Health

Ob Krebs durch eine labile Psyche entstehen kann oder positive Gedanken bei der Heilung helfen, erklärt die Ärztin Marisa Kurz in »Krebs verstehen«

I never would have guessed this was the solution to my ME/CFS. Jeff, on Phoenix Rising Jeff had a typical ME/CFS onset: he was a young, healthy and active individual before being felled by a viral infection and a high temperature. The infection left him with headaches, dizziness, muscle weakness […]

Chronic pain associated with fibromyalgia (FM) affects a large portion of the population but the underlying mechanisms leading to this altered pain are still poorly understood. Evidence suggests that FM involves altered neural processes in the central nervous system and neuroimaging methods such as …

Objectives  To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect. Design  Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials. Data sources  Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015. Eligibility criteria for study selection  Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome. Results  25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity

Sean Gibbons at the Institute for Systems Biology in Seattle, US, and co-workers will use their Global Grant for Gut Health to explore the unique gut microbial signatures, associated blood metabolites, and gene expression patterns in healthy elderly people.

The number of respiratory syncytial virus (RSV) cases have jumped close to 10 times higher in some states across Australia when compared to last year. Experts say COVID complacency and higher testing rates could be why.

Oral steroid usage is an important risk factor for AAA expansion, independent of other risk factors of atherosclerosis and MAD.

Background: Individuals with prevalent diabetes were reported to have higher risk of dementia and lower cognitive function. However, the trends of cognitive function before diabetes and in the years following diabetes onset remain unclear. Methods and Findings: This study included 12422 participants aged ≥45 years without baseline diabetes from the China Health and Retirement Longitudinal Study (CHARLS). Cognitive function was assessed at baseline (Wave 1, 2011), and at least one time from Wave 2 (2013) to Wave 4 (2018). During the 7-year follow-up, 1207 (9.7%, mean age 59.1 years, 39.9% males) participants developed new-onset diabetes. The cognitive function of both the without-diabetes group and the diabetes group declined annually during the follow-up. The annual decline rate of the diabetes group before diabetes onset was similar to that of the without-diabetes group during the follow-up. After diabetes onset, participants experienced accelerated rates of cognitive decline in global cognition (-0.023 SD/year; 95% CI, -0.043 to -0.004) and visuospatial abilities (-0.036 SD/year; -0.061 to -0.011), but not in orientation abilities (0.001 SD/year; -0.018 to 0.020). We also observed a tendency that episodic memory (-0.018 SD/year; -0.041 to 0.004) and attention and calculation abilities (-0.017 SD/year; -0.037 to 0.003) declined faster after new-onset diabetes, although the results did not meet our threshold of significance. In subgroup analysis, compared with those who developed diabetes between 45-54 years old, those developing diabetes older showed similar increments in cognitive decline rate after diabetes. Conclusions: Individuals experienced faster rate of cognitive decline after diabetes onset, but not during the pre-diabetes period. Age did not modify the effect of diabetes on future cognitive decline. Future studies are needed to learn the mechanisms of cognitive decline in a few years after new-onset diabetes. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported by the National Natural Science Foundation of China (Project No. 82202819, Qingmei Chen) and Boxi Natural Science Foundation (Project No. BXQN202118, Jing Shang). ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study used (or will use) ONLY openly available human data that were originally located at: http://charls.pku.edu.cn/zh-CN I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data used in this manuscript from the China Health and Retirement Longitudinal Study (CHARLS). We applied permission for the data access (http://charls.pku.edu.cn/zh-CN) and obtained access to use it. Prof. Yaohui Zhao (National School of Development of Peking University), John Strauss (University of Southern California), and Gonghuan Yang (Chinese Center for Disease Control and Prevention) are the principal investigators. Requests to access these data can also be directed to Jianian Hua (jnjnhua@foxmail.com).

Vitamin D has anti-proliferative, anti-inflammatory, and apoptotic abilities. Vitamin D deficiency can induce deoxyribonucleic acid (DNA) damage. The aim of the study was to create a systematic review to analyze the relationship between vitamin D and DNA damage in various populations. PubMed, Scopus …

How much vitamin D we take has a dose-dependent effect on changes in our genetic expression Vitamin D has a well-known role in calcium regulation and bone health. However, vitamin D deficiency can be linked to the increased risk of many diseases, from heart disease to cancer, multiple sclerosis, neurocognitive function, prenatal outcomes, and even […]

