Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials
Background: Fruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using ...
Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study
Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent.
Research question Are UPF associated with an increased risk of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)?
Methods Data of participants in this study were collected from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Dietary intakes were assessed through a validated diet history questionnaire. These foods were categorised using the NOVA classification according to the degree of processing in the PLCO Cancer Screening Cohort. All cases of incident lung cancer were pathologically verified. Multivariable Cox regression was used to assess the association between consumption of UPF and lung cancer after adjustment for various potential confounders, including key risk factors related to lung cancer and overall diet quality.
Results A total of 1706 cases of lung cancer cases, including 1473 NSCLC and 233 SCLC, were identified during a mean follow-up of 12.2 years among 101 732 adults (mean age 62.5 years). After multivariable adjustments, individuals in the highest quarters for UPF consumption had a higher risk of lung cancer (HR=1.41, 95% CI 1.22 to 1.60), NSCLC (HR=1.37, 95% CI 1.20 to 1.58) and SCLC (HR=1.44, 95% CI 1.03 to 2.10) compared with those in the lowest quarter. These results remained statistically significant after a large range of subgroup and sensitivity analyses.
Conclusions Higher consumption of UPF is associated with an increased risk of lung cancer, NSCLC and SCLC. Although additional research in other populations and settings is warranted, these findings suggest the healthy benefits of limiting UPF.
Data may be obtained from a third party and are not publicly available. Data described in the manuscript, code book and analytic code will not be made available because the authors are prohibited from distributing or transferring the data and code books on which their research was based to any other individual or entity under the terms of an approved NCI Research Proposal and Data and Materials Distribution Agreement through which the authors obtained these data.
Astaxanthin, a Natural Antioxidant, Lowers Cholesterol and Markers of Cardiovascular Risk in Individuals with Prediabetes and Dyslipidemia
Astaxanthin is a natural carotenoid with antioxidant and anti-inflammatory effects. We conducted a double blind, placebo-controlled, randomized trial to determine the effects of astaxanthin treatment on lipids, CVD markers, glucose tolerance, ...
Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin
Astaxanthin (3,3′-dihydroxy-4,4′-diketo-β-β carotene), which belongs to the xanthophyll class, has shown potential biological activity in in vitro and in vivo models including as a potent antioxidant, anti-lipid peroxidation and cardiovascular ...
Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers
Background and Objective Astaxanthin is a naturally occurring carotenoid with high anti-oxidant properties, but it is a very lipophilic compound with low oral bioavailability. This study was conducted to compare the pharmacokinetic parameters of a novel astaxanthin preparation based on micellar solubilization technology, NovaSOL® 400-mg capsules (Test product), and those of astaxanthin 400-mg capsules (reference product), after single oral dose administration to healthy male adults. Methods A single oral dose (400 mg equivalent to 8 mg astaxanthin) of test and reference astaxanthin were administered with 240 mL of water to 12 volunteers according to crossover design, in two phases, with a washout period of 1 week in between. Blood samples were collected at hourly intervals for the first 12 h, then at 24.0, 48.0, and 72.0 h after administration. Aliquots of plasma were centrifuged and the clear supernatant was injected into the high performance liquid chromatography–diode array detection (HPLC-DAD) system. Plasma concentration of astaxanthin versus time profiles were constructed, and the primary pharmacokinetic parameters, maximum concentration (Cmax), area under concentration time curve from time of administration (0) to time (t) [AUC0-t] or to infinity ∞, [AUC0-∞], half-life (T½) and time to reach Cmax (Tmax) were calculated. Results The test micellar astaxanthin reached a Cmax of 7.21 µg/ml after 3.67 h compared to only 3.86 µg/ml after 8.5 h for the reference native astaxanthin. Conclusion Micellar formulation of astaxanthin is capable of producing a high concentration of astaxanthin in plasma in a shorter time, thereby expected to provide faster potential therapeutic efficacy.
