Covid19-Sources

Scientific Reports - The effect of the COVID-19 pandemic on life expectancy in 27 countries

The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national long...

Since their emergence in late 2021, SARS-CoV-2 Omicron replaced earlier variants of concern and marked a new phase in the SARS-CoV-2 pandemic. Until the end of 2023, Omicron lineages continue to circulate and continue to evolve, with new lineages causing infection waves throughout 2022 and 2023. In the population, this leads to a complex immunological exposure background, characterized by immunity derived through vaccination, in the 5th year of the pandemic in the majority of individuals followed by at least one or even multiple infections or only natural infection in individuals that did not receive a vaccine. In this study, we use eight authentic SARS-CoV-2 isolates (ancestral lineage B.1 and the seven Omicron lineages BA.1, BA.2, BA.5.1, BQ.1, XBB.1.5, EG.5.1 and JN.1.1) in a live virus neutralization assay to study immune escape in 97 human sera or plasma of different immunological backgrounds (vaccination, hybrid immunity due to one or two natural infections and natural infection without vaccination in children and adults). We showed a gradually increasing immune escape after vaccination and hybrid immunity in from B.1 to BA.1/BA.2 to BA.5.1 to BQ.1 to XBB.1.5 to EG.5.1, but remarkably, no more enhanced immune escape of JN.1.1 compared to EG.5.1, with the latter two showing almost identical neutralization titers in individuals with hybrid immunity due to one or more infections. In vaccinated but never infected individuals, neutralization was markedly reduced or completely lost for XBB.1.5., EG.5.1 and JN.1.1, while in those with hybrid immunity, titers were reduced but almost all sera still showed some degree of neutralization. After a single infection without vaccination, reduced or complete loss of neutralization occurred for BQ.1, XBB.1.5, EG.5.1 and JN.1.1 compared to BA.1/BA.2. Furthermore, we observed that, although absolute titers differed between groups, the pattern of immune escape between the variants remains comparable across groups, with strongest loss of neutralization for BQ.1, XBB.1.5, EG.5.1 and JN.1.1 was observed across the different immunological backgrounds. Our results show gradually increasing antibody escape of evolving Omicron lineages over the last two years of Omicron circulation until variant EG.5.1, but not anymore for the currently dominant lineages JN.1.1, suggesting other mechanisms than immune escape to be behind the rapid global emergence of JN.1. ### Competing Interest Statement IE has received research funding and speakers fees from Moderna for an unrelated research project (IIS). CSE received funding from Pfizer for an unrelated research project (IIS). All other authors: No conflict of interest.

Nature - Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.

#LongCovid #Leistungssport #COVIDistnichtMild - Kanutin Kriegerstein beendet KarriereStand: 17.08.2022 13:01 UhrDie Kanu-Olympia-Zweite von Rio de Janeiro, Steffi Kriegerstein, hat ihre Karriere wegen der Folgen einer Corona-Infektion beendet. Seehttps://t.co/EtxCSXdaov— Dr.med.Hank Schiffers, MD, MBA, Lean Sensei (@leanhealth) February 20, 2023

"Died Suddenly" features embalmers claiming that COVID-19 vaccines cause massive deadly clots, SBM has recruited an experienced embalmer to dissect the claims.

A study sheds further light on the risk of developing thrombosis with thrombocytopenia syndrome (TTS) after vaccination against the covid-19 virus.

By January 2022 over ten billion doses of COVID-19 vaccines had been administered worldwide. Concerns about COVID-19 vaccine-associated thrombosis aro…

This cohort study investigates the association of SARS-CoV-2 infection with risk of incident diabetes among individuals in Canada.

A University of British Columbia study looking at more than 600,000 people found a higher rate of diabetes in those who’d been infected with COVID-19.

Years of austerity, followed by Covid, have left Britain with unhealthy workers and businesses struggling to recruit, but the road to recovery, of all kinds, will be long

Nature Communications - Many viral infections are linked to the development of neurological disorders. Here, Balint et al use a mouse model of Zika virus infection to show that it is immune cells...

Long COVID was not associated with any one trimester of pregnancy.

Hospitals have become a strange new battleground in the fight against COVID, with doctors and public health experts concerned that too many patients are catching the virus — and an alarming number are dying — as a result of inadequate infection control.

Psychophysiology at the University of Tennessee in Knoxville in 2003. He then completed postdoctoral fellowships in pain medicine and neuroimaging at Arizona...

It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to the strong but ineffective inflammatory response ...