Background Maternal vitamin status preconception and during pregnancy have important consequences for pregnancy outcome and offspring development. Changes in status from preconception to early and late pregnancy and postpartum have been inferred from cross-sectional data, with lower pregnancy concentrations often ascribed to plasma volume expansion, but without truly longitudinal data from preconception through pregnancy and post-delivery, and sparse data on the influence of supplementation. This study characterized longitudinal patterns of maternal vitamin status from preconception, through early and late pregnancy, to 6-months post-delivery, and determined the influence of supplementation. Methods and Findings Between 2015-2017, 1729 UK, Singapore and New Zealand women aged 18-38 years planning conception were recruited from the community to a double-blind controlled trial and randomized to a standard (control) or an intervention supplement preconception and throughout pregnancy. Vitamins common to both supplements were folic acid and β-carotene, with the intervention additionally including riboflavin, vitamins B6, B12 and D in amounts available in over-the-counter supplements, alongside iron, calcium and iodine (control and intervention) and myo-inositol, probiotics and zinc (intervention only). We measured maternal plasma concentrations of B-vitamins, vitamin D and insufficiency/deficiency markers (homocysteine, hydroxykynurenine-ratio, methylmalonic acid), at recruitment and 1-month after commencing intervention preconception, in early and late pregnancy, and post-delivery (6-months after supplement discontinuation). From all timepoint data, we derived standard deviation scores (SDS) to characterize longitudinal changes in controls and differences between control and intervention participants. At recruitment preconception, significant proportions had marginal or low plasma status for folate (29.2%

A new study finds a link between low vitamin D levels and all-cause mortality - including CVD and cancer. Researchers say the deficiency may even be linked to cancer prognosis.

For nearly a century, researchers have associated periodontal disease (PD) with risks of other adverse health outcomes such as cardiovascular disease, diabetes mellitus, and respiratory diseases, as well as adverse pregnancy outcomes. Those findings have led to the hypothesis that PD causes those adverse health outcomes either by increasing systemic inflammation or by the action of periodontopathic bacteria. However, experiments largely failed to support that hypothesis. Instead, the association is casual, not causal, and is due to shared underlying modifiable risk factors, including smoking, diet, obesity, low levels of physical activity, and low vitamin D status. Diabetes mellitus is also considered a risk factor for PD, whereas red and processed meat are the most important dietary risk factors for diabetes. Because PD generally develops before other adverse health outcomes, a diagnosis of PD can alert patients that they could reduce the risk of adverse health outcomes with lifestyle changes. In addition, type 2 diabetes mellitus can often be reversed rapidly by adopting an anti-inflammatory, nonhyperinsulinemic diet that emphasizes healthful, whole plant-based foods. This review describes the evidence that proinflammatory and prohyperinsulinemia diets and low vitamin D status are important risk factors for PD and other adverse health outcomes. We also make recommendations regarding dietary patterns, food groups, and serum 25-hydroxyvitamin D concentrations. Oral health professionals should routinely inform patients with PD that they could reduce their risk of severe PD as well as the risks of many other adverse health outcomes by making appropriate lifestyle changes.

Entzündete Schleimbeutel sind häufig überlastet. Starker Druck von außen und hohe Spannungen im Gewebe können ihnen schaden. Mit diesen Übungen sorgst du für Entlastung und unterstützt die Heilung.

Alles, was ihr schon immer übers Schlafen wissen wolltet: Wie viel braucht ihr, warum ist es wichtig, wie funktioniert es, warum hat es die Natur erfunden?

Many people are concerned about whether they are getting “enough” sleep, and if they can “sleep too much.” These concerns can be approached scientifically using experiments probing long-term (i.e., multi-night) sleep homeostatic processes, since homeostatic processes move the system toward its physiological setpoint (i.e., between “not enough” and “too much”). We analyzed sleep data from two human studies with sleep opportunities much longer than people usually stay in bed (i.e., conditions in which sleep homeostatic responses could be documented): sleep opportunities were 14–16 h per day for 3–28 days. Across the nights of the extended sleep opportunities, total sleep duration, Rapid Eye Movement (REM) sleep duration and non-REM sleep durations decreased and sleep latency increased. Multiple nights were required to reach approximately steady-state values. These results suggest a multi-day homeostatic sleep process responding to self-selected insufficient sleep duration prior to the study. Once steady state-values were reached, there were large night-to-night variations in total sleep time and other sleep metrics. Our results therefore answer these concerns about sleep amount and are important for understanding the basic physiology of sleep and for two sleep-related topics: (i) the inter-individual and intra-individual variability are relevant to understanding “normal” sleep patterns and for people with insomnia and (ii) the multiple nights of sleep required for recovery f...

