Covid19-Sources

4433 bookmarks
Custom sorting
Lung function decline in relation to COVID-19 in the general population: a matched cohort study with pre-pandemic assessment of lung function | The Journal of Infectious Diseases | Oxford Academic
Lung function decline in relation to COVID-19 in the general population: a matched cohort study with pre-pandemic assessment of lung function | The Journal of Infectious Diseases | Oxford Academic
AbstractObjective. To quantify the potential decline in dynamic lung volumes following coronavirus disease 2019 (COVID-19) in the general population.Methods. A
·academic.oup.com·
Lung function decline in relation to COVID-19 in the general population: a matched cohort study with pre-pandemic assessment of lung function | The Journal of Infectious Diseases | Oxford Academic
Discordant SARS-CoV-2 PCR and Rapid Antigen Test Results When Infectious: A December 2021 Occupational Case Series
Discordant SARS-CoV-2 PCR and Rapid Antigen Test Results When Infectious: A December 2021 Occupational Case Series
The performance of Covid-19 diagnostic tests must continue to be reassessed with new variants of concern. The objective of this study was to describe the discordance in saliva SARS-CoV-2 PCR and nasal rapid antigen test results during the early infectious period. We identified a high-risk occupational case cohort of 30 individuals with daily testing during an Omicron outbreak in December 2021. Based on viral load and transmissions confirmed through epidemiological investigation, most Omicron cases were infectious for several days before being detectable by rapid antigen tests. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement No funding was received to support this study. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Approved for research not involving human subjects by the SUNY Downstate Institutional Review Board & Privacy Board (1603504-6) I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All de-identified data and the code for analysis is available on GitHub at https://github.com/blythejane/covid_safety. https://github.com/blythejane/covid_safety
·medrxiv.org·
Discordant SARS-CoV-2 PCR and Rapid Antigen Test Results When Infectious: A December 2021 Occupational Case Series
(5) Ian Ricksecker auf Twitter: "PSA: COVID-19 isn’t “just a cold,” isn’t “a respiratory virus,” and “mild” doesn’t mean what you think it does. If you “aren’t scared of COVID”, this thread is for you. (1/🧵) Please R/T if it opens your eyes." / Twitter
(5) Ian Ricksecker auf Twitter: "PSA: COVID-19 isn’t “just a cold,” isn’t “a respiratory virus,” and “mild” doesn’t mean what you think it does. If you “aren’t scared of COVID”, this thread is for you. (1/🧵) Please R/T if it opens your eyes." / Twitter
PSA: COVID-19 isn’t “just a cold,” isn’t “a respiratory virus,” and “mild” doesn’t mean what you think it does. If you “aren’t scared of COVID”, this thread is for you. (1/🧵) Please R/T if it opens your eyes.
·twitter.com·
(5) Ian Ricksecker auf Twitter: "PSA: COVID-19 isn’t “just a cold,” isn’t “a respiratory virus,” and “mild” doesn’t mean what you think it does. If you “aren’t scared of COVID”, this thread is for you. (1/🧵) Please R/T if it opens your eyes." / Twitter
Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients infected between March 2020 and November 2021
Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients infected between March 2020 and November 2021
Background: Long COVID is a post-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection syndrome characterised by not recovering for several weeks or months following the acute episode. The effectiveness of COVID-19 vaccines against long-term symptoms of COVID19 is not well understood. We determined whether vaccination was associated with reporting long-term symptoms post-SARS-CoV-2 infection by comparing, among individuals previously infected with SARS-CoV-2, those who were vaccinated to those who were not, in terms of self-reported long-term symptoms. Methods: We invited individuals who were PCR tested for SARS-CoV-2 infection at participating hospitals between March 2020-June 2021 to fill an online questionnaire that included baseline demographics, details of their acute episode and information about symptoms they were currently experiencing. Using binomial regression, we compared vaccinated individuals with those unvaccinated in terms of self-reported symptoms post-acute infection. Results: Of 951 previously infected individuals who filled the survey 637(67%) were vaccinated. The most commonly reported symptoms were; fatigue (22%), headache (20%), weakness (13%), and persistent muscle pain (10%). After adjusting for follow-up time and baseline symptoms, fully vaccinated (2 or more doses) individuals were less likely than unvaccinated individuals to report any of these symptoms by 64%, 54%, 57%, and 68% respectively, (Risk ratios 0.36, 0.46, 0.43, 0.32, p0.04 in the listed sequence). Conclusions: Vaccination with at least two doses of COVID-19 vaccine was associated with a substantial decrease in reporting the most common post-acute COVID19 symptoms. Our results suggest that, in addition to reducing the risk of acute illness, COVID-19 vaccination may have a protective effect against long COVID. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study received ethical approvals from the Ziv Medical Centre, Padeh-Poriya Medical Centre, and Galilee Medical Centre ethical committees, reference numbers; 0007-21-ZIV, 009-21-POR, and 0018-21-NHR, respectively. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors
·medrxiv.org·
Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients infected between March 2020 and November 2021
Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France | Adolescent Medicine | JAMA | JAMA Network
Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France | Adolescent Medicine | JAMA | JAMA Network
This study examines the risk of multisystem inflammatory syndrome in children among those 12 years and older by COVID-19 vaccination status during September 2021 and October 2021 in France.
