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Frontiers | Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection
Frontiers | Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection
Advanced age is associated with an increased susceptibility to Coronavirus Disease (COVID)-19 and more severe outcomes, although the underlying mechanisms ar...
·frontiersin.org·
Frontiers | Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection
Adults over the age of 75 are 140 times more likely to die from Covid-19 than people in younger age groups. Despite a strong epidemiological pattern, the core biological reasons behind the impact of aging remained elusive 1/
Adults over the age of 75 are 140 times more likely to die from Covid-19 than people in younger age groups. Despite a strong epidemiological pattern, the core biological reasons behind the impact of aging remained elusive 1/
— Vipin M. Vashishtha (@vipintukur)
·x.com·
Adults over the age of 75 are 140 times more likely to die from Covid-19 than people in younger age groups. Despite a strong epidemiological pattern, the core biological reasons behind the impact of aging remained elusive 1/
Reminder: COVID-19 und seine ungleiche Wirkung auf den Stoffwechsel der Lunge
Reminder: COVID-19 und seine ungleiche Wirkung auf den Stoffwechsel der Lunge
DMZ – WISSENSCHAFT ¦ Anton Aeberhard ¦ COVID-19, verursacht durch das Virus SARS-CoV-2, ist eine komplexe Krankheit, die in unterschiedlichem Schweregrad auftreten kann. Einige Betroffene bleiben asymptomatisch, während andere unter milden Symptomen wie Müdigkeit, Übelkeit und dem Verlust von Geschmack und Geruch leiden. In schweren Fällen kann es jedoch zu Hypoxie und akutem Atemnotsyndrom (ARDS) kommen, was letztlich zum Tod führen kann. Bis Ende 2023 verzeichnete die Weltgesundheitsorganisation weltweit über 700 Millionen COVID-19-Fälle, von denen 7 Millionen direkt auf die Infektion oder ihre Komplikationen zurückzuführen sind. SARS-CoV-2: Ein hochansteckendes und schnell mutierendes Virus SARS-CoV-2 ist bekannt für seine hohe Ansteckungsrate und die schnelle Mutation, was seine anhaltende Verbreitung trotz weitverbreiteter Impfstoffe erklärt. Selbst nach überstandener akuter Infektion berichten viele Patienten von anhaltender Müdigkeit, Atemnot, Brustschmerzen und der Entwicklung von Krankheiten wie Typ-2-Diabetes und posturalem orthostatischem Tachykardiesyndrom (POTS). Diese post-akuten Folgen, auch als "Long COVID" bekannt, sind bisher schlecht charakterisiert, was Diagnose, Prävention und Behandlung erschwert. Bedeutung der Metabolomik in der Forschung Der Metabolom, also die Gesamtheit der Moleküle mit einem Molekulargewicht unter 1500 Dalton in einem Organismus, ist äußerst sensibel gegenüber kleinen Veränderungen durch Alter, Geschlecht, Ernährung und Krankheiten. Daher ist die Metabolomik eine wertvolle Methode, um die Auswirkungen und Mechanismen von Krankheiten zu verstehen. Bisherige Studien zur Metabolomik haben sich meist auf Bioflüssigkeiten wie Plasma und Urin konzentriert. Diese können jedoch die heterogenen Stoffwechselprozesse in Organen nicht vollständig erfassen. Neue Erkenntnisse durch räumliche Metabolomik Eine aktuelle Studie, veröffentlicht auf bioRxiv, untersuchte die Auswirkungen von COVID-19 durch eine systematische räumliche Metabolomik-Analyse von Lungengewebe bei Mäusen, die mit einem für Mäuse adaptierten SARS-CoV-2-Stamm infiziert wurden. Diese Analyse offenbarte, dass COVID-19 den Stoffwechsel in verschiedenen Lungenregionen unterschiedlich beeinflusst. Besonders betroffen waren die peripheren Bereiche der unteren Lungenlappen, wo die stärksten metabolischen Veränderungen festgestellt wurden. Die Studie identifizierte signifikante Stoffwechselstörungen in den peripheren Lungengeweben, insbesondere bei Aminosäuren, Fettsäuren und Eicosanoiden. Diese Veränderungen waren in den peripheren Geweben stärker ausgeprägt als in den zentralen Geweben, was helfen könnte zu erklären, warum periphere Lungengewebe häufiger durch COVID-19 geschädigt werden. Implikationen für Long COVID und zukünftige Forschung Die räumliche Metabolomik enthüllte, dass nach überstandener akuter Infektion die Stoffwechselstörungen und die Viruslast in den Lungengeweben signifikant variierten. Diese Erkenntnisse könnten Wege zur besseren Charakterisierung und Behandlung von Long COVID eröffnen. Zukünftige Studien sollten daher auch den Stoffwechsel von Gehirn, Bauchspeicheldrüse und Herz untersuchen, um die vielfältigen Symptome von Long COVID besser zu verstehen. Die Studie zeigt, dass der Einsatz von räumlicher Metabolomik in der Forschung entscheidend sein kann, um die komplexen und lokalen Auswirkungen von COVID-19 auf den menschlichen Körper besser zu verstehen und gezielte Therapien zu entwickeln. Zur Studie
·dmz-news.eu·
Reminder: COVID-19 und seine ungleiche Wirkung auf den Stoffwechsel der Lunge
Corona löst Spermien-Selbstmord aus – Was das für Männer bedeutet
Corona löst Spermien-Selbstmord aus – Was das für Männer bedeutet
Forscher aus Brasilien konnten Sars-CoV-2 bis zu drei Monate nach einer Infektion im Sperma nachweisen. Sie stellten fest, dass durch das Corona-Virus eine schädliche Abwehrreaktion in Gang gesetzt wird, die Spermien schadet. Mit der Zeugung von Nachwuchs sollten betroffene Männer daher ein halbes Jahr warten.