In 2023, roughly 1 in every 13 babies in Finland was born with a malformation, deformation, or chromosomal abnormality (Q00-Q99). The number of

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Recent evidence suggests that allergic asthma (AA) decreases the risk of Coronavirus Disease 2019 (COVID-19). However, the reasons remain unclear. Here, we systematically explored data from GWAS (18 cohorts with 11,071,744 samples), bulk transcriptomes (3 cohorts with 601 samples), and single-cell transcriptomes (2 cohorts with 29 samples) to reveal the immune mechanisms that connect AA and COVID-19. Two-sample Mendelian randomization (MR) analysis identified a negative causal correlation from AA to COVID-19 hospitalization (OR = 0.968, 95% CI 0.940–0.997, P = 0.031). This correlation was bridged through white cell count. Furthermore, machine learning identified dendritic cells (DCs) as the most discriminative immunocytes in AA and COVID-19. Among five DC subtypes, only conventional dendritic cell 2 (cDC2) exhibited differential expression between AA/COVID-19 and controls (P

As of June 2023, the majority of Canadians had been infected by the virus causing COVID-19. Most people recover from their symptoms and are able to carry on with their lives, however, for many others, symptoms persist for months, often impacting their ability to work and their quality of life overall.

The coronavirus disease 2019 (COVID-19) virus has been associated with heart disease. Reports have shown an increased incidence of arrhythmias following COVID-19. In fact, cardiac injury is suggested to be a driver of the arrhythmogenic substrate, and some case reports showed development of ventricular arrhythmias following COVID-19 in acute settings. However, recent literature is defining a new entity: long-haulers COVID, as many patients are reporting at least one residual symptom after COVID-19 resolution (1 ). In this context, we report the case of a patient who developed ventricular tachycardia after COVID-19 resolution, presenting as a cardiac manifestation of long-hauler COVID-19.

Los Angeles – Beim enzymatischen Abbau von SARS-CoV-2 entstehende Virusfragmente gleichen offenbar körpereigenen Peptiden, deren Aufgabe es ist, das Immunsystem... #PNASNews #COVID19

The ability of the new coronavirus SARS-CoV-2 to spread and contaminate is one of the determinants of the COVID-19 pandemic status. SARS-CoV-2 has been detected in saliva consistently, with similar sensitivity to that observed in nasopharyngeal swabs. We conducted ultrasound-guided postmortem biopsi …

In Rhineland-Palatinate, Germany, a system of three data sources has been established to track the Covid-19 pandemic. These sources are the number of Covid-19-related hospitalizations, the Covid-19 genecopies in wastewater, and the prevalence derived from a cohort study. This paper presents an extensive comparison of these parameters. It is investigated whether wastewater data and a cohort study can be valid surrogate parameters for the number of hospitalizations and thus serve as predictors for coming Covid-19 waves. We observe that this is possible in general for the cohort study prevalence, while the wastewater data suffer from a too large variability to make quantitative predictions by a purely data-driven approach. However, the wastewater data as well as the cohort study prevalence are able to detect hospitalizations waves in a qualitative manner. Furthermore, a detailed comparison of different normalization techniques of wastewater data is provided. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work has been supported by the Ministry for Science and Health of Rhineland-Palatinate. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes The cohort study data are presented online under . The number of N1 and N2 genecopies per ml in wastewater is publicly available online under . A slightly differently counted version of the number of hospitalizations than used for this paper is publicly available online under . The German weather data are publicly available online under .

Nature Immunology - Satija and colleagues use multimodal sequencing technologies and cross-modality integration tools to define distinct subpopulations of CD8+ T cells that are predictive of...

British Heart Foundation says its figures reveal ‘the worst heart care crisis in living memory’

We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with 60% of the ensuing serological response originating from the initial antibodies generated during the first exposure. We highlight one instance where hybrid immunity arising from breakthrough infection resulted in a marked increase in the breadth and affinity of a highly abundant vaccination-elicited plasma IgG antibody, SC27. With an intrinsic binding affinity surpassing a theoretical maximum (KD 5 pM), SC27 demonstrated potent neutralization of various SARS-CoV-2 variants and SARS-like zoonotic viruses (IC50 ∼0.1–1.75 nM) and provided robust protection in vivo . Cryo-EM structural analysis unveiled that SC27 binds to the RBD class 1/4 epitope, with both VH and VL significantly contributing to the binding interface. These findings suggest that exceptionally broad and potent antibodies can be prevalent in plasma and can largely dictate the nature of serological neutralization. ### Competing Interest Statement R.S.B., G.G., J.J.L., G.C.I., and W.N.V. are inventors on a provisional U.S. patent application for mAb SC27 and other new antibodies described in this manuscript, entitled "Broadly neutralizing human monoclonal antibodies that target the SARS-CoV-2 receptor binding domain (RBD)" (63/491,270).

Eine neue Studie aus den USA hat ergeben, dass Vegetarier und Veganer möglicherweise seltener an COVID-19 erkranken als Fleischesser. Erfahren Sie mehr.