SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor - 2021.01.06.425392v1.full.pdf
Covid19-Sources
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an esca… | bioRxiv
Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human health due to the confirmed greater transmissibility of several of these new strains but, due to conformational changes induced by the mutations, may render first-wave SARS-CoV-2 convalescent sera, vaccine-induced antibodies, or recombinant neutralizing antibodies (nAbs) ineffective. To be able to assess the risk of viral escape from neutralization by first-wave antibodies, we leveraged our capability for Molecular Dynamic (MD) simulation of the spike receptor binding domain (S RBD) and its binding to human ...
(1) Beͫvͣaͬnͨd auf Twitter: "Sweden mortality from 1900 to 2020. This week's data update from SCB puts Sweden past a sad milestone: year 2020 recorded both the most excess *deaths* as well as the highest excess *mortality* (population adjusted) since the 1918 flu pandemic. Let this sink in. 1/n https://t.co/KsNFpyEtpP" / Twitter
Sweden mortality from 1900 to 2020.This week's data update from SCB puts Sweden past a sad milestone: year 2020 recorded both the most excess *deaths* as well as the highest excess *mortality* (population adjusted) since the 1918 flu pandemic.Let this sink in.1/n pic.twitter.com/KsNFpyEtpP— Beͫvͣaͬnͨd (@zorinaq) January 19, 2021
SIR-like Models for COVID-19
SIR-like Models for COVID-19 by Dr. Frank Nestel for Technical University of Denmark November 2020
0-preview-archive - SEPAR-model_Arxiv_version.pdf
Contain COVID-19
(2) Uri Shalit auf Twitter: "I’m seeing many discussions about the evidence for vaccine effectiveness in Israel. This is a thread with my thoughts on what we know and don’t know at this point. First some vaccination statistics: https://t.co/54HBmKosRZ 1/18" / Twitter
I’m seeing many discussions about the evidence for vaccine effectiveness in Israel. This is a thread with my thoughts on what we know and don’t know at this point. First some vaccination statistics:https://t.co/54HBmKosRZ1/18— Uri Shalit (@ShalitUri) January 20, 2021
Initial Israeli data: First Pfizer shot curbs infections by 50% after 14 days | The Times of Israel
Studies of hundreds of thousands of Israeli vaccinees provide real-world info on efficacy; but health official also warns 17% of current serious cases had already gotten 1st shot
Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study - The Lancet Infectious Diseases
Options to Reduce Quarantine for Contacts of Persons with SARS-CoV-2 Infection Using Symptom Monitoring and Diagnostic Testing | CDC
CDC recommends a quarantine period of 14 days. Based on local circumstances and resources, this page offers options to shorten quarantine.
RKI - Informationsmaterial zum Impfen - Kurz & Knapp: Faktenblätter zum Impfen
Um die impfende Ärzteschaft in ihrer täglichen Arbeit zu unterstützen, hat das Robert Koch-Institut kompakte Faktenblätter zum Impfen entwickelt. Bereits verfügbar sind die Faktenblätter als PDF für die HPV-Impfung, zur Herpes-zoster-Impfung, zur Masern-Impfung, zur Influenza-Impfung und zu "Impfungen in der Schwangerschaft". Neu ist nun das Faktenblatt "COVID-19-Impfung". Weitere Faktenblätter sind in Arbeit. Die Faktenblätter fassen kurz und knapp die wichtigsten Informationen zu einer Impfung zusammen und richten sich in erster Linie an Ärztinnen und Ärzte. Darüber hinaus können die Info...
Corona-Übersterblichkeit: So hat sich die Sterberate in Ihrem Bundesland verändert
Wie schlägt sich die Corona-Pandemie in der Sterbe-Statistik nieder? Vergleichen Sie die Zahlen der Bundesländer - und wo Deutschland international steht.
(3) Michael Oberst auf Twitter: "Das #NoCovid-Papier widerlegt die These, dass Kinder unter Schulschließungen mehr zu leiden hätten als unter Präsenzunterricht in der Pandemie. Angst vor Infektionen und die Belastungen der Quarantäne wirken sich negativ aus. 1/ https://t.co/Bd3hvGY1S6" / Twitter
Das #NoCovid-Papier widerlegt die These, dass Kinder unter Schulschließungen mehr zu leiden hätten als unter Präsenzunterricht in der Pandemie. Angst vor Infektionen und die Belastungen der Quarantäne wirken sich negativ aus. 1/ https://t.co/nvG9BRRZQF pic.twitter.com/Bd3hvGY1S6— Michael Oberst (@miob1781) January 19, 2021
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants | bioRxiv
To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected nearly 100 million individuals resulting in over two million deaths. Many vaccines are being deployed to prevent coronavirus disease-2019 (COVID-19) including two novel mRNA-based vaccines. These vaccines elicit neutralizing antibodies and appear to be safe and effective, but the precise nature of the elicited antibodies is not known. Here we report on the antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines. Consis...
Rtlive.de
Aktuelle Reproduktionszahl aller deutschen Bundesländer
(1) Matthias Linden auf Twitter: "1/ Ein bisschen #ZeroCovid Mathematik, weil diese bei all den gefühlten Wahrheiten etwas zu kurz kommt. a) Was unterscheidet die Inzidenz 50/100.000 von 25/100.000? Immerhin ist das ein Faktor 2?! b) Und um drei Schritte zu machen, was unterscheidet 50/100.000 von 5/100.000?" / Twitter
1/ Ein bisschen #ZeroCovid Mathematik, weil diese bei all den gefühlten Wahrheiten etwas zu kurz kommt.a) Was unterscheidet die Inzidenz 50/100.000 von 25/100.000?Immerhin ist das ein Faktor 2?!b) Und um drei Schritte zu machen, was unterscheidet 50/100.000 von 5/100.000?— Matthias Linden (@matthiaslinden) January 19, 2021
Statistik-Rätsel: Viele Corona-Tote in Sachsen unentdeckt?