·m.focus.de·
Corona löst Spermien-Selbstmord aus – Was das für Männer bedeutet
Long COVID and cardiovascular disease: a prospective cohort study
Long COVID and cardiovascular disease: a prospective cohort study
Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need. Trail registration number [ISRCTN10980107][1]. Data are available upon reasonable request. [1]: /external-ref?link_type=ISRCTN&access_num=ISRCTN10980107
·openheart.bmj.com·
Long COVID and cardiovascular disease: a prospective cohort study
New findings show risk of death from COVID-19 lessens, but infection still can cause issues three years later
New findings show risk of death from COVID-19 lessens, but infection still can cause issues three years later
New findings on long COVID—long-term effects on health experienced by many who have had COVID-19—present a good-news, bad-news situation, according to a study at Washington University School of Medicine ...
·medicalxpress.com·
New findings show risk of death from COVID-19 lessens, but infection still can cause issues three years later
Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other viruses
Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other viruses
A study has found that repeat vaccination with updated versions of the COVID-19 vaccine promotes the development of antibodies that neutralize a wide range of variants of the virus that causes COVID-19, as well as related coronaviruses.
·sciencedaily.com·
Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other viruses
Mandating indoor air quality for public buildings
Mandating indoor air quality for public buildings
People living in urban and industrialized societies, which are expanding globally, spend more than 90% of their time in the indoor environment, breathing indoor air (IA). Despite decades of research and advocacy, most countries do not have legislated indoor air quality (IAQ) performance standards for public spaces that address concentration levels of IA pollutants (1). Few building codes address operation, maintenance, and retrofitting, and most do not focus on airborne disease transmission. But the COVID-19 pandemic has made all levels of society, from community members to decision-makers, realize the importance of IAQ for human health, wellbeing, productivity, and learning. We propose that IAQ standards be mandatory for public spaces. Although enforcement of IAQ performance standards in homes is not possible, homes must be designed and equipped so that they could meet the standards.
·science.org·
Mandating indoor air quality for public buildings
Original research: Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection
Original research: Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection
Long COVID is associated with multiple symptoms and impairment in multiple organs. Cross-sectional studies have reported cardiac impairment to varying degrees by varying methodologies. Using cardiac MR (CMR), we investigated a 12-month trajectory of abnormalities ...
·ncbi.nlm.nih.gov·
Original research: Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection
Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18–24 Months Corrected Age: A Prospective Observational Study
Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18–24 Months Corrected Age: A Prospective Observational Study
Abstract. Introduction: During the early coronavirus disease (COVID-19) pandemic in 2020, researchers cautioned about the potential neuroinvasive capability of the virus and long-term neurological consequences. Although a few preliminary studies have found delayed communication, fine motor, and problem-solving skills in infants after COVID-19 infection, there continues to be a paucity of data on long-term development of neonates diagnosed with COVID-19. Methods: We conducted a prospective study of 20 neonates who acquired severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during the first wave of the pandemic (April–July 2020). At 18–24 months corrected age, we assessed neurodevelopment by Bayley Scales of Infant and Toddler Development, the third edition (BSID-III), along with growth, hearing, and vision evaluation. Results: The mean corrected age at assessment was 21 months 11 days ± 1 month 28 days. We found developmental delay in nearly half of the children with scores below one standard deviation in either of the BSID-III domains. Mild delay in either motor, cognitive, or language domains was found in 9 (45%) children and moderate delay in 2 (10%). Expressive language, fine motor, and receptive language were predominantly affected. None of the children had hearing impairment, blindness, or significant growth faltering including clinically severe microcephaly. The mean composite cognitive, language, and motor scores were significantly lower in those with neurodevelopmental delay (p value – 0.02, 0.000, and 0.03, respectively) without any differences in their disease characteristics. Conclusion: Neonates infected with SARS-CoV-2 have an increased risk of developmental delays in expressive language, fine motor, and receptive language skills at 18–24 months of age. The severity of delays is predominantly mild.
