-19https://t.co/5WfiPfUsswIraqhttps://t.co/AjiQaKh4UQhttps://t.co/rKbOHcyhh1— Atomsk's Sanakan (@AtomsksSanakan) March 27, 2021

The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SA …

Background: Covid-19 has caused significant global mortality. Multiple vaccines have demonstrated efficacy in clinical trials though real-world effectiveness of vaccines against Covid-19 mortality in clinically and demographically diverse populations has not yet been reported. Methods: We used a retrospective cohort assembled from a cross-institution comprehensive data repository. Established patients of the health care system were categorized as not immunized, partially immunized, or fully immunized against SARS-CoV-2 with an mRNA vaccine through April 4, 2021. Outcomes were Covid-19 relat...

Atlanta/Georgia – In den ersten 11 Wochen der Impfkampagne gegen SARS-CoV-2 ist es in den USA zu keiner Häufung von Komplikationen bei Schwangeren gekommen.... #Studie #Schwangerschaft #Coronaimpfung

The acute clinical manifestations of COVID-19 are well characterized1,2; however, its post-acute sequalae have not been comprehensively described. Here, we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident sequalae including diagnoses, medication use, and laboratory abnormalities in 30-day survivors of COVID-19. We show that beyond the first 30 days of illness, people with COVID-19 exhibit higher risk of death and health resource utilization. Our high dimensional approach identifies incident sequala...

Einigen Long-Covid-Patienten geht es nach der Corona-Impfung besser. US-Forscher stellen jetzt eine spannende Hypothese auf. Möglicherweise liefern sie damit auch die Erklärung für die Ursache von Long Covid.