A randomized, double-blind, positive-controlled, prospective, dose-response clinical study to evaluate the efficacy and tolerability of an aqueous extract of Terminalia bellerica in lowering uric acid and creatinine levels in chronic kidney disease subjects with hyperuricemia
Hyperuricemia is an independent risk factor in chronic kidney disease (CKD). Allopurinol and febuxostat are prescription medicines used to treat hyperuricemia but suffer side-effects. Earlier clinical study has shown that an aqueous extract of ...
An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery
Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhibiting proteolytic gene expression. Some evidence indicates that glycine supplementation may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve sleep quality and recovery. This literature review critically explores glycine’s potential as an ergogenic aid and its relevance to muscle regeneration, muscle strength, endurance exercise performance, and sleep quality. It also underscores key areas for future research. It is concluded that more randomized controlled clinical trials in humans are needed to confirm glycine’s potential as a dietary supplement to support muscle function, recovery, and overall athletic performance as an ergogenic aid and to establish nutritional recommendations for athletic performance. Also, it is essential to consider that high doses (500 mg/kg of body mass) could induce cytotoxic effects and contribute to acute glutamate toxicity.
Keywords: human metabolism, physical exercise, sports medicine, athletic performance, oxidative stress, muscle function
The effects of Tai Chi exercise on body composition and cardiorespiratory fitness in Chinese university students with obesity: A quasi experiment study
Scientific Reports - The effects of Tai Chi exercise on body composition and cardiorespiratory fitness in Chinese university students with obesity: A quasi experiment study
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
As a fibrinolytic enzyme from fermented soybean, nattokinase has been shown to be potentially beneficial for cardiovascular health, but current clinical evidences regarding the nattokinase supplementation on cardiovascular risk factors are various. ...
Ingwer und Kurkuma. Diese beiden Heilpflanzen haben mehr gemeinsam, als Sie denken, doch ihre Unterschiede in der Wirkung auf Gesundheit sind entscheidend.
Liver supplements may lower the risk of liver disease and improve or protect liver health if you have an existing condition. Learn if they can also detoxify.
Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin
Luteolin is a flavone which occurs in medicinal
plants as well as in some vegetables and spices.
It is a natural anti-oxidant with less pro-oxidant
potential than the flavonol quercetin, the best
studied flavonoid, but apparently with a better
safety profile. It displays excellent radical scav-
enging and cytoprotective properties, especially
when tested in complex biological systems
where it can interact with other anti-oxidants
like vitamins. Luteolin displays specific anti-in-
flammatory effects at micromolar concentrations
which are only partly explained by its anti-oxi-
dant capacities. The anti-inflammatory activity
includes activation of anti-oxidative enzymes,
suppression of the NF
κB pathway and inhibition
of pro-inflammatory substances. In vivo, luteolin
reduced increased vascular permeability and was
effective in animal models of inflammation after
parenteral and oral application. Although luteolin
is only a minor component in our nutrition (less
than 1 mg/day) epidemiological studies indicate
that it has the potential to protect from diseases
associated with inflammatory processes such as
cardiovascular disease. Luteolin often occurs in
the form of glycosides in plants, but these are
cleaved and the aglycones are conjugated and me-
tabolized after nutritional uptake which has to be
considered when evaluating in vitro studies. Some
data for oral and topical bioavailability exist, but
more quantitative research in this field is needed
to evaluate the physiological and therapeutical po-
tential of luteolin.
Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications.
