Mild primary or breakthrough sars co v 2 infection
Patients with long COVID can develop humoral autoimmunity after severe acute SARS-CoV-2 infection. However, whether similar increases in autoantibody responses occur after mild infection and whether vaccination prior to SARS-CoV-2 breakthrough infection can limit autoantibody responses is unknown. In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection. However, patients with long COVID and persistent neurologic and fatigue symptoms (neuro-PASC) have substantially higher autoantibody responses than convalescent control subjects at an average of 8 mo postinfection. Furthermore, high titers of systemic lupus erythematosus– and CNS-associated autoantibodies in patients with neuro-PASC are associated with impaired cognitive performance and greater symptom severity. In summary, we found that mild SARS-CoV-2 primary and breakthrough infections can induce persistent humoral autoimmunity in both patients with neuro-PASC and healthy COVID convalescents, suggesting that a reappraisal of mitigation strategies against SARS-CoV-2 is warranted to prevent transmission and potential development of autoimmunity.
Non-human primate model of long-COVID identifies immune associates of hyperglycemia
Nature Communications - After infection with SARS-CoV-2 a diverse set of symptoms remain or develop longer term in a condition termed long-CoVID, yet an accurate and tractable model has remained...
A new study suggests that the COVID-19 vaccine (mRNA vaccine) could be used therapeutically to address metabolic complications experienced among those with even if the vaccine is administered several days after infection. 1/
CDC-Empfehlungen für den COVID-19-Impfstoff von Moderna 2024-2025 und den COVID-19-Impfstoff von Pfizer-BioNTech 2024-2025
➡️ Der Impfschutz nimmt mit der Zeit ab, daher ist es wichtig, mit Ihrem -Impfstoff auf dem Laufenden zu bleiben.
➡️ Alle Personen ab 6 Monaten …
— Ralf Wittenbrink (@RWittenbrink)
🧵1/ A Significant surge in the number of people with a disability in the U.S.
The just released an analysis using data from the Current Population Survey (CPS), revealing some concerning trends. Here’s what they found:
— Ziyad Al-Aly, MD (@zalaly)
Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction
Communications Medicine - Jeong et al. report a series of COVID-19 patients with hearing- and balance-related symptoms. The authors show that human and mouse inner ear tissues, as well as human...
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19
This cohort study examines the association of in-hospital delirium with functional disability and cognitive impairment for the first 6 months after discharge among older adults (aged 60 years or older) hospitalized with COVID-19.
Dexamethasone is one of the most important drugs in the treatment of severe COVID19, but patients respond differently to the therapy.
Researchers have now discovered how the cortisone compound influences the impaired inflammatory response and which patients benefit from it. 1/
— Vipin M. Vashishtha (@vipintukur)
Commission finds COVID pandemic caused $18 trillion in economic damage to US
A report by the Heritage Foundation's Nonpartisan Commission on China and COVID-19 found that the economic damage to the U.S. caused by the pandemic exceeded $18 trillion.
A NEW paper shows the links between LongCOVID, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (ME/CFS) and COVID-19 post-vaccine syndromes. These diseases could have an autoimmune origin & 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐨𝐟 a 𝐇𝐲𝐩𝐨𝐜𝐨𝐫𝐭𝐢𝐬𝐨𝐥𝐞𝐦𝐢𝐜 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞 1/
Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization
The efficiency of virus internalization into target cells is a major determinant of infectivity. SARS-CoV-2 internalization occurs via S-protein-mediated cell binding followed either by direct fusion with the plasma membrane or endocytosis and subsequent fusion with the endosomal membrane. Despite the crucial role of virus internalization, the precise kinetics of the processes involved remains elusive. We developed a pipeline, which combines live-cell microscopy and advanced image analysis, for measuring the rates of multiple internalization-associated molecular events of single SARS-CoV-2-virus-like particles (VLPs), including endosome ingression, pH change, and nucleocapsid release. Our live-cell imaging experiments demonstrate that only a few minutes after binding to the plasma membrane, VLPs ingress into Rab5-negative endosomes via Dynamin-dependent scission. Less than two minutes later, the pH of VLPs drops below 5 followed by an increase in VLP speed, yet these two events are not interrelated. Nucleocapsid release from the VLPs occurs with similar kinetics to the pH drop, suggesting that VLP fusion occurs during endosome acidification. Neither Omicron mutations nor abrogation of the S protein polybasic cleavage site altered the rate of VLP internalization events, indicating that they do not affect these processes. Finally, we observe that VLP internalization occurs two to three times faster in VeroE6 than in A549 cells, which may contribute to the greater susceptibility of the former cell line to SARS-CoV-2 infection. Taken together, our precise measurements of the kinetics of VLP internalization-associated processes shed light on their contribution to the effectiveness of SARS-CoV-2 propagation in cells. Time-lapse videos of the studied internalization events can be accessed in the dedicated [COVIDynamics database][1]. ### Competing Interest Statement The authors have declared no competing interest. [1]: https://covidynamics.imb.bas.bg/
Frontiers | Personality factors and pandemic-related behaviors
Those who always wore masks were significantly higher in compassion for others and significantly lower in sadism compared to those who did not always wear masks. Those who always socially distanced (compared to those who did not) were significantly higher in openness, compassion for others, and conscientiousness. Those who hoarded were significantly lower in agreeableness than those who did not hoard.
