Covid19-Sources

In November, a scientific paper estimated millions of years of life could be lost due to prolonged school closures in the U.S. The paper has since been corrected and critiqued.

Now the SARS-CoV-2 variants that were first identified in the UK (B.1.1.7), South Africa (B.1.351), and Brazil (P.1) have been found in the US, a couple of thoughts (i.e., speculation...) on what happens next, as I been getting many questions about transmission and immunity. 🧵👇 pic.twitter.com/2VZzGx19li— Kristian G. Andersen (@K_G_Andersen) January 31, 2021

Wuhan was the first epicentre of COVID-19 in the world, accounting for 80% of cases in China during the first wave. We aimed to assess household trans…

Objective to determine the statistical relationship between reported deaths and infections in the UK coronavirus outbreak Design Publicly available UK government data is used to determine a relationship between reported cases and deaths, taking into account various UK regions, age profiles and prevalence of the variant of concern (VOC) B.1.1.7. Main Outcome Measures Establishing a simple statistical relationship between detected cases and subsequent mortality. Results Throughout October and November 2020, deaths in England are well described as 1/55th of detected cases from 12 days previous...

This decision analytical model assesses the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissions in the community that likely occur from persons without symptoms.

Objectives The comparatively large proportion of asymptomatic SARS-CoV-2 infections in the youngest children opens up the possibility that kindergartens represent reservoirs of infection. However, actual surveys in kindergartens beyond individual outbreaks are rare. At the beginning of the second pandemic wave in Berlin, Germany, i.e., end of September 2020, we screened SARS-CoV-2 infections among kindergarten children, staff and connected household members. Methods Twelve kindergartens were randomly selected in the Berlin metropolitan area, and a total of 720 participants were recruited (1...

An intense debate on school closures to control the COVID-19 pandemic is ongoing in Europe. We prospectively examined transmission of SARS-CoV-2 from confirmed paediatric cases in Norwegian primary schools between August and November 2020. All in-school contacts were systematically tested twice during their quarantine period. With preventive measures implemented in schools, we found minimal child-to-child (0.9%, 2/234) and child-to-adult (1.7%, 1/58) transmission, supporting that under 14 year olds are not the drivers of SARS-CoV-2 transmission.

In Zeiten, in denen #Schulen i.d. Öffentlichkeit weitgehend zu einem Ort kindlicher+jugendlicher Glückseligkeit verklärt werden, möchte ich mit diesem Thread 🔽 daran erinnern, dass diese Vorstellung als "umstritten" gelten kann, gelinde gesagt. 1/15https://t.co/KtVIXM7GMT pic.twitter.com/34kJFqnJmm— Andrej Reisin (@Andrejnalin77) January 30, 2021

Statistical analysis of the daily diagnosis keys of the official German COVID-19 tracing app

Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying ant...

Original Article from The New England Journal of Medicine — Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

1/ Now for the thornier data.— Shane Crotty (@profshanecrotty) January 30, 2021

Can we do more as individuals to help slow the spread of coronavirus? We ask the experts

Als die Schweinegrippe sich 2009 verbreitete, war die Angst groß. Letztlich verlief die Pandemie glimpflicher als befürchtet. Der Virologe Christian Drosten erklärt, was damals passierte.

#COVID19 Skeptiker: Warum ist Grippe eliminiert? Schien mir wg kleinerem R0 der Grippe plausibel, habe deswegen aber Windpocken, Keuchhusten und Mumps in DE für die letzten 3J angeschaut. Sind gedrückt aber nicht weg. Evtl guter Anzeiger für Strenge und Befolgung der Massnahmen! pic.twitter.com/IdPUcrGZ0P— Carl Jakobs (@JakobsCarl) December 23, 2020

A Harvard researcher added up the number of years that Americans who died from Covid-19 might have lived had they reached a typical life expectancy.

Sie fragen, wir antworten: Zusammen mit der Berliner Zeitung und der Westdeutschen Zeitung beantworten wir die drängendsten offenen Punkte zu …

Perspective from The New England Journal of Medicine — The Climate Crisis and Covid-19 — A Major Threat to the Pandemic Response

How does mortality differ across countries? Examining the number of deaths per confirmed case and per 100,000 population. A global comparison.

The protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccine expressing the SARS-CoV-2 spike protein in non-human primates is demonstrated.

Große Unklarheiten: Nicht jeder, der sich mit dem Coronavirus SARS-CoV-2 infiziert, erkrankt an Covid-19 – so viel scheint klar. Doch wie hoch der Anteil

A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.

Governments are attempting to control the COVID-19 pandemic with nonpharmaceutical interventions (NPIs). However, the effectiveness of different NPIs at reducing transmission is poorly understood. We gathered chronological data on the implementation of NPIs for several European, and other, countries between January and the end of May 2020. We estimate the effectiveness of NPIs, ranging from limiting gathering sizes, business closures, and closure of educational institutions to stay-at-home orders. To do so, we used a Bayesian hierarchical model that links NPI implementation dates to nationa...

Analysing over 50,000 government interventions in more than 200 countries, Haug et al. find that combinations of softer measures, such as risk communication or those increasing healthcare capacity, can be almost as effective as disruptive lockdowns.

While large scale mobility data has become a popular tool to monitor the mobility patterns during the COVID-19 pandemic, the impacts of non-compulsory measures in Tokyo, Japan on human mobility patterns has been under-studied. Here, we analyze the temporal changes in human mobility behavior, social contact rates, and their correlations with the transmissibility of COVID-19, using mobility data collected from more than 200K anonymized mobile phone users in Tokyo. The analysis concludes that by April 15th (1 week into state of emergency), human mobility behavior decreased by around 50%, resul...