Covid19-Sources

Noch immer sterben viele Menschen an Covid-19. Dabei übersteigt die Zahl der Sterbefälle die der Grippe-Toten bei Weitem.

The COVID-19 pandemic heightened interest in patterns and levels of ‘excess’ deaths, typically defined as deaths over the number that might be expected to occur in an ‘average’ year. But with

Communications Medicine - El-Medany, Adams, Blythe et al. Investigate whether the carotid chemoreflex could be a mechanism underlying unexplained breathlessness in non-hospitalised patients with...

Nature - Individuals with long COVID show marked biological changes in cortisol and immune factors relative to convalescent populations.

An infectious etiology of Alzheimer’s disease has been postulated for decades. It remains unknown whether SARS-CoV-2 viral infection is associated with increased risk for Alzheimer’s disease. In this retrospective cohort study of 6,245,282 older adul

In a recent study published in the Journal of Alzheimer’s Disease, researchers investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections could trigger the development of new-onset Alzheimer’s disease (AD)

Receipt of updated XBB1.5 vaccines 8-120 days earlier was associated with lower risk of severe acute respiratory syndrome coronavirus 2 infection, emergenc

COVID-19 leads to a sustained reduction of immune cells of the myeloid and lymphoid cell lineages even 10 months after the first infection. Ten months after the first infection, S- and RBD-specific I...

Oxford – Menschen, die eine schwere, hospitalisierungsbedürftige COVID-19-Infektion durchgemacht haben, weisen auch 2-3 Jahre danach häufig noch signifikante...

The mechanistic factors hypothesized to be key drivers for the loss of infectivity of viruses in the aerosol phase often remain speculative. Using a next-generation bioaerosol technology, we report measurements of the aero-stability of several SARS-CoV-2 ...

Evolutionary mechanisms; Genomic analysis; Microbial genomics

Die Folgen der Kontaktverbote in der Corona-Zeit gerade für Kinder werden immer deutlicher. Der Medizinische Dienst registriert einen sprunghaften Anstieg von Entwicklungsstörungen. Auf welche Symptome Eltern achten müssen.

When the global COVID-19 pandemic was declared in 2020, experts feared that the widespread lockdowns would adversely affect the mental health of young adults so strongly that it could increase...

Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarbecovirus may have the ability to infect lymphocytes…

Mega-thread 🧵 — Emmanuel (@ejustin46)

In a randomized trial of standard-risk adults, metformin decreased severe acute respiratory syndrome coronavirus 2 viral loads by an average of 0.56 log10

— Eric Topol (@EricTopol)

A clinical trial evaluating the safety and effectiveness of a nasal vaccine candidate known as MPV/S-2P to protect against COVID-19 recently began enrolling participants, the US National Institutes of Health (NIH) announced.

Virus and T cell inflammation persist in the tissues of patients with Long Covid.

A recent study investigated whether psychiatric and cognitive symptoms commence or persist beyond a year of COVID-19-related hospitalization.

Eine große Krankenkasse hat erhoben, wie gut Ärzte Long-Covid-Patienten therapieren und betreuen. Das Ergebnis zeigt, wie groß die Mängel sind. Die Politik handelt dennoch nicht.

Author summary In this paper, we directly linked SARS-2-S-triggered syncytium formation in the absence of infection with the ensuing induction of cellular senescence and its pathophysiological contribution to heart failure. We propose that both SARS-2-S expression and SARS-2-S protein internalization were sufficient to induce senescence in nonsenescent ACE2-expressing cells. This is important because of the persistent existence of SARS-2-S or extracellular vesicles containing SARS-2-S during the post-acute stages of SARS-CoV-2 infection in human subjects. In searching for the underlying molecular mechanisms determining syncytial fate, the formation of functional MAVS aggregates dependent on RIG-I was observed at an early stage during fusion and regulated the anti-death to senescence fate of SARS-2-S syncytia through the TNFα-TNFR2 axis. We also found impaired cardiac metabolism in SARS-2-S syncytia induced by condensed WNK1. However, syncytium formation or cellular senescence observed with the wild-type fusogenic S protein does not occur with the spike proteins produced by currently approved COVID-19 mRNA vaccines. Importantly, SARS-2-S-exacerbated heart failure could be largely rescued by WNK1 inhibitor, anti-syncytial drug or senolytic agent. Together, we suggest that rescuing metabolism dysfunction in senescent SARS-2-S syncytia should be taken into consideration in individuals with post-acute sequelae of COVID-19 (PASC).

Immer wieder gibt es Diskussionen darüber, ob die Menschen „mit“ oder „am“ Coronavirus gestorben sind. Eine Antwort liefert das Covid-19-Autopsie-Register, in dem die deutschlandweiten Obduktionsergebnisse von Corona-Toten erfasst werden. Forscher haben diese nun erstmals ausgewertet.

Author summary While the SARS-CoV-2 outbreak continues, the deployment of vaccines in many regions has blunted the severity of SARS-CoV-2 infections and decreased hospitalizations. However, the medium-term impacts of the duration of severity-blocking immunity, and its potential interactions with heterogeneous vaccine uptake (e.g. from vaccine hesitancy) or more robust vaccines, remain unknown. To titrate these effects, we use immuno-epidemiological models to examine potential future scenarios. We find that sufficient vaccine hesitancy (and correspondingly higher vaccination rates among adopters) can rapidly increase the fraction of individuals infected after waned severity-blocking immunity even when robust vaccines are deployed. This result underlines that pharmaceutical developments for broadly protective vaccines should be combined with campaigns to increase vaccine uptake globally. We also show that this fraction is highly dependent on underlying immune uncertainties, which illustrates the importance of accurately measuring immune parameters for proper prediction based on hospitalization data.