Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
Recent studies in animals have shown a mechanistic link between intestinal microbial metabolism of the choline moiety in dietary phosphatidylcholine (lecithin) and coronary artery disease through the production of a proatherosclerotic metabolite, ...
PDF | In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline... | Find, read and cite all the research you need on ResearchGate
Antioxidant and Anti-Inflammatory Properties of Terminalia Bellirica: A Comprehensive Review of its Therapeutic Potential in Chronic Disease Management
A tree called Terminalia bellirica which falls in the Combretaceae family, is usually called Bahera or Beleric myrobalan. For a long time, people in ancient
medicine, mainly Ayurveda, have used nushu to help with many kinds of illnesses. We have examined how T. bellerica protects against free radicals and helps
control inflammatory problems related to chronic illnesses. Terminalia bellirica’s strong anti-inflammatory and antioxidant effects are due to its flavonoids, gallic
acid, ellagic acid, tannins and other phenolic compounds. As such, it is believed to help treat diseases like diabetes, heart disease, various disorders of the nervous
system and problems of the respiratory system that involve inflammation and stress from oxidative agents. It sums up recent findings on the medicinal plant and
suggests research directions needed to better use its medicinal properties.
EFFICACY OF TERMINALIA BELLIRICA (Balela): A REVIEW
Terminalia bellirica, commonly referred to as Balela, is a plant belonging to the Combretaceae family, which has
been extensively employed in both preventative and therapeutic medicine. In Unani medicine, it is a widely
used herbal drug for the treatment of several ailments, including obesity, atherosclerosis, gastrointestinal
disorders, memory loss, premature greying of hair, weakened immune system, loss of eyesight, general
weakness, and ageing. The present review article aims to provide a comprehensive account of Terminalia
bellirica, describing its medicinal uses, pharmacological actions, therapeutic properties, and chemical
constituents. Furthermore, the article provides an overview of the plant's properties. The study highlights the
potential of Terminalia bellirica as a valuable source of medicinal compounds, which can be harnessed for the
development of novel therapeutic agents.
A pharmacognostic phytochemical and pharmacological review of terminalia bellerica
Terminalia bellerica (T. bellerica) is a tree belonging to the family Combretaceae. In Ayurvedic system of medicine, it is used as "health-harmonizer" in combination with Terminalia chebula and Emblica officnalis. It is a large deciduous tree found all over in Asia, mostly native to Sri Lanka. Traditionally, T. bellerica is used for treatment of various diseases such as conjunctivitis, asthma, migraine, baldness, constipation and weak eyesight. It contains various phytoconstituents such as glycosides, flavonoids, tannins, phenolic compound, amino acids and saponins which are responsible for various pharmacological activities like anti-diabetic, anti-microbial, anti-salmonella, anti-biofilm, anticancer, hepatoprotective, anti-pyretic and anti-diarrheal. This review article provides comprehensive information on pharmacognostic, phytochemical and pharmacological properties of T. bellerica, as a source for further research studies.
Methylprednisolone pharmacokinetics after intravenous and oral administration
1. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium succinate (MPSS) and an oral dose of 20 mg methylprednisolone as 4 x 5 mg tablets. ...
Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 am versus 4 pm
The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous ...
In this second installment about narcissism, we will explore the eight different types of narcissists. This is based on Dr. Ramani Durvasula’s work and book, titled “’Don’t You Know Who I Am?’ How to stay sane in an era of narcissism, entitlement, and incivility,” as well as Dr. Ramani’s videos on YouTube.
Are Narcissists at Higher Risk for Dementia? Exploring the Connection and Brain-Healthy Tips - Mind
Are narcissists more prone to dementia? Unraveling the link between narcissism and heightened dementia risk, this article delves into the impact of self-centered traits on cognitive health. Discover how chronic stress and isolation exacerbate cognitive decline, and learn about brain-healthy practices to mitigate these risks. Explore practical steps and future research avenues to combat cognitive decline in narcissistic individuals.
Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study | Journal of Nutritional Science | Cambridge Core
Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study - Volume 11
Kurkuma ist eine erstaunliche Pflanzenart mit einem weiten Spektrum für gesundheitliche Vorteile. Ein Beitrag von mir zählt das breit gefächerte Spektrum von Wirksamkeiten von Kurkuma auf:
A pilot study on the serum pharmacokinetics of nattokinase in humans following a single, oral, daily dose - PubMed
These results provided the first evidence that nattokinase can be measured directly in the blood of humans. The results further suggest that a larger, more extensive, pharmacokinetic study of nattokinase is warranted. Additionally, looking for intact enzyme and bioactive nattokinase peptides should …
Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation
The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers collagen and thrombin, and the ...
PDF | Nattokinase (NK) is a fibrinolytic enzyme produced by Bacillus subtilis. This enzyme comes from a traditional Japanese fermented food called... | Find, read and cite all the research you need on ResearchGate
Nutritional Supplements for Healthy Aging: A Critical Analysis Review
Background: Healthy aging is defined as survival to advanced age while retaining autonomy in activities of daily living, high societal participation, and good quality of life. Sarcopenia, insomnia, cognitive impairment, and changes in sensation can ...
PDF | Background Taurine has become a popular supplement among athletes attempting to improve performance. While the effectiveness of taurine as an... | Find, read and cite all the research you need on ResearchGate
Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman ...
Exploring Taurine's Potential in Alzheimer’s Treatment: A Comprehensive Review
Alzheimer’s disease (AD) stands as one of the predominant neurodegenerative disorders, often culminating in dementia. Taurine, an endogenous amino acid, holds pivotal regulatory functions within the physiological milieu. Emerging evidence suggests ...
A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage
Glycine and cysteine are non-essential amino acids that are required to generate glutathione, an intracellular tripeptide that neutralizes reactive oxygen species and prevents tissue damage. During aging glutathione demand is thought to increase, ...
Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammation, endothelial ...
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that ...
Systematic Review for Protein and Creatine Supplements in Peri-operative Period in Elective Musculoskeletal Surgery – Knee and Hip Replacement
Background: Nutrition is increasingly becoming a greater part of medicine and in particular surgery. Pertinent nutritional clinical goals involve reducing recovery times by supplementing patients with additional nutrients and to prepare them for elective surgery so that recovery can be optimised. To assist in achieving the aforementioned outcomes within musculoskeletal surgery, supplementation with creatine and protein/Essential Amino Acids (EAA) can be a useful addition to patient care.
Methods: A systematic review was performed using EMBASE, Scopus and Medline as search engines. This yielded 200 articles of which nine were included within the analysis.
Findings: Two articles investigated creatine supplementation in orthopaedic knee surgery whilst seven focused on protein supplementation. Both creatine studies investigated pre and post-operative supplementation and found that creatine did not augment recovery of muscular strength. Whilst the six of the protein supplementation studies reported positive post-operative effects in respect to increases in strength and muscle mass. However no study matching the search criteria investigated the combination of both creatine and protein, likewise no study was found to report the speed of post-operative recovery with supplementation.
Conclusion: Supplementation with protein/EAA’s is beneficial for those in the post-operative period in helping to reduce muscle atrophy and improve wound healing. There is limited evidence regarding the effects of creatine supplementation within such clinical populations, however there is a very good safety profile for both protein/EAA and creatine highlighting that supplementation is safe and can be experimented with.
Keywords
Protein • Creatine • Supplements • Knee • Hip • Elective musculoskeletal surgery • Enhanced recovery • Orthopaedic surgery • Recovery
The Application of Creatine Supplementation in Medical Rehabilitation
Numerous health conditions affecting the musculoskeletal, cardiopulmonary, and nervous systems can result in physical dysfunction, impaired performance, muscle weakness, and disuse-induced atrophy. Due to its well-documented anabolic potential, ...
Revisiting luteolin: An updated review on its anticancer potential
Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a natural flavone, p…