Covid19-Sources

From infectious diseases to brain activity, complex systems can be approximated using autoregressive models. Here, the authors show that incomplete sampling can bias estimates of the stability of such systems, and introduce a novel, unbiased metric for use in such situations.

From February to April 2020, many countries introduced variations on social distancing measures to slow the ravages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Publicly available data show that Germany has been particularly successful in minimizing death rates. Dehning et al. quantified three governmental interventions introduced to control the outbreak. The authors predicted that the third governmental intervention—a strict contact ban since 22 March—switched incidence from growth to decay. They emphasize that relaxation of controls must be done carefully, not only bec...

Test, trace, and isolate programmes are central to COVID-19 control. Here, Viola Priesemann and colleagues evaluate how to allocate scarce resources to keep numbers low, and find that if case numbers exceed test, trace and isolate capacity, there will be a self-accelerating spread.

Die Erhebung der Daten zur COVID-19-Impfung erfolgt in den Impfzentren und durch die Mobilen Impfteams. Autorisiertes Personal der Impfzentren und Impfteams können über die Webanwendung "Digitales Impfquotenmonitoring" die Daten eingeben und über eine gesicherte Internetverbindung täglich an die Bundesdruckerei übermitteln, wo im Auftrag des RKI die Daten zwischengespeichert und vom RKI täglich abgerufen werden. Die Gesamtzahl der Impfungen und die Tabelle werden bis mittags aktualisiert. Es kann vorkommen, dass Meldungen einzelner Bundesländer vervollständigt oder korrigiert werden. In die...

Verzögerung der Antikörperantwort liegen, wenn ich das als Amateur alles richtig verstanden habe.Falls das hier ein Experte liest, freue ich mich über Berichtigung! pic.twitter.com/7m08tnqFRp— Florian S (@Florian83616025) January 27, 2021

Ein Team um Viola Priesemann vom Max-Planck-Institut für Dynamik und Selbstorganisation hat eine Prognose berechnet, wie sich Maßnahmen gegen die Corona-Pandemie auf die Zahl der Neuinfektionen mit Sars-CoV-2 und die Zahl der Covid-19-Fälle in Deutschland auswirken.

1) So, this morning I promised a little tweetorial about variants and here we go. This will be from a vaccine/antibody point of view only, I won't comment on how infectious they are or if they are more pathogenic (I'll leave that to Boris Johnson 😉).— Florian Krammer (@florian_krammer) January 26, 2021

COVID-19 resources and guidelines for labs and laboratory workers.

We're publishing information on the numbers involved in the coronavirus outbreak.

Jeder kann sich irren. Wer aber heute immer noch die Gefährlichkeit von Corona leugnet, irrt nicht, sondern ignoriert die Fakten. Erschreckenderweise sind auch Ärzte im „Widerstand“ gegen die Corona-Maßnahmen. Warum dieses Verhalten langfristig schädlich ist.

Seit dem Ausbruch in Wuhan Anfang 2020 hat sich SARS-CoV-2 pandemisch ausgebreitet. Der Erreger wird hauptsächlich respiratorisch übertragen und führt vor allem bei älteren und vulnerablen Bevölkerungsgruppen zu zahlreichen Todesfällen. Seit kurzem...

Original Article from The New England Journal of Medicine — Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

AbstractBackground. It is currently unclear whether SARS-CoV-2 reinfection will remain a rare event, only occurring in individuals who fail to mount an effectiv

Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.

Correspondence from The New England Journal of Medicine — Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Blood samples from recovered patients suggest a powerful, long-lasting immune response, researchers reported.

Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that in a cohort of 350 SARS-CoV-2–uninfected individuals, a small proportion had circulating immunoglobulin G (IgG) antibodies that could cross-react with the S2 subunit of the SARS-CoV-2 spike protein (see the Perspective by Guthmiller and Wilson). By contrast, COVID-19 patients generated IgA, IgG, and IgM antibodies that recognized both the S1 and S2 subunits. The anti-S2 antibo...

The immune response to SARS-CoV-2 is critical in both controlling primary infection and preventing re-infection. However, there is concern that immune responses following natural infection may not be sustained and that this may predispose to recurrent infection. We analysed the magnitude and phenotype of the SARS-CoV-2 cellular immune response in 100 donors at six months following primary infection and related this to the profile of antibody level against spike, nucleoprotein and RBD over the previous six months. T-cell immune responses to SARS-CoV-2 were present by ELISPOT and/or ICS analy...

Figure has dropped by over a quarter in three months, fuelling concerns over reinfection

Though far from common, some patients developed worse symptoms the second time they became infected with Covid-19

Antibodies are a potential therapy for SARS-CoV-2, but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2, as well as during in vitro ...

Vaccinated people in Israel are less likely to test positive for SARS-CoV-2, but a population-wide effect will take time to become clear.

This article is updated daily. The table below shows confirmed cases of COVID-19 reinfection. The first confirmed case of reinfection was reported in Hong Kong in late August, and 33 others were reported over the next few months, along with thousands of suspected cases. People with SARS-CoV-2, the virus which causes COVID-19, may continue to […]