·jamanetwork.com·
Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France | Adolescent Medicine | JAMA | JAMA Network
COVID-19 vaccine safety updates: Primary series in children and adolescents ages 5–11 and 12–15 years, and booster doses in adolescents ages 16–24 years
COVID-19 vaccine safety updates: Primary series in children and adolescents ages 5–11 and 12–15 years, and booster doses in adolescents ages 16–24 years
Reports to VAERS after primary series Pfizer-BioNTech COVID-19 vaccination in children and adolescents ages 5–11 and 12–15 years  Reports to VAERS after Pfizer-BioNTech COVID-19 booster vaccination in adolescents ages 16–24 years
·cdc.gov·
COVID-19 vaccine safety updates: Primary series in children and adolescents ages 5–11 and 12–15 years, and booster doses in adolescents ages 16–24 years
2020 12 02 empfehlung viruzides gurgeln nasenspray
2020 12 02 empfehlung viruzides gurgeln nasenspray
Zur Prävention von COVID -19 müssen alle infrage kommenden hygienischen Präventionsmaßnahmen ausgeschöpft werden, um insbesondere das medizinische Personal, aber auch die übrige Bevölkerung zu schützen. Da ein großer Teil der Infizierten das Virus bereits vor Auftreten erster Symptome freisetzt, sind vor allem Schutzmaßnahmen sinnvoll, die die Viruslast an den Eintrittspforten reduzieren, da die Wahrscheinlichkeit einer Infektion mit der Exposition zunimmt und die anfängliche Viruslast Einfluss auf den Schweregrad der Infektion hat [1,2]. Antiseptisches Gurgeln und nasale Antiseptik sind zu Unrecht in Vergessenheit geratene simple Präventionsmaßnahmen. Gurgeln wurde lange Zeit zur Verringerung von Infektionen der oberen Atemwege und zur Behandlung bakterieller/viraler Infektionen (z.B. Halsentzündung, Erkältung) eingesetzt, ist aber aus der Mode gekommen. Das Händewaschen mit Wasser und Seife und das Gurgeln mit Kochsalzlösung wurden schon während der Spanischen Grippe 1918 der Bevölkerung in Deutschland vom Reichsgesundheitsrat als Präventionsmaßnahme empfohlen [3]. In der ehemaligen DDR wurde Schulkindern beim Eintritt ins Sommerferienlager empfohlen, mit verdünnter Kaliumpermanganatlösung (schwach rosa) zu gurgeln (eigenes Erleben). Heute wird Kaliumpermanganatlösung kaum noch eingesetzt, obwohl sie als 1%ige Mundspüllösung erhältlich ist. Im Unterschied zu Europa hat das tägliche Gurgeln in Japan ebenso wie in Korea zur Infektionsprävention respiratorischer Infektionen eine lange Tradition. 2009 wurde das Gurgeln vom japanischen Ministerium für Gesundheit, Arbeit und Wohlfahrt verstärkt während der H1N1-Schweinegrippe-Pandemie propagiert und wird erneut seit der COVID -19 Pandemie ausdrücklich der Bevölkerung zur täglichen Durchführung empfohlen. Bereits seit Jahrhunderten ist bekannt, dass salzhaltige Luft eine wohltuende, beruhigende Wirkung auf die Atemwege hat. Sie regt die natürliche Selbstreinigung der Atemwege an und beugt der Austrocknung der Schleimhäute vor. Zusätzlich wirkt die Befeuchtung der Schleimhäute von Mund und Nase der Anhaftung von Viren entgegen und ist daher selbst ohne Anwendung von Lösungen/Sprays mit viruzider Eigenwirkung präventiv wirksam [4, 5]. Um Gurgeln und Spülung der Nase als einfach realisierbare Bausteine zur Prävention und Kontrolle von COVID-19 in Deutschland zu nutzen, wird nachfolgend eine 07. Dezember 2020 2 kurzgefasste Zusammenstellung der bisherigen Kenntnisse zur viruziden W irkung und zu den präventiven Einsatzmöglichkeiten von Gurgellösungen und Nasensprays gegeben, um eine weitere Präventionsreserve auszuschöpfen und den Diskussionsprozess zu befördern. So wie mit Beginn der COVID-19 Pandemie soziale Abstandswahrung, Mund-Nasen-Schutz, Händedesinfektion und Belüftung von Innenräumen einen neuen Stellenwert in der Prävention innerhalb der Bevölkerung bekommen haben, sollte auch diese einfach handhabbare Möglichkeit der Prävention verstärkt genutzt werden.
