Adenoviruses in the immunocompromised host - PubMed
Adenoviruses are among the many pathogens and opportunistic agents that cause serious infection in the congenitally immunocompromised, in patients undergoing immunosuppressive treatment for organ and tissue transplants and for cancers, and in human immunodeficiency virus-infected patients. Adenoviru …
Emergence of SARS-CoV-2 through recombination and strong purifying selection | Science Advances
COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2’s entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in t...
Covid-19 testing programs: who benefits? - The BMJ
Covid-19 testing programs that fail to support the prevention of onward transmission have minimal benefits at best, and are harmful at worst, say Neia Prata Menezes, Katherine Rucinski, and Stefan [...]More...
Pediatric Neurological Complications of 2009 Pandemic Influenza A (H1N1) | Infectious Diseases | JAMA Neurology | JAMA Network
Objective To analyze the spectrum of neurological manifestations in children hospitalized with pandemic influenza A H1N1 virus of 2009 (pH1N1).Design Retrospective case series of children hospitalized from May 1, 2009, through November 30, 2009.Setting Tertiary-care children's...
The impact of SARS-CoV-2 vaccines on antibody responses in the general population in the United Kingdom | medRxiv
Real-world data on antibody response post-vaccination in the general population are limited. 45,965 adults in the UK’s national COVID-19 Infection Survey receiving Pfizer-BioNTech or Oxford-AstraZeneca vaccines had 111,360 anti-spike IgG measurements. Without prior infection, seroconversion rates and quantitative antibody levels post single dose were lower in older individuals, especially >60y. Two doses achieved high responses across all ages, particularly increasing seroconversion in older people, to similar levels to those achieved after prior infection followed by a single dose. Antibod...
Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort - annrheumdis-2021-220272.full.pdf
Results Anti-SARS-CoV-2 antibodies as well as neutralising activity could be detected in all study participants. IgG titres were significantly lower in patients as compared with controls (2053 binding antibody units (BAU)/mL ±1218 vs 2685±1102). Side effects were comparable in both groups. No severe adverse effects were observed, and no patients experienced a disease flare.Conclusion We show that SARS-CoV-2 mRNA vaccines lead to development of antibodies in immunosuppressed patients without considerable side effects or induction of disease flares. Despite the small size of this cohort, we were able to demonstrate the efficiency and safety of mRNA vaccines in our cohort.
Elf Todesfälle durch COVID-19 bei Kindern und Jugendlichen
Berlin – Unter den stark von SARS-CoV-2 betroffenen Menschen sind eher selten Kinder und Jugendliche. Aber auch sie können schwer erkranken oder sterben. Das...
Christian Drosten nennt Sterblichkeitsrate - die liegt weit weg vom RKI-Wert - FOCUS Online
Der Anteil derjenigen, die infolge einer Sars-CoV-2-Infektion sterben, liegt laut Virologe Christian Drosten bei rund einem Prozent. Damit geht seine Schätzung weg von der des RKI, das Institut meldete zuletzt 3,1 Prozent. Wie Drosten auf diese Schätzung kommt.
Impact of vaccination on SARS-CoV-2 cases in the community: a population-based study using the UK’s COVID-19 Infection Survey | medRxiv
Objectives To assess the effectiveness of COVID-19 vaccination in preventing SARS-CoV-2 infection in the community. Design Prospective cohort study. Setting The UK population-representative longitudinal COVID-19 Infection Survey. Participants 373,402 participants aged ≥16 years contributing 1,610,562 RT-PCR results from nose and throat swabs between 1 December 2020 and 3 April 2021. Main outcome measures New RT-PCR-positive episodes for SARS-CoV-2 overall, by self-reported symptoms, by cycle threshold (Ct) value (
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SA …
Real World Effectiveness of COVID-19 mRNA Vaccines against Hospitalizations and Deaths in the United States | medRxiv
Background: Covid-19 has caused significant global mortality. Multiple vaccines have demonstrated efficacy in clinical trials though real-world effectiveness of vaccines against Covid-19 mortality in clinically and demographically diverse populations has not yet been reported. Methods: We used a retrospective cohort assembled from a cross-institution comprehensive data repository. Established patients of the health care system were categorized as not immunized, partially immunized, or fully immunized against SARS-CoV-2 with an mRNA vaccine through April 4, 2021. Outcomes were Covid-19 relat...
SARS-CoV-2: Bisher keine Hinweise auf erhöhtes Impfrisiko für...
Atlanta/Georgia – In den ersten 11 Wochen der Impfkampagne gegen SARS-CoV-2 ist es in den USA zu keiner Häufung von Komplikationen bei Schwangeren gekommen.... #Studie #Schwangerschaft #Coronaimpfung
High-dimensional characterization of post-acute sequalae of COVID-19 | Nature
The acute clinical manifestations of COVID-19 are well characterized1,2; however, its post-acute sequalae have not been comprehensively described. Here, we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident sequalae including diagnoses, medication use, and laboratory abnormalities in 30-day survivors of COVID-19. We show that beyond the first 30 days of illness, people with COVID-19 exhibit higher risk of death and health resource utilization. Our high dimensional approach identifies incident sequala...
Einigen Long-Covid-Patienten geht es nach der Corona-Impfung besser. US-Forscher stellen jetzt eine spannende Hypothese auf. Möglicherweise liefern sie damit auch die Erklärung für die Ursache von Long Covid.
Increased Transmissibility of SARS-CoV-2 Lineage B.1.1.7 by Age and Viral Load: Evidence from Danish Households | medRxiv
Aim The aim of this study was to estimate the household transmissibility of SARS-CoV-2 for lineage B.1.1.7 compared with other lineages, by age and viral load. Further-more, we wanted to estimate whether there is a multiplicative or additive effect of the increased transmissibility of B.1.1.7 compared with other lineages. Background New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 has been estimated to be more transmissible than other previously known lineages, but the ass...
HERV-W ENV was highly expressed in the leukocytes of COVID-19 patients but not in those of healthy donors. Its expression correlated with the markers of T-cell differentiation and exhaustion and blood cytokine levels. The percentage of HERV-W ENV-positive lymphocytes correlated with inflammatory markers and pneumonia severity in COVID-19 patients. Notably, HERV-W ENV expression reflects the respiratory outcome of patients during hospitalization.
(4) Eric Feigl-Ding auf Twitter: "✈️ Outbreak—47 positive #COVID19 of a 188 seat Vistara flight from New Delhi to Hong Kong have tested positive, after all tested negative 72 hours prior. The scariest thing? Only 8 detected before they began quarantine. 39 were only identified later during hotel quarantine!🧵 https://t.co/ws9Ig3xdWk" / Twitter
✈️ Outbreak—47 positive #COVID19 of a 188 seat Vistara flight from New Delhi to Hong Kong have tested positive, after all tested negative 72 hours prior. The scariest thing? Only 8 detected before they began quarantine. 39 were only identified later during hotel quarantine!🧵 pic.twitter.com/ws9Ig3xdWk— Eric Feigl-Ding (@DrEricDing) April 19, 2021
