Health

A new study finds a link between low vitamin D levels and all-cause mortality - including CVD and cancer. Researchers say the deficiency may even be linked to cancer prognosis.

For nearly a century, researchers have associated periodontal disease (PD) with risks of other adverse health outcomes such as cardiovascular disease, diabetes mellitus, and respiratory diseases, as well as adverse pregnancy outcomes. Those findings have led to the hypothesis that PD causes those adverse health outcomes either by increasing systemic inflammation or by the action of periodontopathic bacteria. However, experiments largely failed to support that hypothesis. Instead, the association is casual, not causal, and is due to shared underlying modifiable risk factors, including smoking, diet, obesity, low levels of physical activity, and low vitamin D status. Diabetes mellitus is also considered a risk factor for PD, whereas red and processed meat are the most important dietary risk factors for diabetes. Because PD generally develops before other adverse health outcomes, a diagnosis of PD can alert patients that they could reduce the risk of adverse health outcomes with lifestyle changes. In addition, type 2 diabetes mellitus can often be reversed rapidly by adopting an anti-inflammatory, nonhyperinsulinemic diet that emphasizes healthful, whole plant-based foods. This review describes the evidence that proinflammatory and prohyperinsulinemia diets and low vitamin D status are important risk factors for PD and other adverse health outcomes. We also make recommendations regarding dietary patterns, food groups, and serum 25-hydroxyvitamin D concentrations. Oral health professionals should routinely inform patients with PD that they could reduce their risk of severe PD as well as the risks of many other adverse health outcomes by making appropriate lifestyle changes.

Entzündete Schleimbeutel sind häufig überlastet. Starker Druck von außen und hohe Spannungen im Gewebe können ihnen schaden. Mit diesen Übungen sorgst du für Entlastung und unterstützt die Heilung.

Alles, was ihr schon immer übers Schlafen wissen wolltet: Wie viel braucht ihr, warum ist es wichtig, wie funktioniert es, warum hat es die Natur erfunden?

Many people are concerned about whether they are getting “enough” sleep, and if they can “sleep too much.” These concerns can be approached scientifically using experiments probing long-term (i.e., multi-night) sleep homeostatic processes, since homeostatic processes move the system toward its physiological setpoint (i.e., between “not enough” and “too much”). We analyzed sleep data from two human studies with sleep opportunities much longer than people usually stay in bed (i.e., conditions in which sleep homeostatic responses could be documented): sleep opportunities were 14–16 h per day for 3–28 days. Across the nights of the extended sleep opportunities, total sleep duration, Rapid Eye Movement (REM) sleep duration and non-REM sleep durations decreased and sleep latency increased. Multiple nights were required to reach approximately steady-state values. These results suggest a multi-day homeostatic sleep process responding to self-selected insufficient sleep duration prior to the study. Once steady state-values were reached, there were large night-to-night variations in total sleep time and other sleep metrics. Our results therefore answer these concerns about sleep amount and are important for understanding the basic physiology of sleep and for two sleep-related topics: (i) the inter-individual and intra-individual variability are relevant to understanding “normal” sleep patterns and for people with insomnia and (ii) the multiple nights of sleep required for recovery f...

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood. During this process, the areas of the brain that control smell and long-term memory ...

Regardless of the muscle they had, high levels of fat mass in an individual were associated with poorer overall health.

Das Entscheidende bei der Kalorienreduktion sind anscheinend gar nicht die Kalorien

Objective To investigate the potential causal effects of long term plasma caffeine concentrations on adiposity, type 2 diabetes, and major cardiovascular diseases. Design Two sample mendelian randomisation study. Setting Genome-wide association study summary data for associations of two single nucleotide polymorphisms associated with plasma caffeine at the genome-wide significance threshold (rs2472297 near the CYP1A2 gene and rs4410790 near the AHR gene) and their association with the outcomes. Participants Primarily individuals of European ancestry participating in cohorts contributing to genome-wide association study consortia. Main outcome measures Outcomes studied were body mass index, whole body fat mass, whole body fat-free mass, type 2 diabetes, ischaemic heart disease, atrial fibrillation, heart failure, and stroke. Results Higher genetically predicted plasma caffeine concentrations were associated with lower body mass index (beta −0.08 standard deviation (SD) (95% confidence interval −0.10 to −0.06), where 1 SD equals about 4.8 kg/m2 in body mass index, for every standard deviation increase in plasma caffeine) and whole body fat mass (beta −0.06 SD (−0.08 to −0.04), 1 SD equals about 9.5 kg; P

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans. However, in recent years ...

There appears to be a previously unrecognized immune evasion mechanism with IgG4 playing an essential role in cancer microenvironment with implications in cancer diagnosis and immunotherapy.

