FIGURE 2. Signs and symptoms* at hospital admission among symptomatic...
Download scientific diagram | Signs and symptoms* at hospital admission among symptomatic hospitalized pregnant women with COVID-19, † by pregnancy trimester -COVID-NET, 13 states, § March 1-August 22, 2020 from publication: Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020 | Pregnant women might be at increased risk for severe coronavirus disease 2019 (COVID-19) (1,2). The COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) (3) collects data on hospitalized pregnant women with laboratory-confirmed SARS-CoV-2, the virus that... | COVID-19, Pregnant Women and Hospitality | ResearchGate, the professional network for scientists.
Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RN…
Die Spezialisten vom Long-Covid Netzwerk Solothurn untersuchen Long-Covid Betroffene, schliessen andere Diagnosen aus und behandeln nach aktuellen Leitlinien und neuesten wissenschaftlichen Erkenntnisse essen, koordiniert durch die Neuropraxis Solothurn.
A Case Report: Long Post-COVID Vaccination Syndrome During the Eleven Months After the Third Moderna Dose
It is undisputed that anti-SARS-CoV-2 vaccines can have side effects. Long post-COVID vaccination syndrome (LPCVS) is one of them and is often neglected. It persists 11 months after the third mRNA-1273 (Moderna) vaccine dose has not been reported. Our ...
The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study
Cognitive deficits following SARS-CoV-2 infection were detectable nearly two years post infection, and largest for individuals with longer symptom durations, ongoing symptoms, and/or more severe infection. However, no such deficits were detected in individuals who reported full recovery from COVID-19. Further work is needed to monitor and develop understanding of recovery mechanisms for those with ongoing symptoms.
Nature Reviews Immunology - SARS-CoV-2 infection can lead to a diverse array of chronic symptoms, collectively termed ‘long COVID’. In this Review, Altmann and colleagues explore...
Nature Reviews Immunology - SARS-CoV-2 infection can lead to a diverse array of chronic symptoms, collectively termed ‘long COVID’. In this Review, Altmann and colleagues explore...
The US Department of Veteran Affairs health record data sets were used in a series of papers on altered risk conferred by COVID-19 on a wide range of disease outcomes, often viewed as HR deduced from 1-year disease burden data100,130,131,132,133. This finds an increased risk of dyslipidaemia across abnormal lipid outcomes, with a HR of 1.24 (ref. 131). Analysis of cardiovascular outcomes found a HR of 1.52 for risk of stroke, 2.93 for pulmonary embolism, 5.38 for myocarditis and 1.49 for transient ischaemic attacks130. For all diabetes across this data set, the HR was 1.4 (ref. 133).
Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial
148 participants were recruited (median age 14 years old, 62% female, 26% anti-nucleocapsid IgG seropositive pre-second dose); 132 participants received a second dose. Reactions were mostly mild-to-moderate, with lower rates in BNT-10 recipients. No vaccine-related serious adverse events occurred. Compared to BNT-30, at 28 days post-second dose anti-spike antibody responses were similar for NVX (adjusted geometric mean ratio [aGMR]) 1.09 95% confidence interval (CI): 0.84, 1.42] and lower for BNT-10 (aGMR 0.78 [95% CI: 0.61, 0.99]). For Omicron BA.1 and BA.2, the neutralising antibody titres for BNT-30 at day 28 were similar for BNT-10 (aGMR 1.0 [95% CI: 0.65, 1.54] and 1.02 [95% CI: 0.71, 1.48], respectively), but higher for NVX (aGMR 1.7 [95% CI: 1.07, 2.69] and 1.43 [95% CI: 0.96, 2.12], respectively). Compared to BNT-30, cellular immune responses were greatest for NVX (aGMR 1.73 [95% CI: 0.94, 3.18]), and lowest for BNT-10 (aGMR 0.65 [95% CI: 0.37, 1.15]) at 14 days post-second dose. Cellular responses were similar across the study arms by day 236 post-second dose. Amongst SARS-CoV-2 infection naïve participants, NVX participants had an 89% reduction in risk of self-reported ‘breakthrough infection’ compared to BNT-30 (adjusted hazard ratio [aHR] 0.11 [95% CI: 0.01, 0.86]) up until day 132 after second dose. BNT-10 recipients were more likely to have a ‘breakthrough infection’ compared to BNT-30 (aHR 2.14 [95% CI: 1.02, 4.51]) up to day 132 and day 236 post-second dose. Antibody responses at 132 and 236 days after second dose were similar for all vaccine schedules.
Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.529): a prospective cohort study from Shenzhen, China
Our data provide a comprehensive overview of the longitudinal viral and antibody dynamics of omicron variant in people with acute SARS-CoV-2 infection, with important implications for public health strategies, including population screening, antiviral treatment, isolation periods, and vaccination.
USA: Long COVID wird zunehmend in Todesbescheinigungen genannt
Hyattsville/Maryland – In den USA werden immer wieder Long-COVID-Symptome in den Sterbeurkunden erwähnt. Mitarbeiter des National Center for Health Statistics... #COVID19
Macrophages and Monocytes: “Trojan Horses” in COVID-19
We aimed to explore whether variants of SARS-CoV-2 (Chinese-derived strain (D614, lineage A), Italian strain PV10734 (D614G, lineage B.1.1) and Alpha strain (lineage B.1.1.7)) were able to infect monocytes (MN) and monocyte-derived macrophages (MDM) and ...
Teen Suicide Plummeted During Covid-19 School Closures, New Study Finds
A new study has tied suicide rates among children and teenagers directly to the school calendar, suggesting that academic and social stressors can be blamed for an annual increase in fall and spring suicide attempts.
Wirksamkeit der Corona-Maßnahmen: Viel hilft viel, oder?
