Covid19-Sources

Aim The aim of this study was to estimate the household transmissibility of SARS-CoV-2 for lineage B.1.1.7 compared with other lineages, by age and viral load. Further-more, we wanted to estimate whether there is a multiplicative or additive effect of the increased transmissibility of B.1.1.7 compared with other lineages. Background New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 has been estimated to be more transmissible than other previously known lineages, but the ass...

HERV-W ENV was highly expressed in the leukocytes of COVID-19 patients but not in those of healthy donors. Its expression correlated with the markers of T-cell differentiation and exhaustion and blood cytokine levels. The percentage of HERV-W ENV-positive lymphocytes correlated with inflammatory markers and pneumonia severity in COVID-19 patients. Notably, HERV-W ENV expression reflects the respiratory outcome of patients during hospitalization.

✈️ Outbreak—47 positive #COVID19 of a 188 seat Vistara flight from New Delhi to Hong Kong have tested positive, after all tested negative 72 hours prior. The scariest thing? Only 8 detected before they began quarantine. 39 were only identified later during hotel quarantine!🧵 pic.twitter.com/ws9Ig3xdWk— Eric Feigl-Ding (@DrEricDing) April 19, 2021

Das Virus vermehrt sich im Rachen – antiseptische Spülungen könnten helfen

#15,914 This weekend marks two weeks since my second COVID vaccination, and in the eyes of the CDC, I'm considered ` fully vaccinated ' an...

In Mecklenburg-Vorpommern werden vermehrt junge Menschen wegen Langzeiterkrankungen nach einer Covid-19-Infektion stationär aufgenommen. Das gab die Median Klinik in Heiligendamm bekannt.

Year 2020 will mark History, with the emergence of the new Covid-19 virus, and more importantly, the consequent political decisions to apply freedom restriction at such a large-scale. Identifying the human behaviours during this extraordinary period represents a unique opportunity to both improve our fundamental knowledge and to improve future management of similar issues. Throughout almost all the duration of the French lockdown (from March 24, 2020 to May 10, 2020), we carried out an online survey on more than 12,000 individuals well distributed over the country. This online survey was pe...

One in four global COVID-19 deaths is reported from Brazil with a health care system on the verge of collapse

Pennsylvania and the city of Los Angeles each moved up the dates when all adult residents will qualify for a shot. All 50 states should reach that point by next Monday.

Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in implementation of public health measures worldwide to mitigate disease spread, including; travel restrictions, lockdowns, messaging on handwashing, use of face coverings and physical distancing. As the pandemic progresses, exceptional decreases in seasonal respiratory viruses are increasingly reported. We aimed to evaluate the impact of the pandemic on circulation of influenza, respiratory syncytial virus and other seasonal respiratory viruses in Canada. Methods Epidemiologic data were obtained from the Cana...

This JAMA Insights review summarizes basic measures of indoor air ventilation as a means to explain how increases in frequency of air exchange and filtration capture efficiency could mitigate far-field airborne transmission of SARS-CoV-2 inside rooms and buildings.

Airborne transmission arises through the inhalation of aerosol droplets exhaled by an infected person and is now thought to be the primary transmission route of COVID-19. By assuming that the respiratory droplets are mixed uniformly through an indoor space, we derive a simple safety guideline for mitigating airborne transmission that would impose an upper bound on the product of the number of occupants and their time spent in a room. Our theoretical model quantifies the extent to which transmission risk is reduced in large rooms with high air exchange rates, increased for more vigorous resp...

The concerns stem from a phenomenon that is known as imprinting, which is believed to affect how we respond to some pathogens.

Die Coronakrise belastet alle, auch psychisch. Doch was macht sie mit wem? Kinder sind in besonderem Maße betroffen - manchmal aber auch in besonderem Maße resilient.

That the circulation of the new, potentially more infectious variants is responsible for the spike in cases after January 2021 seems increasingly inescapable.

Hint: It’s not a “lost year.” Also, the screen time with friends? It’s good for their mental health.

Die Gesundheitsämter wurden bislang wenig in die Beratung der Politik zur strategischen Planung von COVID-19-Maßnahmen einbezogen. Dabei spielen sie gerade in der Organisation der COVID-19-Bekämpfung, insbesondere in der Interaktion mit der...