Statistiker stoßen in Sachsen auf ein unerklärliches Phänomen: Es sterben viel mehr Menschen, und die Übersterblichkeit lässt sich nicht nur mit den bestätigten Corona-Toten erklären.
Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected nasal versus nasopharyngeal swab | medRxiv
Background Nasopharyngeal (NP) swab samples for antigen-detecting rapid diagnostic tests (Ag-RDTs) require qualified healthcare professionals and are frequently perceived as uncomfortable by patients. Methods We performed a manufacturer-independent, prospective diagnostic accuracy study, comparing professional-collected nasal mid-turbinate (NMT) to nasopharyngeal swab, using the test kits of a WHO-listed SARS-CoV-2 Ag-RDT (STANDARD Q COVID-19 Ag Test, SD Biosensor), which is also being distributed by Roche. Individuals with high suspicion for COVID-19 infection were tested. The reference st...
Covid Vaccine Deaths Rise in Norway Among Older People - Bloomberg
SARS-CoV-2 und HIV: Entscheidende Unterschiede - myPoint
Increased infections, but not viral burden, with a new SARS-CoV-2 variant | medRxiv
Background A new variant of SARS-CoV-2, B.1.1.7/VOC202012/01, was identified in the UK in December-2020. Direct estimates of its potential to enhance transmission are limited. Methods Nose and throat swabs from 28-September-2020 to 2-January-2021 in the UK’s nationally representative surveillance study were tested by RT-PCR for three genes (N, S and ORF1ab). Those positive only on ORF1ab+N, S-gene target failures (SGTF), are compatible with B.1.1.7/VOC202012/01. We investigated cycle threshold (Ct) values (a proxy for viral load), percentage of positives, population positivity and growth ra...
Effectiveness of Masks and Respirators Against Respiratory Infections in Healthcare Workers: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis quantified the protective effect of facemasks and respirators against respiratory infections among healthcare workers. Relevant articles were retrieved from Pubmed, EMBASE, and Web of Science. Meta-analyses were ...
A rapid systematic review of the efficacy of face masks and respirators against coronaviruses and other respiratory transmissible viruses for the community, healthcare workers and sick patients - ScienceDirect
The pandemic of COVID-19 is growing, and a shortage of masks and respirators has been reported globally. Policies of health organizations for healthca…
Low-cost measurement of face mask efficacy for filtering expelled droplets during speech | Science Advances
Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks reduces the likelihood for an infected person to spread the disease, but many of these mask designs have not been tested in practice. We have demonstrated a simple optical measurement method to evaluate the efficacy of masks to reduce the transmission of respiratory droplets during regular speech. In proof-of-principle studies, we compared a...
Efficacy of masks and face coverings in controlling outward aerosol particle emission from expiratory activities | Scientific Reports
The COVID-19 pandemic triggered a surge in demand for facemasks to protect against disease transmission. In response to shortages, many public health authorities have recommended homemade masks as acceptable alternatives to surgical masks and N95 respirators. Although mask wearing is intended, in part, to protect others from exhaled, virus-containing particles, few studies have examined particle emission by mask-wearers into the surrounding air. Here, we measured outward emissions of micron-scale aerosol particles by healthy humans performing various expiratory activities while wearing diff...
School risk calculations scrambled by fast-spreading virus strains | Science | AAAS
The Netherlands saw rapid spread through a school and into the community
Epidemiology of post-COVID syndrome following hospitalisation with coronavirus: a retrospective cohort study | medRxiv
Objectives The epidemiology of post-COVID syndrome (PCS) is currently undefined. We quantified rates of organ-specific impairment following recovery from COVID-19 hospitalisation compared with those in a matched control group, and how the rate ratio (RR) varies by age, sex, and ethnicity. Design Observational, retrospective, matched cohort study. Setting NHS hospitals in England. Participants 47,780 individuals (mean age 65 years, 55% male) in hospital with COVID-19 and discharged alive by 31 August 2020, matched to controls on demographic and clinical characteristics. Outcome measures Rate...
(12) Hannah 🦈 auf Twitter: "A doctor in Ireland: "We will inevitably lose a significant proportion of the health care workforce due to #LongCovid...We have doctors off on long-term sick leave because of long Covid...we may lose anywhere up to 15% of doctors in Northern Ireland by the time this is over." 1/" / Twitter
A doctor in Ireland: "We will inevitably lose a significant proportion of the health care workforce due to #LongCovid...We have doctors off on long-term sick leave because of long Covid...we may lose anywhere up to 15% of doctors in Northern Ireland by the time this is over." 1/— Hannah 🦈 (@ahandvanish) January 18, 2021
Full article: SARS-CoV-2 Antigen Rapid Immunoassay for Diagnosis of COVID-19 in the Emergency Department
SARS-CoV-2 Antigen Rapid Immunoassay for Diagnosis of COVID-19 in the Emergency Department. Biomarkers. Accepted 9 January 2021.
StefFun on Twitter
Also technisch gesehen können auch Geimpfte nach der zweiten Impfung symptomatisch erkranken. Ich würde annehmen, dass diese Personengruppe dann neue Infektionsketten —insbesondere bei der nicht geimpften Bevölkerung — starten kann. #Maas pic.twitter.com/awrs5Zm0Ap— StefFun (@StefFun) January 17, 2021