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
Scientific Reports - Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
Immunoprofiles of COVID-19 uniquely differentiated from other viruses: A machine learning investigation of multiplex immunoassay data
Abstract. Cytokines and chemokines are vital in maintaining a healthy state by efficiently controlling invading microbes. In addition, the dysregulation of
DMZ – WELT ¦ Anton Aeberhard ¦ KOMMETAR In den letzten Wochen ist die Sorge um eine erneute Zunahme von COVID-19-Fällen weltweit gewachsen. Laut aktuellen Daten der Weltgesundheitsorganisation (WHO) stiegen die Krankenhauseinweisungen zwischen Ende Juni und Juli um elf Prozent, während die Intensivstationseinweisungen um drei Prozent zunahmen. Dr. Maria Van Kerkhove von der WHO erklärte, dass in 84 Ländern der Anteil positiver Tests auf SARS-CoV-2 kontinuierlich ansteigt. Auch die Zahl der COVID-bedingten Todesfälle ist um 26 Prozent gestiegen. Dennoch mahnt die WHO zur Vorsicht bei der Interpretation der Daten, da Testungen und Sequenzierungen in vielen Ländern zurückgegangen sind und Verzögerungen bei der Datenübermittlung auftreten. Globale Zunahme der Infektionen? Ziyad Al-Aly, ein Experte von der Washington University in St. Louis, USA, betont die Bedeutung, den Anstieg der Krankenhauseinweisungen ernst zu nehmen. Er verweist darauf, dass eine COVID-Welle in Singapur dem aktuellen Anstieg in den USA vorausging, und weist darauf hin, dass in vielen Ländern unzureichende Daten erfasst werden, was die Einschätzung der Lage erschwert. Positiv hervorzuheben ist jedoch, dass die Zahl der COVID-Krankenhausaufenthalte immer noch unter dem Niveau des letzten Winters liegt. Paul Hunter, Professor für Medizin an der University of East Anglia, führt dies auf die geringere Schwere der aktuellen Infektionen im Vergleich zum Beginn der Pandemie zurück. Neue Varianten als Treiber der Sommerwelle Der jüngste Anstieg der COVID-Fälle wird unter anderem auf neue Untervarianten, sogenannte FLiRTs, zurückgeführt. Diese sind Nachkommen der JN.1-Variante, einer Omikron-Abwandlung, die zusätzliche Mutationen aufweist. Die FLiRT-Varianten, darunter KP.2, KP.3 und JN.1.7.1, tragen Mutationen, die ihre Übertragbarkeit und möglicherweise ihre Fähigkeit, dem Immunsystem zu entgehen, beeinflussen. Die aktuellen Daten deuten jedoch nicht darauf hin, dass diese Varianten gefährlicher sind als frühere. Al-Aly mahnt zur Vorsicht und betont, dass es noch zu früh sei, um definitive Aussagen über die Gefährlichkeit der neuen Varianten zu treffen. Gründe für den Anstieg im Sommer Ein wesentlicher Faktor für den Anstieg der Infektionen scheint die nachlassende Immunität in der Bevölkerung zu sein. Die Immunität nach einer Infektion oder Impfung hält durchschnittlich vier bis sechs Monate an, sodass die durch frühere Impfungen oder Infektionen erworbene Immunität nun nachlässt. Besonders gefährdete Gruppen wie ältere Menschen sollten daher zusätzliche Vorsichtsmaßnahmen ergreifen, um sich vor einer Infektion zu schützen. Paul Hunter weist darauf hin, dass die meisten aktuellen COVID-Krankenhausaufenthalte in Großbritannien ältere oder gesundheitlich vorbelastete Menschen betreffen. Er rät diesen Personen, ihre Impfungen regelmäßig aufzufrischen, um den Schutz aufrechtzuerhalten. Fazit Auch wenn die Zahl der COVID-Infektionen im Sommer leicht angestiegen ist, bleibt die Situation unter Kontrolle. Es ist jedoch wichtig, wachsam zu bleiben und besonders gefährdete Gruppen zu schützen. Die fortlaufende Überwachung und Anpassung der Schutzmaßnahmen bleibt unerlässlich, um das Risiko weiterer Infektionswellen zu minimieren.
The public health and economic burden of long COVID in Australia, 2022–24: a modelling study
Objective To estimate the number of people in Australia with long COVID by age group, and the associated medium term productivity and economic losses. Study design Modelling study: a susceptible–e...
Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study - Clinical Epigenetics
Background The epigenetic status of patients 6-month post-COVID-19 infection remains largely unexplored. The existence of long-COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), suggests potential long-term changes. Long-COVID includes symptoms like fatigue, neurological issues, and organ-related problems, regardless of initial infection severity. The mechanisms behind long-COVID are unclear, but virus-induced epigenetic changes could play a role. Methods and results Our study explores the lasting epigenetic impacts of SARS-CoV-2 infection. We analyzed genome-wide DNA methylation patterns in an Italian cohort of 96 patients 6 months after COVID-19 exposure, comparing them to 191 healthy controls. We identified 42 CpG sites with significant methylation differences (FDR
New York – Obwohl Kinder und Jugendliche bei einer Infektion mit SARS-CoV-2 häufig keine Symptome zeigen oder nur leicht erkranken, können sie an Long COVID...
Characterizing Long COVID in Children and Adolescents
This observational cohort study examines the symptoms experienced by children after SARS-CoV-2 infection and how these symptoms differ by age (6-11 years vs 12-17 years).