Kennt ihr diese ability/severity-Skala für #MEcfs? Ich finde mich da deutlich besser wieder als in der Bell-Skala. Sie unterscheidet zwischen physischen & kognitiven Fähigkeiten + Symptomschwere. Schlechte Referenzen haben dazu geführt, dass ich mich lange selbst gaslightete. https://t.co/HcGc7KL10A pic.twitter.com/Rqlx0ixlzV— Mirja (@mirvielleicht) March 10, 2023

The most comprehensive survey of how we share our microbiomes suggests a new way of thinking about the risks of developing some diseases that aren’t usually considered contagious.

Seasonal influenza virus infections cause mild illness in healthy adults, as timely viral clearance is mediated by the functions of cytotoxic T cells. However, avian H5N1 influenza virus infections can result in prolonged and fatal illness across all age groups, which has been attributed to the overt and uncontrolled activation of host immune responses. Here, we investigate how excessive innate immune responses to H5N1 impair subsequent adaptive T cell responses in the lungs. Using recombinant H1N1 and H5N1 strains sharing 6 internal genes, we demonstrate that H5N1 (2:6) infection in mice causes higher stimulation and increased migration of lung dendritic cells to the draining lymph nodes, resulting in greater numbers of virus-specific T cells in the lungs. Despite robust T cell responses in the lungs, H5N1 (2:6)-infected mice showed inefficient and delayed viral clearance compared with H1N1-infected mice. In addition, we observed higher levels of inhibitory signals, including increased PD-1 and interleukin-10 (IL-10) expression by cytotoxic T cells in H5N1 (2:6)-infected mice, suggesting that delayed viral clearance of H5N1 (2:6) was due to the suppression of T cell functions in vivo. Importantly, H5N1 (2:6)-infected mice displayed decreased numbers of tissue-resident memory T cells compared with H1N1-infected mice; however, despite the decreased number of tissue-resident memory T cells, H5N1 (2:6) was protected against a heterologous challenge from H3N2 virus (X31). Taken together, our study provides mechanistic insight for the prolonged viral replication and protracted illness observed in H5N1-infected patients.

Despite dramatic improvements in survival, nutrition, and education over recent decades, today's children face an uncertain future. Climate change, ecological degradation, migrating populations, conflict, pervasive inequalities, and predatory commercial practices threaten the health and future of children in every country. In 2015, the world's countries agreed on the Sustainable Development Goals (SDGs), yet nearly 5 years later, few countries have recorded much progress towards achieving them. This Commission presents the case for placing children, aged 0–18 years, at the centre of the SDGs: at the heart of the concept of sustainability and our shared human endeavour.

Schrankenlose Übertragung: Eine globale Kartierung von Antibiotika-Resistenzen enthüllt ein unerwartetes Muster der Ausbreitung. Demnach werden die

Erfahre alles über antientzündliche Ernährung und welche Lebensmittel dafür gut geeignet sind. Deine pronova BKK informiert.

Is a diet comprised solely of meat good for you? I think you know the answer.

The pathomechanisms behind NSAID-exacerbated respiratory disease are complex and still largely unknown. They are presumed to involve genetic predisposition and environmental triggers that lead to dysregulation of fatty acid and lipid metabolism, altered cellular interactions involving transmetabolism, and continuous and chronic inflammation in the respiratory track. Here, we go through the recent advances on the topic and sum up the current understanding of the background of this illness that broadly effects the patients' lives.

In einer wenig erforschten Hirnregion fanden Wissenschaftler Nervenzellen, die das Stresshormon CRH produzieren. Es scheint mitunter bei Vermeidungsverhalten eine Rolle zu spielen. Das könnte für das Verständnis psychiatrischer Erkrankungen wichtig sein.

Adding to previous research on the gut-brain axis link to Parkinson's disease, researchers discovered the gut microbiome is involved with multiple pathways in the pathogenesis of Parkinson's.

Noncommunicable diseases (NCDs), also known as chronic diseases, kill 40 million people each year.

Gib hier die Lufttemperatur ein und C° die Relative Feuchte%

Nature - Examination of archaeological pottery residues and modern genes suggest that environmental conditions, subsistence economics and pathogen exposure may explain selection for lactase...

Die Arbeit befasst sich mit der Entwick- lung der Viruzidietestung insbesondere in Deutschland. Die gegenwärtig zur Ver- fügung stehenden Prüfmethoden in Form von Suspension- bzw. praxisnahen Tests werden vorgestellt und erläutert. Basierend auf Prüfungen mit diesen Tests existieren verschiedene Listen bzw. Zusammenstel- lungen zur Viruswirksamkeit von Desinfek- tionsmitteln, deren jeweilige Besonderhei- ten beschrieben werden.

Melatonin is associated with a variety of diseases in advanced age, including insomnia, depression, and dementia, and its secretion is influenced by light exposure. Although studies in young and middle-aged subjects have shown that females tend to have ...

Saarbrücker Forscher optimieren Wirkstoffkandidaten gegen multiresistente Bakterien und Parasiten. Im Fokus steht dabei die Naturstoffklasse der Chlorotonile.