·krankenhaushygiene.de·
2020 12 02 empfehlung viruzides gurgeln nasenspray
(16) Erin C. Sanders, MSN, WHNP-BC (She/Her) auf Twitter: "The fact that #Omicron doesn’t replicate as much in the lung doesn’t make me feel better. Why? #COVID19 was never just a respiratory disease, that’s its primary mode of transmission. I’m increasingly concerned about what this means for vasculature/clot presentation in particular." / Twitter
(16) Erin C. Sanders, MSN, WHNP-BC (She/Her) auf Twitter: "The fact that #Omicron doesn’t replicate as much in the lung doesn’t make me feel better. Why? #COVID19 was never just a respiratory disease, that’s its primary mode of transmission. I’m increasingly concerned about what this means for vasculature/clot presentation in particular." / Twitter
The fact that #Omicron doesn’t replicate as much in the lung doesn’t make me feel better. Why? #COVID19 was never just a respiratory disease, that’s its primary mode of transmission. I’m increasingly concerned about what this means for vasculature/clot presentation in particular.
·twitter.com·
(16) Erin C. Sanders, MSN, WHNP-BC (She/Her) auf Twitter: "The fact that #Omicron doesn’t replicate as much in the lung doesn’t make me feel better. Why? #COVID19 was never just a respiratory disease, that’s its primary mode of transmission. I’m increasingly concerned about what this means for vasculature/clot presentation in particular." / Twitter
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection | Journal of Translational Medicine | Full Text
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection | Journal of Translational Medicine | Full Text
Background Pronounced sex differences in the susceptibility and response to SARS-CoV-2 infection remain poorly understood. Emerging evidence has highlighted the potential importance of autoimmune activation in modulating the acute response and recovery trajectories following SARS-CoV-2 exposure. Given that immune-inflammatory activity can be sex-biased in the setting of severe COVID-19 illness, the aim of the study was to examine sex-specific autoimmune reactivity to SARS-CoV-2 in the absence of extreme clinical disease. Methods In this study, we assessed autoantibody (AAB) reactivity to 91 autoantigens previously linked to a range of classic autoimmune diseases in a cohort of 177 participants (65% women, 35% men, mean age of 35) with confirmed evidence of prior SARS-CoV-2 infection based on presence of antibody to the nucleocapsid protein of SARS-CoV-2. Data were compared to 53 pre-pandemic healthy controls (49% women, 51% men). For each participant, socio-demographic data, serological analyses, SARS-CoV-2 infection status and COVID-19 related symptoms were collected by an electronic survey of questions. The symptoms burden score was constructed based on the total number of reported symptoms (N = 21) experienced within 6 months prior to the blood draw, wherein a greater number of symptoms corresponded to a higher score and assigned as more severe burden. Results In multivariable analyses, we observed sex-specific patterns of autoreactivity associated with the presence or absence (as well as timing and clustering of symptoms) associated with prior COVID-19 illness. Whereas the overall AAB response was more prominent in women following asymptomatic infection, the breadth and extent of AAB reactivity was more prominent in men following at least mildly symptomatic infection. Notably, the observed reactivity included distinct antigens with molecular homology with SARS-CoV-2. Conclusion Our results reveal that prior SARS-CoV-2 infection, even in the absence of severe clinical disease, can lead to a broad AAB response that exhibits sex-specific patterns of prevalence and antigen selectivity. Further understanding of the nature of triggered AAB activation among men and women exposed to SARS-CoV-2 will be essential for developing effective interventions against immune-mediated sequelae of COVID-19.