Eine Studie des Robert Koch-Instituts zeigt, dass die Lockdowns in Deutschland wirksam waren. So weit, so klar. Trotzdem fördert die Studie etwas Überraschendes zutage.
ED Visits and Hospitalizations for Suicidality Among Children and Adolescents in the US, 2016 to 2021
This cross-sectional study uses administrative health claims data for emergency department (ED) visits and hospitalizations to examine recent trends in suicidality rates, quantify the seasonality in suicidality, and demonstrate the disrupted seasonality patterns during the spring 2020...
Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician
Current Atherosclerosis Reports - COVID-19 is now a global pandemic and the illness affects multiple organ systems, including the cardiovascular system. Long-term cardiovascular consequences of...
Penn Medicine Discovery Clarifies the Problem of T-Cell “Exhaustion” - Penn Medicine
“Our findings suggest that once T cells become exhausted, they remain fundamentally ‘wired’ to be exhausted—thus it may be hard to get them to become effective virus- and cancer-fighters again,” said study senior author E. John Wherry, PhD.
Cardiac abnormalities in Long COVID 1- year post-SARS- CoV-2 infection
Long COVID is associated with multiple
symptoms and impairment in multiple organs. Cross-
sectional studies have reported cardiac impairment
to varying degrees by varying methodologies. Using
cardiac MR (CMR), we investigated a 12-month
trajectory of abnormalities in Long COVID.
Objectives To investigate cardiac abnormalities 1-year
post-SARS- CoV-2 infection. Results Technical success of multiorgan and
CMR assessment in non- acute settings was 99.1%
and 99.6% at baseline, and 98.3% and 98.8% at
follow- up. Of individuals with Long COVID, 102/534
(19%) had CMR abnormalities at baseline; 71/102
had complete paired data at 12 months. Of those,
58% presented with ongoing CMR abnormalities at
12 months. High sensitivity cardiac troponin I and
B- type natriuretic peptide were not predictive of
CMR findings, symptoms or clinical outcomes. At
baseline, low LVEF was associated with persistent
CMR abnormality, abnormal GLS associated with
low quality of life and abnormal T1 in at least
three segments was associated with better clinical
outcomes at 12 months.
Conclusion CMR abnormalities (left entricular
or right ventricular dysfunction/dilatation and/
or abnormal T1mapping), occurred in one in five
individuals with Long COVID at 6 months, persisting
in over half of those at 12 months. Cardiac-
related blood biomarkers could not identify CMR
abnormalities in Long COVID.
SARS-CoV-2 kann das gefürchtete Guillain-Barré-Syndrom auslösen
Anfang April wurde erstmals die Möglichkeit eines SARS-CoV-2-assoziierten Guillain-Barré-Syndroms (GBS) in 'Lancet Neurology' diskutiert [1]. Kurz darauf folgten zwei weitere Publikationen aus Europa, die ein GBS bzw. eine GBS-Variante bei COVID-19-Patienten beschreiben [2, 3]. Das GBS entsteht häufig in Folge von Infektionen, z.B. nach bakterieller Darminfektion oder Infektion mit dem Zytomegalievirus.
Thanks to Arlene Harris for great coverage in today's @BelTelGood grief, I wish Rosie and I didn't have to keep doing this. But until we have #CleanAirForAll, we will keep making #LongCovidKids. So we will keep going... pic.twitter.com/mwlWgJUyrP— Colin Pidgeon #CleanAirForAll #fblc (@baldypidge) July 11, 2023
Long COVID in Young Patients: Impact on Lung Volume Evaluated Using Multidetector CT
Purpose: To evaluate using quantitative analysis on chest CT images a possible lung volume reduction in Long COVID patients who complain mild respiratory symptoms, with chest CT negative for inflammatory findings. Materials and Methods: CT images of patients from 18 to 40 years old who underwent chest CT scan at our institution were analyzed retrospectively, using AwServer Thoracic VCAR software for a quantitative study. Exclusion criteria were inflammatory findings at CT, previous lung surgery, lung cancer, and breath artifacts that invalidate the quality of images. Patients were divided into two groups: in the first one (“post-COVID”) were patients who had previous SARS-CoV-2 infection, confirmed by an RT-PCR, who underwent chest CT from 3 to 6 months after their negativization for long COVID symptoms; in the control group (“non-COVID”), were enrolled patients who underwent a chest CT scan from January 2018 to December 2019, before the spread of COVID in Italy. Results: Our final population included 154 TC, 77 post-COVID patients (mean age 33 ± 6) and 77 non-COVID patients (mean age 33 ± 4.9). Non statistical significative differences were obtained between groups in terms of age, sex, and other characteristics that affect total lung capacity such as obesity, thoracic malformations, and smoking habit. Mean values of the total lung volume (TV), right-lung volume (RV), and left-lung volume (LV) in the post-COVID group compared with non-COVID group were, respectively: 5.25 ± 0.25 L vs. 5.72 ± 0.26 L (p = 0.01); 2.76 ± 0.14 L vs. 3 ± 0.14 L (p = 0.01); 2.48 ± 0.12 L vs. 2.72 ± 0.12 L (p = 0.01). Conclusion: In patients with symptoms suggesting Long COVID and negative chest CT macroscopic findings, quantitative volume analysis demonstrated a mean value of reduction in lung volume of 10% compared to patients of the same age who never had COVID. A chest CT negative for inflammatory findings may induce clinicians to attribute Long COVID mild respiratory symptoms to anxiety, especially in young patients. Our study brings us beyond appearances and beyond the classic radiological signs, introducing a quantitative evaluation of lung volumes in these patients. It is hard to establish to what extent this finding may contribute to Long COVID symptoms, but this is another step to gain a wider knowledge of the potential long-term effects caused by this new virus.