Emerging evidence exists of increased transmissibility of B.1.1.7, and we found increased virus load by proxy for B.1.1.7 in our data. We did not identify an association of the variant with severe disease in this hospitalised cohort.

IMPORTANCE Higher secondary attack rates related to variant of concern (VOC) index cases have been reported, but have not been explored within households, which continue to be an important source of coronavirus disease 2019 (COVID-19) transmission OBJECTIVE To compare secondary attack rates in households with VOC versus non-VOC index cases. DESIGN A retrospective cohort study of household index cases reported from February 7 – 27, 2021. A propensity-score matched cohort was derived to calculate adjusted estimates. SETTING Ontario, Canada. PARTICIPANTS A population-based cohort of all privat...

Brazil's hospitals were running out of drugs needed to sedate COVID-19 patients on Thursday, with the government urgently seeking to import supplies amid reports of the seriously ill being tied down and intubated without effective sedatives.

Background Narratives about complaints in children and adolescents caused by wearing a mask are accumulating. There is, to date, no registry for side effects of masks. Methods In the context of the www.co-ki.de multi-study complex, an online registry has been set up where parents, doctors, pedagogues and others can enter their observations. On 20 October 2020, 363 doctors were asked to make entries and to make parents and teachers aware of the registry. Results By 26 October 2020, a total of 20,353 people had taken part in the survey. The group of parents alone entered data on a total of 25...

Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: “The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne transmission”.1 This conclusion, and the wide circulation of the review's findings, is concerning because of the public health implications.

COVID-19 leads to a several-times higher risk of cerebral venous thrombosis (CVT) blood clots than current COVID-19 vaccines.

Alles über Normalwert und Sauerstoffsättigung (O2S), über die Bestimmung im Labor, sowie Ursachen von erhöhten und niedrigen Werten im Blut.

1Title page Article type: Short communication Names of the authors: Ralph Brinks (1,2), Helmut Küchenhoff (1), Jörg Timm (3), Tobias Kurth (4), Annika Hoyer (1) Title: Epidemiological measures for informing the general public during the SARS-CoV-2-outbreak: simulation study about bias by incomplete case-detection Affiliations of the authors: (1) Department of Statistics, Ludwig-Maximilians-Universität Munich, Munich, Germany (2) Medical Faculty, Department and Hiller Research Unit for Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany (3) Medical Faculty, Institute of Virology, University Hospital Düsseldorf, Düsseldorf, Germany (4) Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany Corresponding author: Ralph Brinks, E-Mail: Ralph.Brinks@stat.uni-muenchen.de Abstract During the SARS-CoV-2 outbreak, several epidemiological measures, such as cumulative case-counts, incidence rates, effective reproduction numbers and doubling times, have been used to inform the general public and to justify interventions such as lockdown. During the course of the epidemic, it has been very likely that not all infectious people have been identified, which lead to incomplete case-detection. Apart from asymptomatic infections, possible reasons for incomplete case-detection are availability of test kits and changes in test policies during the course of the epidemic. So far, it has not been examined how biased the reported epidemiological measures are in the presence of incomplete case detection. In this work, we assess the four frequently used measures with respect to incomplete case-detection: 1) cumulative case-count, 2) incidence rate, 3) effective reproduction number and 4) doubling time. We apply an age-structured SIR model to simulate a SARS-CoV-2 outbreak followed by a lockdown in a hypothetical population. Different scenarios about temporal variations in case-detection are applied to the four measures during outbreak and lockdown.

Dieser Artikel hätte meines Erachtens auf die Titelseite der Sonntagszeitung gehört. Hervorragend. pic.twitter.com/weOQeP4y24— Sus Scrofa - ZeroCovid saves lives and livelihoods (@SusScro58355800) April 11, 2021

The most important vaccine in Latin America—SinoVac’s CoronaVac reports new trial results from Brazil 🇧🇷—Efficacy against symptomatic #COVID19–50.7%. Moderate & severe: 83.7% / 100%. Delayed 2nd dose no issue. Neut. titres lower in age>=60 against #P1.🧵https://t.co/tMg6Kn8TAe pic.twitter.com/XtHo9gnAzO— Eric Feigl-Ding (@DrEricDing) April 12, 2021

Emergence of novel variants of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vaccination of macaques using a two-dose regimen resulted in robust, predominantly Th1 CD4+ T cell responses and reciprocal peak mean neutralizing antibody titers of 14,000-21,000. Rapid control of viral r...