·translational-medicine.biomedcentral.com·
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection | Journal of Translational Medicine | Full Text
Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Impfungen sind extrem sicher. Trotzdem muss man festhalten: Es gibt kein Nullrisiko. Auch eine Impfung ist ein medizinischer Eingriff, und somit kann es wie nach jeder medizinischen Handlung zu Reaktionen kommen („keine Wirkung ohne Nebenwirkung“), dabei ist wichtig, dass das Verhältnis von Nutzen und Risiko aber immer zugunsten des Nutzens liegt. Das oberste Gebot der Medizin...
·reisemed.at·
Impfreaktion – Nebenwirkung - Impfzentrum Alserstraße
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.
·nature.com·
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)
·twitter.com·
Emanuel Wyler auf Twitter: "#CoronaInfo – Wie genau die verschiedenen Arten von Corona-Impfstoffen wirken, wird zur Zeit intensiv erforscht. In einem Projekt, das von einer Forschungsgruppe des Paul-Ehrlich-Instituts getragen wird, untersuchen wir, ob bestimte Impfstoffe sogar schaden könnten. … (1/8)" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV
·twitter.com·
(1) Anthony J Leonardi, PhD, MS auf Twitter: "Among 177 healthcare workers, ALL of them had persistent self-attacking antibodies that persisted at least 6 months after infection regardless of illness severity This is very unexpected https://t.co/2EQrfl8OEV" / Twitter
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
Doctors in Norway have been told to conduct more thorough evaluations of very frail elderly patients in line to receive the Pfizer BioNTec vaccine against covid-19, following the deaths of 23 patients shortly after receiving the vaccine. “It may be a coincidence, but we aren’t sure,” Steinar Madsen, medical director of the Norwegian Medicines Agency (NOMA), told The BMJ . “There is no certain connection between these deaths and the vaccine.” The agency has investigated 13 of the deaths so far and concluded that common adverse reactions of mRNA vaccines, such …
·bmj.com·
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9
·twitter.com·
(11) Eric Topol auf Twitter: "Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9" / Twitter
Self-assembling protein nanoparticles in the design of vaccines
Self-assembling protein nanoparticles in the design of vaccines
For over 100 years, vaccines have been one of the most effective medical interventions for reducing infectious disease, and are estimated to save millions of lives globally each year. Nevertheless, many diseases are not yet preventable by vaccination. ...
·ncbi.nlm.nih.gov·
Self-assembling protein nanoparticles in the design of vaccines
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6
·twitter.com·
(1) Sigrid Neuhauser auf Twitter: "Pandemie, Endemie, Epedemie bezeichnen Unterschiede in der Zirkulation verschiedener Erreger, diese Begriffe sagen nichts über die Schwere der Krankheiten aus! Endemisch bedeutet dass ein Erreger dauerhaft in hoher Anzahl in der Bevölkerung zirkuliert. 1/6" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms
·twitter.com·
(1) Anthony J Leonardi, PhD, MS auf Twitter: "People that are advocating for school openings aren't advocating for clean air and masks enough It's not right to expect people to catch this every year Reinfections have been equal and worse, not always milder probably due to autoabs to immune proteins among other mechanisms" / Twitter
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
Eine überstandene Covid-19 Erkrankung bedeutet nicht immer, auch restlos gesund zu sein. Wir möchten mit den Selbsthilfegruppen und allen Betroffenen sowie deren Angehörigen, einen Rahmen geben, in dem es möglich ist, auf Augenhöhe miteinander umzugehen. Im Austausch von gesammelten Erfahrungen, liegt für jeden Einzelnen ein großes Potential, seinen Weg besser zu finden.
