Covid19-Sources

Objective Most SARS‐CoV‐2‐infected individuals never require hospitalization. However, some develop prolonged symptoms. We sought to characterize the spectrum of neurologic manifestations in non‐hos...

Góð ráð, traustar upplýsingar og nýjustu fréttir af COVID-19 og aðgerðum við að hefta útbreiðslu.

Nach dem ja die Impfkampagne schon 2 Monate läuft ist es Zeit die Terminprognosen auf eine unterschiedliche Art zu meinem ursprünglichen…

The SARS-CoV-2 lineage B.1.1.7, now designated Variant of Concern 202012/01 (VOC) by Public Health England, originated in the UK in late Summer to early Autumn 2020. We examine epidemiological evidence for this VOC having a transmission advantage from several perspectives. First, whole genome sequence data collected from community-based diagnostic testing provides an indication of changing prevalence of different genetic variants through time. Phylodynamic modelling additionally indicates that genetic diversity of this lineage has changed in a manner consistent with exponential growth. Seco...

Structured Abstract Objectives: The long-term consequences of severe Covid-19 requiring hospital admission are not well characterised. The objective of this study was to establish the long-term effects of Covid-19 following hospitalisation and the impact these may have on patient reported outcome measures. Design: A multicentre, prospective cohort study with at least 3 months follow-up of participants admitted to hospital between 5th February 2020 and 5th October 2020. Setting: 31 hospitals in the United Kingdom. Participants: 327 hospitalised participants discharged alive from hospital wit...

Simulation der Intensivbettenauslastung für COVID-19 in Abhängigkeit von der Infektionsdynamik und dem zu erwartenden Impfeffekt

GOV.UK Coronavirus dashboard

Countdown zum Lockdown: 4 Szenarien für die nächsten 4 Wochen

Änderung pro Woche der 7-Tage-Inzidenze für alle Altersgruppen von Deutschland für Meldewochen 2021-KW09 in Bezug auf 2021-KW06 und 2021-KW10 in Bezug auf 2021-KW09. Die Änderung bei KW09 vs. KW06 ist auf eine Woche normiert.

Background: The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and adverse pregnancy outcomes. Methods: We conducted a systematic review and meta-analysis of observational studies with comparison data on SARS-CoV-2 infection and severity of COVID-19 during pregnancy. We searched for eligible studies in MEDLINE, Embase, ClinicalTrials.gov, medRxiv and Cochrane databases up to Jan. 29, 2021, using Medical Subject Heading...

Montreal – Eine Infektion mit SARS-CoV-2 in der Schwangerschaft kann eine Präeklampsie auslösen mit den bekannten Gefahren für die Gesundheit von Mutter und... #COVID-19 #Schwangerschaft

SARS-CoV-2 may cause acute respiratory disease, but the infection can also initiate neurological symptoms. Here we show that SARS-CoV-2 infection causes brain inflammation in the macaque model. An increased metabolic activity in the pituitary gland of two macaques was observed by longitudinal positron emission tomography-computed tomography (PET-CT). Post-mortem analysis demonstrated infiltration of T-cells and activated microglia in the brain, and viral RNA was detected in brain tissues from one animal. We observed Lewy bodies in brains of all rhesus macaques. These data emphasize the viru...

The case detection ratio of COVID-19 infections varies over time due to changing testing capacities, modified testing strategies and also, apparently, due to the dynamics in the number of infected itself. In this paper we investigate these dynamics by jointly looking at the reported number of detected COVID-19 infections with non-fatal and fatal outcomes in different age groups in Germany. We propose a statistical approach that allows us to spotlight the case detection ratio and quantify its changes over time. With this we can adjust the case counts reported at different time points so that...

Coexposure to airborne pollen enhances susceptibility to respiratory viral infections, regardless of the allergy status. We hypothesized this could be also true for SARS-CoV-2 infections. To investigate this, we tested for relationships between SARS-CoV-2 infection rates and pollen concentrations, along with humidity, temperature, population density, and lockdown effects. Our unique dataset derives from 130 sites in 31 countries and across five continents. We found that pollen, sometimes in synergy with humidity and temperature, explained, on average, 44% of the infection rate variability. ...

As is often pointed out by prolockdown publications like the New York Times, Sweden has experienced covid-19 deaths at a rate above that of some of its neighbors that imposed relatively strict

Since the onset of the COVID-19 pandemic, paediatricians and child mental health practitioners have noticed an increase in tic symptoms in some children and adolescents already diagnosed with tic disorders.1 Interestingly, clinicians have also seen a marked increase in presentations of sudden and new onset of severe tics and ‘tic-like’ attacks. There is an urgent need to collate systematic data on this group as this is a rare and unusual subtype of tics and Tourette syndrome, differing in age and type of onset and expected patterns of tics. Typically, childhood tics start around 5–7 years a...

Recombinant SARS-CoV-2 genomes involving lineage B.1.1.7 in the UK Ben Jackson1, Andrew Rambaut1, Oliver G Pybus2, David L Robertson3, Tom Connor4, Nicholas J Loman5, The COVID-19 Genomics UK (COG-UK) consortium6 1 University of Edinburgh 2 University of Oxford 3 MRC-University of Glasgow Centre for Virus Research 4 Cardiff University 5 University of Birmingham 6 https://www.cogconsortium.uk – full consortium authorship list is available here (492.7 KB) This work is licensed under a Cre...

Jeden Dienstag werden im Situationsbericht die altersspezifischen Anteile als 7-Tage-Inzidenz pro 100.000 Einwohner nach Meldewoche dargestellt. Auf den folgenden Tabellenblättern finden sich die altersspezifischen Fallzahlen sowie die altersspezifischen 7-Tage-Inzidenzen. Für die Berechnung von Inzidenzen wurde die Bevölkerungsstatistik mit Stand 31.12.2019 herangezogen.

Numerous viruses can cause upper respiratory tract infections. They often precede serious lower respiratory tract infections. Each virus has a seasonal pattern, with peaks in activity in different seasons. We examined the effects of daily local meteorological data (temperature, relative humidity, “humidity-range” and dew point) from Edinburgh, Scotland on the seasonal variations in viral transmission. We identified the seasonality of rhinovirus, adenovirus, influenza A and B viruses, human parainfluenza viruses 1–3 (HPIV), respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) f...

Even with vaccination efforts in full force, the theoretical threshold for vanquishing COVID-19 looks to be out of reach.

Background Annexin A2 is a phospholipid-binding protein involved in fibrinolysis, cell membrane stabilization and repair, and ensuring the integrity of the pulmonary microvasculature. Given the autoantibodies observed in COVID-19 and that Annexin A2 is a known target of antiphospholipid antibodies, we studied autoimmunity directed against Annexin A2 among hospitalized COVID-19 patients. Methods We used ELISA to identify the levels of IgG autoantibodies recognizing Annexin A2 and A5 among 86 hospitalized cases of COVID-19. Using logistic regression, we analyzed the association between anti-A...