Health

Kurkuma ist eine erstaunliche Pflanzenart mit einem weiten Spektrum für gesundheitliche Vorteile. Ein Beitrag von mir zählt das breit gefächerte Spektrum von Wirksamkeiten von Kurkuma auf:

Fatty liver supplements can be effective in helping you heal—but take these important lifestyle steps first.

Scientific Reports - A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles

These results provided the first evidence that nattokinase can be measured directly in the blood of humans. The results further suggest that a larger, more extensive, pharmacokinetic study of nattokinase is warranted. Additionally, looking for intact enzyme and bioactive nattokinase peptides should …

The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers collagen and thrombin, and the ...

PDF | Nattokinase (NK) is a fibrinolytic enzyme produced by Bacillus subtilis. This enzyme comes from a traditional Japanese fermented food called... | Find, read and cite all the research you need on ResearchGate

Background: Healthy aging is defined as survival to advanced age while retaining autonomy in activities of daily living, high societal participation, and good quality of life. Sarcopenia, insomnia, cognitive impairment, and changes in sensation can ...

PDF | Background Taurine has become a popular supplement among athletes attempting to improve performance. While the effectiveness of taurine as an... | Find, read and cite all the research you need on ResearchGate

Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman ...

Scientific Reports - Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging

Alzheimer’s disease (AD) stands as one of the predominant neurodegenerative disorders, often culminating in dementia. Taurine, an endogenous amino acid, holds pivotal regulatory functions within the physiological milieu. Emerging evidence suggests ...

Glycine and cysteine are non-essential amino acids that are required to generate glutathione, an intracellular tripeptide that neutralizes reactive oxygen species and prevents tissue damage. During aging glutathione demand is thought to increase, ...

Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammation, endothelial ...

Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that ...

Background: Nutrition is increasingly becoming a greater part of medicine and in particular surgery. Pertinent nutritional clinical goals involve reducing recovery times by supplementing patients with additional nutrients and to prepare them for elective surgery so that recovery can be optimised. To assist in achieving the aforementioned outcomes within musculoskeletal surgery, supplementation with creatine and protein/Essential Amino Acids (EAA) can be a useful addition to patient care. Methods: A systematic review was performed using EMBASE, Scopus and Medline as search engines. This yielded 200 articles of which nine were included within the analysis. Findings: Two articles investigated creatine supplementation in orthopaedic knee surgery whilst seven focused on protein supplementation. Both creatine studies investigated pre and post-operative supplementation and found that creatine did not augment recovery of muscular strength. Whilst the six of the protein supplementation studies reported positive post-operative effects in respect to increases in strength and muscle mass. However no study matching the search criteria investigated the combination of both creatine and protein, likewise no study was found to report the speed of post-operative recovery with supplementation. Conclusion: Supplementation with protein/EAA’s is beneficial for those in the post-operative period in helping to reduce muscle atrophy and improve wound healing. There is limited evidence regarding the effects of creatine supplementation within such clinical populations, however there is a very good safety profile for both protein/EAA and creatine highlighting that supplementation is safe and can be experimented with. Keywords Protein • Creatine • Supplements • Knee • Hip • Elective musculoskeletal surgery • Enhanced recovery • Orthopaedic surgery • Recovery

Numerous health conditions affecting the musculoskeletal, cardiopulmonary, and nervous systems can result in physical dysfunction, impaired performance, muscle weakness, and disuse-induced atrophy. Due to its well-documented anabolic potential, ...

Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a natural flavone, p…

Objectives To assess the role of ultrasensitive PSA values (usPSA) after radical prostatectomy in predicting the subsequent biochemical recurrence (BCR). Material and methods The study included 18...

AbstractThe diagnosis of appendicitis may be difficult to establish even for the experienced surgeon. Considerable variability in presenting symptoms and signs, resulting in part from the numerous locations in which the appendix may be found, contributes ...

Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor ...

Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. Objective To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. Design and Setting The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. Participants A total of 16,616 men and nonpregnant women aged 17 years or older. Main Outcome Measures Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. Results Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, ≥30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI, 25 kg/m2). After adjustment for potential confounders, including smoking and health status, the odds ratio (OR) for elevated CRP was 2.13 (95% confidence interval [CI], 1.56-2.91) for obese men and 6.21 (95% CI, 4.94-7.81) for obese women. In addition, BMI was associated with clinically raised CRP levels in women, with an OR of 4.76 (95% CI, 3.42-6.61) for obese women. Waist-to-hip ratio was positively associated with both elevated and clinically raised CRP levels, independent of BMI. Restricting the analyses to young adults (aged 17-39 years) and excluding smokers, persons with inflammatory disease, cardiovascular disease, or diabetes mellitus and estrogen users did not change the main findings. Conclusion Higher BMI is associated with higher CRP concentrations, even among young adults aged 17 to 39 years. These findings suggest a state of low-grade systemic inflammation in overweight and obese persons.

The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials and the presence of causal a relationship between body mass index (BMI) and C-reactive protein (CRP) is ...

The current review provides an up-to-date analysis of scientific data on astaxanthin (ASX) sources and experimental studies on its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid nutrient and ...

There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Astaxanthin (3,3′-dihydroxy-β, ...

Astaxanthin is a unique carotenoid of predominantly marine origin providing the pink-red color to certain microalgae and accumulating in various animals higher in the food chain. It is an antioxidant without pro-oxidant properties or known side-effects following oral intake. Materials and Methods: We investigated astaxanthin kinetics in plasma and erythrocytes (red blood cells [RBC]) of four healthy adults after a single oral 40 mg dose. Plasma- and RBC-astaxanthin were measured during 72 h. Subsequently, an 8 mg/day dose was given during 17 days. Plasma- and RBC-astaxanthin were measured each morning. Results: Plasma-astaxanthin reached a peak (from 79 to 315 nmol/L) after 8 h and then declined (half-life, 18 h). Within 72 h, plasma-astaxanthin had returned to baseline. RBC-astaxanthin reached a peak (from 63 to 137 nmol/L packed cells) at 12 h and subsequently disappeared (half-life, 28 h). During the daily dose, plasma-astaxanthin increased until day 10 (187 nmol/L) and then decreased to a steady concentration similar to that reached after 2 days. RBC-astaxanthin appeared to be highly variable (group median concentration, 86 nmol/L packed cells). Conclusion: We found high intra- and inter-individual variations, especially in RBC, possibly due to non-standardized time difference between astaxanthin intake and sampling, fluctuating background intake from the diet, variable bioavailability, large distribution volume, degradation or others. Oral astaxanthin is rapidly absorbed and incorporated into RBC. The subsequent rapid decline suggests that, for a higher-than-baseline status, astaxanthin should be taken daily, at least in an early phase when total body equilibrium, if any, has not been reached yet. Key words: Absorption, antioxidant, carotenoid, half-life, humans, status

Appreciation of the importance of Akkermansia muciniphila is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via Akkermansia muciniphila. In ...

Welcome to the Probiotics Database, a hub for the leading research in probiotics.

Recent research has revealed the importance of the appendix in regulating the intestinal microbiota and mucosal immunity. However, the changes that occur in human gut microbial communities after appendectomy have never been analyzed. We assessed the ...