·leben-mit-covid.de·
Interessenvertretung Post-Covid-Erkrankter e.V. – Verein zur Unterstützung Post-Covid-Erkrankter
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that contribute to escape from the neutralizing antibody responses, and reducing vaccine protection from infection. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, and in unvaccinated convalescent COVID-19 patients (n = 70). We found that 70-80% of the CD4 and CD8 T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar to that of the Beta and Delta variants, despite Omicron harbouring considerably more mutations. Additionally, in Omicron-infected hospitalized patients (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those found in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). These results demonstrate that despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell response, induced by vaccination or natural infection, cross-recognises the variant. Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19, supporting early clinical observations from South Africa. ### Competing Interest Statement A. Sette is a consultant for Gritstone Bio, Flow Pharma, Arcturus Therapeutics, ImmunoScape, CellCarta, Avalia, Moderna, Fortress and Repertoire. All of the other authors declare no competing interests. LJI has filed for patent protection for various aspects of vaccine design and identification of specific epitopes. ### Funding Statement Research reported in this publication was supported by the South African Medical Research Council (SA-MRC) with funds received from the South African Department of Science and Innovation, including grants 96825, SHIPNCD 76756 and DST/CON 0250/2012. This work was also supported by the Poliomyelitis Research Foundation (21/65) and the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), which is supported by core funding from the Wellcome Trust (203135/Z/16/Z and 222574). This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N93021C00016 to A.S. and Contract No. 75N9301900065 to A.S, D.W. P.L.M. is supported by the South African Research Chairs Initiative of the Department of Science and Innovation and the National Research Foundation (NRF; Grant No 9834). W.A.B. and C.R. are supported by the EDCTP2 programme of the European Union's Horizon 2020 programme (TMA2017SF-1951-TB-SPEC to C.R. and TMA2016SF-1535-CaTCH-22 to W.A.B.). N.A.B.N acknowledges funding from the SA-MRC, MRC UK, NRF and the Lily and Ernst Hausmann Trust. A.S. acknowledges funding from the Bill and Melinda Gates award INV-018944, the NIH (AI138546) and the South African Medical Research Council. R.J.W. acknowledges funding from the Francis Crick Institute, which receives funding from Wellcome FC0010218, UKRI FC0010218 and CRUK FC0010218 and the Rosetrees Trust grant M926 (to C.R. and R.J.W.). For the purposes of open access, the authors have applied a CC-BY public copyright license to any author-accepted version arising from this submission. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study was approved by the University of Cape Town Human Research Ethics Committee (ref: HREC 190/2020 and 209/2020) and the University of the Witwatersrand Human Research Ethics Committee (Medical) (ref. M210429 and M210752), the Biomedical Research Ethics Committee at the University of KwaZulu-Natal (ref.BREC/00001275/2020) and the University of Pretoria Health Sciences Research Ethics Committee (ref. 247/2020). I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors
·medrxiv.org·
SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
Brain imaging before and after COVID-19 in UK Biobank
Brain imaging before and after COVID-19 in UK Biobank
There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. The vast majority of brain imaging studies so far have focused on qualitative, gross pathology of moderate to severe cases, often carried out on hospitalised patients. It remains unknown however whether the impact of COVID-19 can be detected in milder cases, in a quantitative and automated manner, and whether this can reveal a possible mechanism for the spread of the disease. UK Biobank scanned over 40,000 participants before the start of the COVID-19 pandemic, making it possible to invite back in 2021 hundreds of previously-imaged participants for a second imaging visit. Here, we studied the effects of the disease in the brain using multimodal data from 782 participants from the UK Biobank COVID-19 re-imaging study, with 394 participants having tested positive for SARS- CoV-2 infection between their two scans. We used structural and functional brain scans from before and after infection, to compare longitudinal brain changes between these 394 COVID- 19 patients and 388 controls who were matched for age, sex, ethnicity and interval between scans. We identified significant effects of COVID-19 in the brain with a loss of grey matter in the left parahippocampal gyrus, the left lateral orbitofrontal cortex and the left insula. When looking over the entire cortical surface, these results extended to the anterior cingulate cortex, supramarginal gyrus and temporal pole. We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison, with, in addition, a greater loss of grey matter in the cingulate cortex, central nucleus of the amygdala and hippocampal cornu ammonis (all |Z|3). Our findings thus consistently relate to loss of grey matter in limbic cortical areas directly linked to the primary olfactory and gustatory system. Unlike in post hoc disease studies, the availability of pre- infection imaging data helps avoid the danger of pre-existing risk factors or clinical conditions being mis-interpreted as disease effects. Since a possible entry point of the virus to the central nervous system might be via the olfactory mucosa and the olfactory bulb, these brain imaging results might be the in vivo hallmark of the spread of the disease (or the virus itself) via olfactory and gustatory pathways. All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprintthis version posted June 15, 2021.;https://doi.org/10.1101/2021.06.11.21258690doi:medRxiv preprint
·medrxiv.org·
Brain imaging before and after COVID-19 in UK Biobank