Health

Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications. KEYWORDS: Apigenin, cancer, flavonoids, oxidative stress, chronic diseases, bioactive compounds, inflammation

Apigenin, a natural flavonoid prevalent in a variety of fruits, vegetables, and herbs, has attracted significant interest due to its wide range of pharmacological effects and therapeutic potential. This review aims to provide an in-depth analysis of apigenin from both preclinical and clinical perspectives, emphasizing its diverse roles in health management and disease treatment. Preclinical research highlights apigenin's effectiveness across numerous biological processes, including its anti-inflammatory, antioxidant, anti-cancer, anti-diabetic, neuroprotective, cardioprotective, and antimicrobial properties. The compound exerts its effects through the modulation of various signaling pathways, enzyme activities, gene expression, and cellular mechanisms. Apigenin's capacity to inhibit tumor growth, induce apoptosis, and suppress angiogenesis and metastasis points to its significant anti-cancer potential. Additionally, emerging clinical studies are beginning to affirm apigenin's therapeutic benefits, showing positive effects in treating cancer, cardiovascular diseases, diabetes, neurodegenerative disorders, and inflammatory conditions. Clinical trials have evaluated apigenin's safety, bioavailability, and efficacy, shedding light on its pharmacokinetics and pharmacodynamics. The review also addresses the challenges and opportunities within apigenin research, such as its limited bioavailability, potential drug interactions, and the need for standardized formulations. It discusses strategies to improve apigenin's bioavailability, including nanoformulations and combination therapies. In summary, this comprehensive review synthesizes current knowledge on apigenin, focusing on its extensive pharmacological activities and therapeutic promise. Future research and clinical trials are necessary to better understand apigenin’s mechanisms of action, refine therapeutic dosing, and confirm its efficacy across various diseases, ultimately facilitating its application in clinical settings.

Frankfurt/Main/Tübingen (tmn) - Stress, Angst, Depression – all das belastet nicht nur die Psyche, sondern auch das Herz: «Zahlreiche wissenschaftliche

Learn about the stages of dementia and the scales used to measure the progression of Alzheimer’s and other dementias: the FAST, GDS and CDR scales

TRF plus a low-sugar diet can reduce adiposity and improve liver, lipid, and inflammatory markers in patients with NAFLD.

Supplementation with the natural senolytic agent fisetin attenuated age-related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cel...

In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test), while meclizine (Mec), an mTORC1 inhibitor, extended the ...

Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic ...

Each compound is given in the diet at the following levels (part per million -ppm- which is defined as milligrams of agent per kilogram of food). All testing is Stage I unless otherwise indicated.

Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic …

Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related arterial dysfunction, in part, by promoting oxidative stress and inflammation, which reduce the bioavailability of the vasodilatory molecule nitric oxide (NO). In the present study, we assessed the …

Excess cellular senescence contributes to age-related increases in frailty and reductions in skeletal muscle strength. In the present study, we determined the efficacy of oral intermittent treatment (1 week on-2 weeks off-1 week on) with the natural flavonoid senolytic fisetin to improve frailty and …

To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration. Methods: A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross- over study with 2 × 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value 50 nmol/l and age ≥ 18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels. Results: The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5–100.0%) than weekly (66.4–98.1%) administration. Vitamin D levels increased significantly (p 0.001) in all participants. An optimal value of 75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants. Conclusions: Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of 75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU. Keywords: Cholecalciferol, Oral intermittent treatment, Adherence, Preference, Formulation, Dosage frequency

Background: Pregnant women take iron supplements in order to prevent iron deficiency anemia which may have undesirable effects for both the mother and fetus. This study aimed to compare the daily and intermittent dose of iron supplementation in ...

Inwieweit Nahrungsergänzungsmittel mit Arginin therapeutisch sinnvoll sind, wird derzeit intensiv erforscht. Herz-Kreislauf und Gefäße, Potenz und Bodybuilding sind die Hauptthemen. Welche Ergebnisse liegen derzeit vor?

Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown to have antiatherosclerotic and lipid-lowering effects. However, data on human clinical studies are limited. In this clinical study involving 1,062 ...

Nattokinase: A Natural Enzyme for Cardiovascular Health Nattokinase, an enzyme derived from the traditional Japanese dish natto (fermented soybeans), has been gaining attention for its potential health benefits, particularly in the realm of cardiovascular health. This unique enzyme is celebrated for its fibrinolytic

Schwarzer Tee ist aromatisch, überall erhältlich und ein sehr gesundes Getränk.

Recent studies in animals have shown a mechanistic link between intestinal microbial metabolism of the choline moiety in dietary phosphatidylcholine (lecithin) and coronary artery disease through the production of a proatherosclerotic metabolite, ...

PDF | In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline... | Find, read and cite all the research you need on ResearchGate

A tree called Terminalia bellirica which falls in the Combretaceae family, is usually called Bahera or Beleric myrobalan. For a long time, people in ancient medicine, mainly Ayurveda, have used nushu to help with many kinds of illnesses. We have examined how T. bellerica protects against free radicals and helps control inflammatory problems related to chronic illnesses. Terminalia bellirica’s strong anti-inflammatory and antioxidant effects are due to its flavonoids, gallic acid, ellagic acid, tannins and other phenolic compounds. As such, it is believed to help treat diseases like diabetes, heart disease, various disorders of the nervous system and problems of the respiratory system that involve inflammation and stress from oxidative agents. It sums up recent findings on the medicinal plant and suggests research directions needed to better use its medicinal properties.

Terminalia bellirica, commonly referred to as Balela, is a plant belonging to the Combretaceae family, which has been extensively employed in both preventative and therapeutic medicine. In Unani medicine, it is a widely used herbal drug for the treatment of several ailments, including obesity, atherosclerosis, gastrointestinal disorders, memory loss, premature greying of hair, weakened immune system, loss of eyesight, general weakness, and ageing. The present review article aims to provide a comprehensive account of Terminalia bellirica, describing its medicinal uses, pharmacological actions, therapeutic properties, and chemical constituents. Furthermore, the article provides an overview of the plant's properties. The study highlights the potential of Terminalia bellirica as a valuable source of medicinal compounds, which can be harnessed for the development of novel therapeutic agents.

Terminalia bellerica (T. bellerica) is a tree belonging to the family Combretaceae. In Ayurvedic system of medicine, it is used as "health-harmonizer" in combination with Terminalia chebula and Emblica officnalis. It is a large deciduous tree found all over in Asia, mostly native to Sri Lanka. Traditionally, T. bellerica is used for treatment of various diseases such as conjunctivitis, asthma, migraine, baldness, constipation and weak eyesight. It contains various phytoconstituents such as glycosides, flavonoids, tannins, phenolic compound, amino acids and saponins which are responsible for various pharmacological activities like anti-diabetic, anti-microbial, anti-salmonella, anti-biofilm, anticancer, hepatoprotective, anti-pyretic and anti-diarrheal. This review article provides comprehensive information on pharmacognostic, phytochemical and pharmacological properties of T. bellerica, as a source for further research studies.

1. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium succinate (MPSS) and an oral dose of 20 mg methylprednisolone as 4 x 5 mg tablets. ...

The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous ...

In this second installment about narcissism, we will explore the eight different types of narcissists. This is based on Dr. Ramani Durvasula’s work and book, titled “’Don’t You Know Who I Am?’ How to stay sane in an era of narcissism, entitlement, and incivility,” as well as Dr. Ramani’s videos on YouTube.

Are narcissists more prone to dementia? Unraveling the link between narcissism and heightened dementia risk, this article delves into the impact of self-centered traits on cognitive health. Discover how chronic stress and isolation exacerbate cognitive decline, and learn about brain-healthy practices to mitigate these risks. Explore practical steps and future research avenues to combat cognitive decline in narcissistic individuals.

Traits of narcissism may be adaptive or maladaptive. On a spectrum, narcissism can be overt, covert, antagonistic, communal, or malignant.

Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study - Volume 11