Covid19-Sources

In vielen Ländern setzt sich gerade eine leicht mutierte Version von Sars-CoV-2 durch. Bislang gibt es allerdings nur wenig Anzeichen für eine Sommerwelle.

Nature Communications - COVID-19 vaccines reduce the risk of severe disease in young people, but the absolute risk is low, and side effects have been reported. Here, the authors use data on...

WastewaterSCAN Data Dashboard tracks infectious diseases across the US via wastewater surveillance.

Recent studies have unveiled a troubling connection between Covid-19 and cognitive decline that can cause a measurable decline.

Nature Communications - After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition with neurological symptoms. Here, the authors show symptom-specific brain...

Severe Avian Influenza A H5N1 Clade 2.3.4.4b Virus Infection in a Human with Continuation of SARS-CoV-2 Viral RNAs

In a recent study, published on May 27, 2024, the researchers report a human case with a co-infection with the clade 2.3.4.4b avian influenza A H5N1 virus and COVID-19. This case involved an elderly female farmer with multiple comorbidities who had a history of SARS-CoV-2 infection. This patient tested positive for COVID-19 on December 20, 2022, before her H5N1 infection. This study highlights the importance of surveillance for increased risk of H5N1 virus infection among individuals with post-COVID-19 conditions.

At present this seems the most likely successor to "FLiRT" KP.2 and "FLuQE" KP.3. 🧵 — Mike Honey (@Mike_Honey_)

My anaphylaxis is almost always cardiac & GI 🧵/1 — Kelly (@broadwaybabyto)

So, a bit of a review. I think this falls pretty solidly into the category of pseudoscience 1/n — Health Nerd (@GidMK)

DMZ – MEDIEN ¦ Anton Aeberhard ¦ KOMMENTAR Der Meinungsartikel "Impfgeschädigte warten in der Schweiz bis heute auf Genugtuung" auf SRF.ch präsentiert eine einseitige Darstellung, die auf Vermutungen und Behauptungen basiert, ohne ausreichende Fakten oder Daten zu liefern, um die Aussagen zu stützen. Darüber hinaus fehlt die Kennzeichnung als Meinungskommentar, was zu einer irreführenden Wahrnehmung beiträgt, wie die Kommentare unter dem Beitrag eindrücklich zeigen. Eine kritische Analyse dieses Artikels zeigt deutliche Mängel in der Berichterstattung. Zur Aufarbeitung gehört auch, solche Berichterstattungen kritisch zu sehen. Mangel an verifizierten Impfschäden Im Artikel werden Personen erwähnt, die angeblich unter schweren gesundheitlichen Problemen nach der Impfung leiden. Allerdings fehlen konkrete Nachweise für diese Behauptungen. Es wird nicht darauf hingewiesen, dass Impfschäden äußerst selten sind und von den meisten Experten als äußerst unwahrscheinlich betrachtet werden. Fehlende wissenschaftliche Beweise Der Kommentar liefert keine wissenschaftlichen Studien oder Daten, um die Behauptung zu stützen, dass Impfungen in der Schweiz zu schweren Gesundheitsschäden geführt haben. Zahlreiche Studien haben gezeigt, dass die Covid-19-Impfstoffe sicher und wirksam sind, und Millionen von Menschen weltweit ohne schwerwiegende Nebenwirkungen geimpft wurden. Einseitige Berichterstattung Der Artikel konzentriert sich ausschließlich auf die Berichte von Personen, die behaupten, Impfschäden erlitten zu haben, ohne alternative Perspektiven oder Expertenmeinungen einzubeziehen. Eine ausgewogene Berichterstattung sollte verschiedene Stimmen und Standpunkte berücksichtigen, um ein vollständiges Bild zu liefern. Fehlende Kontextualisierung Der Artikel erwähnt nicht die weit verbreitete Zustimmung von Experten und Gesundheitsbehörden zur Sicherheit und Wirksamkeit der Covid-19-Impfungen, noch die Faktenlage, dass der Impfstoff sicher ist und Impfschäden äußerst selten sind. Es fehlt die Kontextualisierung, dass die Vorteile der Impfung das Risiko von Nebenwirkungen bei weitem überwiegen und dass die Impfstoffe strengen Sicherheitsprüfungen unterzogen wurden, bevor sie zugelassen wurden. Insgesamt lässt die Berichterstattung des Artikels erhebliche Zweifel an seiner Glaubwürdigkeit und Objektivität aufkommen. Eine kritische Leserschaft sollte solche einseitigen Darstellungen skeptisch betrachten und nach fundierten Beweisen und Fakten verlangen, bevor sie solche Behauptungen akzeptiert. Diese Art der Berichterstattung ist nicht nur ungenau, sondern auch potenziell gefährlich, da sie falsche Annahmen vermitteln und Ängste schüren kann. Die Covid-19-Impfung ist sicher und wirksam und hat Millionen von Menschen weltweit das Leben gerettet. Eine verantwortungsvolle Berichterstattung sollte diese Tatsachen berücksichtigen und die Bedeutung von wissenschaftlicher Evidenz und Ausgewogenheit in der öffentlichen Kommunikation hervorheben. Wichtige Informationen: Pandemie: Eine Analyse des Schadens und der Notwendigkeit einer gründlichen Aufarbeitung covid-19 AND vaccination AND effectiveness - Search Results - PubMed (nih.gov) COVID-19-Impfstoffe wirksam gegen Long COVID und Komplikationen Kritischer Blick auf Fehlinformationen zu Post-Vac Causa Prof. Schieffer und das "PostVacSyndrom": Eine kritische Betrachtung Antivax-Propaganda als „Studie“ getarnt: Fake-Papier zu Impfschäden wurde endlich zurückgezogen Wissenschaftliche Klarheit: Entlarvung von Fehlinformationen über COVID-19-Impfstoffe Politik der Aufarbeitung: Ein Selbstlob trotz Pandemie-Versagen Fallstudie: Auswirkungen von 217 SARS-CoV-2-Impfungen auf das adaptive Immunsystem Studie zeigt: COVID-19-Impfung in der Schwangerschaft hat keine negativen Auswirkungen auf Neugeborene Post-Vac und Long-Covid müssen klar getrennt werden