·karger.com·
Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18–24 Months Corrected Age: A Prospective Observational Study
Wer zu oft Wolf schreit…
Wer zu oft Wolf schreit…
Bis zur XBB.1.5-Welle im März 2023 waren meine Einschätzungen hinsichtlich neuer SARS-CoV2-Infektionswellen recht zuverlässig. Es gab naturgemäß bis zu diesem Zeitpunkt auch viel mehr Daten als heute und zumindest bis zum Winter schrieben auch die meisten ExpertInnen noch auf Twitter und wanderten nicht zu Mastodon oder woanders hin ab. Damit befand ich mich ziemlich im Einklang mit allen führenden Expertinnen und es gab eigentlich keine Überraschungen. Dann lehnte ich mich im März 2023 mit XBB.1.16 etwas zu weit aus dem Fenster – unglücklicherweise wurde ausgerechnet dieser Beitrag von einem reichweitenstarken Follower recht prominent repliziert, sodass nachträgliche Korrekturen nicht mehr sichtbar waren. Die große XBB.1.16-Welle fiel aus – andere Experten, mittlerweile nicht mehr auf Twitter vertreten, hatten frühzeitig abgewunken – zu groß die Kreuzimmunität durch BA.5 im Winter 2022/2023 und der erst eben abgelaufenen XBB.1.5-Welle. Aus Schaden wird man klug und seitdem bin ich deutlich vorsichtiger beim Ausrufen neuer Wellen. Zudem entledigte ich mich einiger Möchtegernexperten auf Twitter, die sich als „Große Klappe, nichts dahinter“ entlarvt hatten oder von seriösen ExpertInnen entlarvt wurden. Hochstapler gibt es leider nicht nur auf Seiten der Verharmloser, sondern auch auf der der „Doomer“. Friendly fire sozusagen, mit dem man sich unglaubwürdig macht.
·coronafakten.com·
Wer zu oft Wolf schreit…
Long COVID in a highly vaccinated but largely unexposed Australian population following the 2022 SARS-CoV-2 Omicron wave: a cross-sectional survey
Long COVID in a highly vaccinated but largely unexposed Australian population following the 2022 SARS-CoV-2 Omicron wave: a cross-sectional survey
To estimate the prevalence of long COVID among Western Australian adults, a highly vaccinated population whose first major exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was during the 2022 Omicron wave, and to assess its impact on health service use and return to work or study. Study design Follow-up survey (completed online or by telephone). Setting, participants Adult Western Australians surveyed 90 days after positive SARS-CoV-2 test results (polymerase chain reaction or rapid antigen testing) during 16 July – 3 August 2022 who had consented to follow-up contact for research purposes. Main outcome measures Proportion of respondents with long COVID (ie, reporting new or ongoing symptoms or health problems, 90 days after positive SARS-CoV-2 test result); proportion with long COVID who sought health care for long COVID-related symptoms two to three months after infection; proportion who reported not fully returning to previous work or study because of long COVID-related symptoms. Results Of the 70 876 adults with reported SARS-CoV-2 infections, 24 024 consented to contact (33.9%); after exclusions, 22 744 people were invited to complete the survey, of whom 11 697 (51.4%) provided complete responses. Our case definition for long COVID was satisfied by 2130 respondents (18.2%). The risk of long COVID was greater for women (v men: adjusted risk ratio [aRR], 1.5; 95% confidence interval [CI], 1.4–1.6) and for people aged 50–69 years (v 18–29 years: aRR, 1.6; 95% CI, 1.4–1.9) or with pre-existing health conditions (aRR, 1.5; 95% CI, 1.4–1.7), as well as for people who had received two or fewer COVID–19 vaccine doses (v four or more: aRR, 1.4; 95% CI, 1.2–1.8) or three doses (aRR, 1.3; 95% CI, 1.1–1.5). The symptoms most frequently reported by people with long COVID were fatigue (1504, 70.6%) and concentration difficulties (1267, 59.5%). In the month preceding the survey, 814 people had consulted general practitioners (38.2%) and 34 reported being hospitalised (1.6%) with long COVID. Of 1779 respondents with long COVID who had worked or studied before the infection, 318 reported reducing or discontinuing this activity (17.8%). Conclusion Ninety days after infection with the Omicron SARS-CoV-2 variant, 18.2% of survey respondents reported symptoms consistent with long COVID, of whom 38.7% (7.1% of all survey respondents) sought health care for related health concerns two to three months after the acute infection.
·onlinelibrary.wiley.com·
Long COVID in a highly vaccinated but largely unexposed Australian population following the 2022 SARS-CoV-2 Omicron wave: a cross-sectional survey
From Long COVID Odds to Lost IQ Points: Ongoing Threats You Don’t Know About
From Long COVID Odds to Lost IQ Points: Ongoing Threats You Don’t Know About
Stuck in a fog of misleading narratives, most of us don’t see the true extent of COVID's persisting—and intensifying—threats. INET’s Lynn Parramore talks to Dr. Phillip Alvelda about the dangers we’re missing and the failures of public health agencies to inform and protect us. *This is Part 1 of a two-part interview.
·ineteconomics.org·
From Long COVID Odds to Lost IQ Points: Ongoing Threats You Don’t Know About