KEYWORDS: Apigenin, cancer, flavonoids, oxidative stress, chronic diseases, bioactive compounds, inflammation
Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
Apigenin, a natural flavonoid prevalent in a variety of fruits, vegetables, and herbs, has attracted significant interest due to its wide range of pharmacological effects and therapeutic potential. This review aims to provide an in-depth analysis of apigenin from both preclinical and clinical perspectives, emphasizing its diverse roles in health management and disease treatment. Preclinical research highlights apigenin's effectiveness across numerous biological processes, including its anti-inflammatory, antioxidant, anti-cancer, anti-diabetic, neuroprotective, cardioprotective, and antimicrobial properties. The compound exerts its effects through the modulation of various signaling pathways, enzyme activities, gene expression, and cellular mechanisms. Apigenin's capacity to inhibit tumor growth, induce apoptosis, and suppress angiogenesis and metastasis points to its significant anti-cancer potential. Additionally, emerging clinical studies are beginning to affirm apigenin's therapeutic benefits, showing positive effects in treating cancer, cardiovascular diseases, diabetes, neurodegenerative disorders, and inflammatory conditions. Clinical trials have evaluated apigenin's safety, bioavailability, and efficacy, shedding light on its pharmacokinetics and pharmacodynamics. The review also addresses the challenges and opportunities within apigenin research, such as its limited bioavailability, potential drug interactions, and the need for standardized formulations. It discusses strategies to improve apigenin's bioavailability, including nanoformulations and combination therapies. In summary, this comprehensive review synthesizes current knowledge on apigenin, focusing on its extensive pharmacological activities and therapeutic promise. Future research and clinical trials are necessary to better understand apigenin’s mechanisms of action, refine therapeutic dosing, and confirm its efficacy across various diseases, ultimately facilitating its application in clinical settings.
Psyche und Herz schützen: Kann der Vagusnerv helfen?
Frankfurt/Main/Tübingen (tmn) - Stress, Angst, Depression – all das belastet nicht nur die Psyche, sondern auch das Herz: «Zahlreiche wissenschaftliche
Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: A randomized controlled trial - PubMed
TRF plus a low-sugar diet can reduce adiposity and improve liver, lipid, and inflammatory markers in patients with NAFLD.
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches
Supplementation with the natural senolytic agent fisetin attenuated age-related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cel...
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test), while meclizine (Mec), an mTORC1 inhibitor, extended the ...
Fisetin is a senotherapeutic that extends health and lifespan
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic ...
Each compound is given in the diet at the following levels (part per million -ppm- which is defined as milligrams of agent per kilogram of food). All testing is Stage I unless otherwise indicated.
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic …
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence - PubMed
Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related arterial dysfunction, in part, by promoting oxidative stress and inflammation, which reduce the bioavailability of the vasodilatory molecule nitric oxide (NO). In the present study, we assessed the …
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches - PubMed
Excess cellular senescence contributes to age-related increases in frailty and reductions in skeletal muscle strength. In the present study, we determined the efficacy of oral intermittent treatment (1 week on-2 weeks off-1 week on) with the natural flavonoid senolytic fisetin to improve frailty and …
Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial
To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms
and frequencies of administration.
Methods: A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-
over study with 2 × 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months
each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU
monthly). Main inclusion criteria were a vitamin D serum value 50 nmol/l and age ≥ 18 years. Primary endpoint
was adherence, secondary endpoints were preferences and vitamin D serum levels.
Results: The focus group reached consensus for preference of a monthly administration of solid forms to adults.
Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5–100.0%)
than weekly (66.4–98.1%) administration. Vitamin D levels increased significantly (p 0.001) in all participants. An
optimal value of 75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation
was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of
participants.
Conclusions: Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the
participants. However, only one third of study participants achieved values in the optimal range of 75 nmol/l
cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.
Keywords: Cholecalciferol, Oral intermittent treatment, Adherence, Preference, Formulation, Dosage frequency
Efficacy of daily versus intermittent administration of iron supplementation in anemia or blood indices during pregnancy
Background: Pregnant women take iron supplements in order to prevent iron deficiency anemia which may have undesirable effects for both the mother and fetus. This study aimed to compare the daily and intermittent dose of iron supplementation in ...
Inwieweit Nahrungsergänzungsmittel mit Arginin therapeutisch sinnvoll sind, wird derzeit intensiv erforscht. Herz-Kreislauf und Gefäße, Potenz und Bodybuilding sind die Hauptthemen. Welche Ergebnisse liegen derzeit vor?
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants
Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown to have antiatherosclerotic and lipid-lowering effects. However, data on human clinical studies are limited. In this clinical study involving 1,062 ...