Scientific Reports - Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero

The severe neurodevelopmental sequelae that were found in two neonates after in utero exposure to SARS-CoV-2

While considerable attention has been devoted to respiratory manifestations, such as pneumonia and acute respiratory distress syndrome (ARDS), emerging evidence underlines the significance of extrapulmonary involvement. In this study, we examined 15 hospitalized patients who succumbed to severe complications following SARS-CoV-2 infection. These patients were admitted to the Sibiu County Clinical Emergency Hospital in Sibiu, Romania, between March and October 2021. All patients were ethnic Romanians. Conducted within a COVID-19-restricted environment and adhering to national safety protocols, autopsies provided a comprehensive understanding of the disease’s multisystemic impact. Detailed macroscopic evaluations and histopathological analyses of myocardial, renal, hepatic, splenic, and gastrointestinal tissues were performed. Additionally, reverse transcription-quantitative polymerase chain reaction (rt-qPCR) assays and immunohistochemical staining were employed to detect the viral genome and nucleocapsid within the tissues. Myocardial lesions, including ischemic microstructural changes and inflammatory infiltrates, were prevalent, indicative of COVID-19’s cardiac implications, while renal pathology revealed the chronic alterations, acute tubular necrosis, and inflammatory infiltrates most evident. Hepatic examination identified hepatocellular necroinflammatory changes and hepatocytic cytopathy, highlighting the hepatic involvement of SARS-CoV-2 infection. Splenic parenchymal disorganization was prominent, indicating systemic immune dysregulation. Furthermore, gastrointestinal examinations unveiled nonspecific changes. Molecular analyses detected viral genes in various organs, with immunohistochemical assays confirming viral presence predominantly in macrophages and fibroblasts. These findings highlighted the systemic nature of SARS-CoV-2 infection, emphasizing the need for comprehensive clinical management strategies and targeted therapeutic approaches beyond respiratory systems.

— Vipin M. Vashishtha (@vipintukur)

We have discussed the LIGHTNING PROCESS before: The ‘Lightning Process’: implausible, unproven, hyped and expensive The ‘Lightning Process’ (LP), an effective therapy for ME? Now, the BBC reports that it is promoted as a treatment of Long-COVID. Oonagh Cousins was offered a free place on a course run by the Lightning Process, which teaches people

BackgroundEmerging evidence reveals that SARS-CoV-2 possesses the capability to disrupt the gastrointestinal (GI) homeostasis, resulting in the long-term sym...

Many COVID-19 patients suffer from gastrointestinal symptoms and impaired intestinal barrier function may play a key role in Long COVID. Despite its importance, the impact of SARS-CoV-2 on intestinal epithelia is poorly understood. To address this, we established an intestinal barrier model integrating epithelial Caco-2 cells, mucus-secreting HT29 cells and human Raji cells. This gut epithelial model allows efficient differentiation of Caco-2 cells into microfold-like cells, faithfully mimics intestinal barrier function, and is highly permissive to SARS-CoV-2 infection. Early strains of SARS-CoV-2 and the Delta variant replicated with high efficiency, severely disrupted barrier function, and depleted tight junction proteins, such as claudin-1, occludin and ZO-1. In comparison, Omicron subvariants also depleted ZO-1 from tight junctions but had fewer damaging effects on mucosal integrity and barrier function. Remdesivir and the TMPRSS2 inhibitor Camostat prevented SARS-CoV-2 replication and thus epithelial barrier damage, while the Cathepsin inhibitor E64d was ineffective. Our results support that SARS-CoV-2 disrupts intestinal barrier function but further suggest that circulating Omicron variants are less damaging than earlier viral strains. The data that support the findings of this study are openly available in Mendeley Data; DOI: 10.17632/n2cyh3pk4h.1.

