Health

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

Exploring a natural route to better health? Luteolin supplements are gaining traction as a promising alternative to traditional medicines.

Pain due to chronic conditions is a frequent and insufficiently addressed problem. Current drug options for pain management (either in cases of chronic inflammatory conditions or neuropathy) do not adequately treat pain. Moreover, they are ...

Dementia is a growing problem around the globe as the world's population continues to age. Multiple studies have identified potentially modifiable ris…

Like other organs, brain functions diminish with age. Furthermore, for a variety of neurological disorders—including Alzheimer’s disease—age is one of the higher-risk factors. Since in many Western countries the average age is increasing, ...

Fisetin, a natural plant compound, offers numerous benefits for individuals dealing with obesity and diabetes.

Stimmt es, dass die zusätzliche Einnahme von Arginin gut für die Durchblutung im Körper ist?

Utilising proteomic and transposon sequencing screens, Freiberg et al. identified arginine metabolism enzymes that impact tolerance to antibiotics in Staphylococcus aureus, including in animal models of skin and bone infections.

Raynaud's phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Severe Raynaud's phenomenon can cause digital necrosis. It has been hypothesized that nitric oxide may have a role in Raynaud's phenomenon. We report two cases in which oral …

Objective  To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD).Design  Prospective study of 639 individuals who underwent audiometric testing and were dementia free in 1990 to 1994. Hearing loss was defined by a pure-tone average of...

Some scientists believe that microbes might play a part in Alzheimer's disease development. There are several theories about how and why this occurs. Microbes that might be involved include certain...

Quercetin is the major polyphenolic flavonoid that belongs to the class called flavanols. It is found in many foods, such as green tea, cranberry, apple, onions, asparagus, radish leaves, buckwheat, blueberry, broccoli, and coriander. It occurs in ...

NAD+, a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age. In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38. In animal models, ...

Hyperuricemia, the high uric acid (UA) state in blood, has been accepted as an important risk factor for gout. The liver is a main factory of UA production. In the present study, we have examined the effects of three kinds of flavonol and flavones ...

In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS). Theaflavins (TFs) are a polyphenol hydroxyl substance with the structure of diphenol ketone, ...

Theaflavins (TFs) are orange-red pigments with a benzotropolone structure, which are formed by the polymerization of catechins under oxidase-catalysed…

Background: Theaflavins (TFs) are a category of natural compounds characterized with the benzotropolone skeleton. The prominent benefits of TFs have been well documented. Amount of research were conducted and excellent achievements were disclosed ...

Apigenin (4′, 5, 7-trihydroxyflavone) is a plant flavone that has been found to have various actions against cancer cells. We evaluated available evidence to determine whether it is feasible for apigenin to have such effects in human patients. ...

Apigenin is a flavonoid of low toxicity and multiple beneficial bioactivities. Published reviews all focused on the findings using eukaryotic cells, animal models, or epidemiological studies covering the pharmacokinetics, cancer chemoprevention, and ...

Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to ...

Flavonoids, being prevalent in fruits and vegetables, are essential to the diverse stages of plant growth, development, and storage. Furthermore, flavonoids have been shown to exert substantial beneficial effects on human health, prompting heightened scientific interest in their potential advantages. This review elucidates the functions of flavonoids in fruits and vegetables, confirming their position as natural sources of these compounds, despite the differences in type and concentration among various species. This review elucidates the significance of flavonoids in the growth and development of fruits and vegetables, highlighting their roles in enhancing pigmentation and providing protection against both biotic and abiotic stresses. In relation to human health, flavonoids are recognized for their ability to combat aging, mitigate inflammation, safeguard the nervous system, and promote overall well-being. Additionally, this review proposes avenues for future research in the domain of flavonoids, underscoring the necessity for ongoing exploration of their potential applications and benefits.

Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food ...

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including ...

Hyperuricemia, the high uric acid (UA) state in blood, has been accepted as an important risk factor for gout. The liver is a main factory of UA production. In the present study, we have examined the effects of three kinds of flavonol and flavones as typical aglycons, i.e., quercetin, luteolin, apig …

Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, ...

Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. We searched for relevant studies on ...

Im Alter ist Schwerhörigkeit normal - oder? Ist eine Hörminderung wirklich ein Risikofaktor, eine #Demenz zu entwickeln? Antworten hier.

Schwerhörigkeit im Alter gilt unter Experten als größter beeinflussbarer Risikofaktor für Demenz. Deshalb sollte der Hörverlust möglichst früh erkannt und mit einem Hörgerät behandelt werden.