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood. During this process, the areas of the brain that control smell and long-term memory ...

Regardless of the muscle they had, high levels of fat mass in an individual were associated with poorer overall health.

Das Entscheidende bei der Kalorienreduktion sind anscheinend gar nicht die Kalorien

Objective To investigate the potential causal effects of long term plasma caffeine concentrations on adiposity, type 2 diabetes, and major cardiovascular diseases. Design Two sample mendelian randomisation study. Setting Genome-wide association study summary data for associations of two single nucleotide polymorphisms associated with plasma caffeine at the genome-wide significance threshold (rs2472297 near the CYP1A2 gene and rs4410790 near the AHR gene) and their association with the outcomes. Participants Primarily individuals of European ancestry participating in cohorts contributing to genome-wide association study consortia. Main outcome measures Outcomes studied were body mass index, whole body fat mass, whole body fat-free mass, type 2 diabetes, ischaemic heart disease, atrial fibrillation, heart failure, and stroke. Results Higher genetically predicted plasma caffeine concentrations were associated with lower body mass index (beta −0.08 standard deviation (SD) (95% confidence interval −0.10 to −0.06), where 1 SD equals about 4.8 kg/m2 in body mass index, for every standard deviation increase in plasma caffeine) and whole body fat mass (beta −0.06 SD (−0.08 to −0.04), 1 SD equals about 9.5 kg; P

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans. However, in recent years ...

There appears to be a previously unrecognized immune evasion mechanism with IgG4 playing an essential role in cancer microenvironment with implications in cancer diagnosis and immunotherapy.

Kennt ihr diese ability/severity-Skala für #MEcfs? Ich finde mich da deutlich besser wieder als in der Bell-Skala. Sie unterscheidet zwischen physischen & kognitiven Fähigkeiten + Symptomschwere. Schlechte Referenzen haben dazu geführt, dass ich mich lange selbst gaslightete. https://t.co/HcGc7KL10A pic.twitter.com/Rqlx0ixlzV— Mirja (@mirvielleicht) March 10, 2023

The most comprehensive survey of how we share our microbiomes suggests a new way of thinking about the risks of developing some diseases that aren’t usually considered contagious.

Seasonal influenza virus infections cause mild illness in healthy adults, as timely viral clearance is mediated by the functions of cytotoxic T cells. However, avian H5N1 influenza virus infections can result in prolonged and fatal illness across all age groups, which has been attributed to the overt and uncontrolled activation of host immune responses. Here, we investigate how excessive innate immune responses to H5N1 impair subsequent adaptive T cell responses in the lungs. Using recombinant H1N1 and H5N1 strains sharing 6 internal genes, we demonstrate that H5N1 (2:6) infection in mice causes higher stimulation and increased migration of lung dendritic cells to the draining lymph nodes, resulting in greater numbers of virus-specific T cells in the lungs. Despite robust T cell responses in the lungs, H5N1 (2:6)-infected mice showed inefficient and delayed viral clearance compared with H1N1-infected mice. In addition, we observed higher levels of inhibitory signals, including increased PD-1 and interleukin-10 (IL-10) expression by cytotoxic T cells in H5N1 (2:6)-infected mice, suggesting that delayed viral clearance of H5N1 (2:6) was due to the suppression of T cell functions in vivo. Importantly, H5N1 (2:6)-infected mice displayed decreased numbers of tissue-resident memory T cells compared with H1N1-infected mice; however, despite the decreased number of tissue-resident memory T cells, H5N1 (2:6) was protected against a heterologous challenge from H3N2 virus (X31). Taken together, our study provides mechanistic insight for the prolonged viral replication and protracted illness observed in H5N1-infected patients.

Despite dramatic improvements in survival, nutrition, and education over recent decades, today's children face an uncertain future. Climate change, ecological degradation, migrating populations, conflict, pervasive inequalities, and predatory commercial practices threaten the health and future of children in every country. In 2015, the world's countries agreed on the Sustainable Development Goals (SDGs), yet nearly 5 years later, few countries have recorded much progress towards achieving them. This Commission presents the case for placing children, aged 0–18 years, at the centre of the SDGs: at the heart of the concept of sustainability and our shared human endeavour.

Schrankenlose Übertragung: Eine globale Kartierung von Antibiotika-Resistenzen enthüllt ein unerwartetes Muster der Ausbreitung. Demnach werden die