COVID-19 has a wide range of clinical manifestations. Apart from respiratory symptoms, neurological manifestations and cognitive impairment are commonly seen. Due to lack of a clear consensus on the definition of long COVID a pragmatic approach of assessing change from neurological baseline has become prevalent. We present the case of a high functioning woman in her late 40s who had a mild course of acute illness but developed cognitive difficulties. No organic causes for her cognitive difficulties were found. Neuropsychological testing showed impairment in right frontal lobe functioning. The patient showed a response to empirical treatment with Attention deficit hyperactivity disorder (ADHD) medications. Repeat neuropsychological testing 1 year later showed continued dysfunction in executive functioning. We present the details of her test findings and discuss the proposed pathophysiology behind neurocognitive effects of long COVID.

Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chr...

The composition and function of the gut microbiota constantly influence health. Disruptions in this delicate balance, termed gut microbiota dysbiosis, have been implicated in various adverse health events. As the largest global epidemic since 1918, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had devastating consequences. While the primary impact of Corona Virus Disease 2019 (COVID-19) has been on the respiratory system, a growing body of research has unveiled the significant involvement of the gastrointestinal tract as well. Emerging evidence underscores notable alterations in the gut microbiome of COVID-19 patients. In addition, the gut microbiome is also characterized by an abundance of opportunistic pathogens, which is related to disease manifestations of COVID-19 patients. The intricate bidirectional interaction between the respiratory mucosa and the gut microbiota, known as the gut-lung axis, emerges as a crucial player in the pathological immune response triggered by SARS-CoV-2. Here, we discuss microbiota-based gut characteristics of COVID-19 patients and the long-term consequences of gut microbiota dysregulation. These insights could potentially transform the development of long-term interventions for COVID-19, offering hope for improved outcomes and enhanced patient recovery.

npj Vaccines - SARS-CoV-2 vaccination may mitigate dysregulation of IL-1/IL-18 and gastrointestinal symptoms of the post-COVID-19 condition

Auch lange nach den groß angelegten Impfungen gegen Covid-19 geistern Schauermeldungen über mögliche Folgen durch soziale Netzwerke. Bei genauerer Betrachtung bleibt davon oft wenig übrig.

Innerhalb kürzester Zeit gibt es deutlich mehr Pflegebedürftige. Dies wird sich wohl auf die Pflegeversicherung auswirken. Der Minister wirbt für einen anderen Umgang mit finanzieller Hilfe.

To study the association between COVID-19 vaccination and the risk of post-COVID-19 cardiac and thromboembolic complications. Methods We conducted a staggered cohort study based on national vaccination campaigns using electronic health records from the UK, Spain and Estonia. Vaccine rollout was grouped into four stages with predefined enrolment periods. Each stage included all individuals eligible for vaccination, with no previous SARS-CoV-2 infection or COVID-19 vaccine at the start date. Vaccination status was used as a time-varying exposure. Outcomes included heart failure (HF), venous thromboembolism (VTE) and arterial thrombosis/thromboembolism (ATE) recorded in four time windows after SARS-CoV-2 infection: 0–30, 31–90, 91–180 and 181–365 days. Propensity score overlap weighting and empirical calibration were used to minimise observed and unobserved confounding, respectively. Fine-Gray models estimated subdistribution hazard ratios (sHR). Random effect meta-analyses were conducted across staggered cohorts and databases. Results The study included 10.17 million vaccinated and 10.39 million unvaccinated people. Vaccination was associated with reduced risks of acute (30-day) and post-acute COVID-19 VTE, ATE and HF: for example, meta-analytic sHR of 0.22 (95% CI 0.17 to 0.29), 0.53 (0.44 to 0.63) and 0.45 (0.38 to 0.53), respectively, for 0–30 days after SARS-CoV-2 infection, while in the 91–180 days sHR were 0.53 (0.40 to 0.70), 0.72 (0.58 to 0.88) and 0.61 (0.51 to 0.73), respectively. Conclusions COVID-19 vaccination reduced the risk of post-COVID-19 cardiac and thromboembolic outcomes. These effects were more pronounced for acute COVID-19 outcomes, consistent with known reductions in disease severity following breakthrough versus unvaccinated SARS-CoV-2 infection.

Cognitive impairment is often reported after SARS-CoV-2 infection, yet evidence gaps remain. We aimed to (i) report the prevalence and characteristics…

SUMMARYThis narrative review and meta-analysis summarizes a broad evidence base on the benefits—and also the practicalities, disbenefits, harms and personal, sociocultural and environmental impacts—of masks and masking. Our synthesis of evidence from over ...