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Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers
Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers
This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that ...
·pmc.ncbi.nlm.nih.gov·
Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers
L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression - PMC
L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression - PMC
The anti-stress potential of dietary L-arginine (Arg) was assessed in psychosocially stress-loaded senescence-accelerated (SAMP10) mice. Although this strain of mouse is sensitive to stress, daily administration of Arg at 3 mg/kg significantly ...
·pmc.ncbi.nlm.nih.gov·
L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression - PMC
Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
Chronic hyperglycemia induces oxidative stress via accumulation of reactive oxygen species (ROS) and contributes to diabetic complications. Hyperglycemia induces mitochondrial superoxide anion production through the increased activity of ...
·pmc.ncbi.nlm.nih.gov·
Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Scientific Reports - Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
·nature.com·
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives
Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives
Common flavonoid luteolin 3′,4′,5,7-tetrahydroxyflavone has immense potential to be utilized as a chemopreventive dietary molecule. According to available data, luteolin interacts with a number of known cellular targets and prevents the growth of ...
·pmc.ncbi.nlm.nih.gov·
Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives
Luteolin ameliorates hyperuricemic nephropathy by activating urate excretion and Nrf2/HO‐1/NQO1 antioxidant pathways in mice
Luteolin ameliorates hyperuricemic nephropathy by activating urate excretion and Nrf2/HO‐1/NQO1 antioxidant pathways in mice
Luteolin is a natural flavonoid, which exists in many plants, including onions, broccoli, carrots, peppers, celery, olive oil, and mint. Luteolin is a dietary flavonoid with potent uric acid‐lowering and antioxidant bioactivities. To date, the ...
·pmc.ncbi.nlm.nih.gov·
Luteolin ameliorates hyperuricemic nephropathy by activating urate excretion and Nrf2/HO‐1/NQO1 antioxidant pathways in mice
The bright and the dark sides of L-carnitine supplementation: a systematic review
The bright and the dark sides of L-carnitine supplementation: a systematic review
L-carnitine (LC) is used as a supplement by recreationally-active, competitive and highly trained athletes. This systematic review aims to evaluate the effect of prolonged LC supplementation on metabolism and metabolic modifications. A literature ...
·pmc.ncbi.nlm.nih.gov·
The bright and the dark sides of L-carnitine supplementation: a systematic review
The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition
The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition
Flavonoids are natural polyphenolic compounds with desired bio-functions but with chemical instability and sensitivity to temperature, oxygen, and other factors. Apigenin and luteolin, two flavones of the flavonoid family in plant foods, were; thus, ...
·pmc.ncbi.nlm.nih.gov·
The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition
Arginine Signaling and Cancer Metabolism
Arginine Signaling and Cancer Metabolism
Arginine is an amino acid critically involved in multiple cellular processes including the syntheses of nitric oxide and polyamines, and is a direct activator of mTOR, a nutrient-sensing kinase strongly implicated in carcinogenesis. Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells’ intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase). As such, arginine can be used as a dietary supplement and its depletion as a therapeutic strategy. Strikingly, in over 70% of tumors, ASS1 transcription is suppressed, rendering the cells addicted to external arginine, forming the basis of arginine-deprivation therapy. In this review, we will discuss arginine as a signaling metabolite, arginine’s role in cancer metabolism, arginine as an epigenetic regulator, arginine as an immunomodulator, and arginine as a therapeutic target. We will also provide a comprehensive summary of ADI (arginine deiminase)-based arginine-deprivation preclinical studies and an update of clinical trials for ADI and arginase. The different cell killing mechanisms associated with various cancer types will also be described.
·mdpi.com·
Arginine Signaling and Cancer Metabolism
Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression
Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression
Arginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells ...
·pmc.ncbi.nlm.nih.gov·
Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression
Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors
Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors
• Low plasma ARG levels are associated with a worse clinical benefit rate, progression-free survival, and overall survival. • Low plasma ARG levels are associated with increased PD-L1 expression in immune cell subsets from the myeloid lineage. • The tumor rejection rate is higher in mice with high plasma ARG levels.
·annalsofoncology.org·
Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors
Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review - Cancer Cell International
Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review - Cancer Cell International
Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginine has a versatile role in the body because it helps in cell division, wound healing, ammonia disposal, immune system, and hormone biosynthesis. It is noteworthy that l-arginine is the precursor for the biosynthesis of nitric oxide (NO) and polyamines. In the case of cancer cells, arginine de novo synthesis is not enough to compensate for their high nutritional needs, forcing them to rely on extracellular supply of arginine. In this review, we will go through the importance of arginine deprivation as a novel targeting therapy by discussing the different arginine deprivation agents and their mechanism of action. We will also focus on the factors that affect cell migration and on the influence of arginine on metastases through polyamine and NO.
·cancerci.biomedcentral.com·
Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review - Cancer Cell International
Adverse Effects of Supplemental l-Arginine in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
Adverse Effects of Supplemental l-Arginine in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.
·ahajournals.org·
Adverse Effects of Supplemental l-Arginine in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
Effects of L-arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation
Effects of L-arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation
Exercise-induced impairment of blood fluidity is considered to be associated with thrombosis development. However, the effects of L-arginine on blood fluidity after exercise remain unclear. We investigated the mechanisms of impaired blood fluidity ...
·pmc.ncbi.nlm.nih.gov·
Effects of L-arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation
l-Arginine and Thrombosis | Circulation
l-Arginine and Thrombosis | Circulation
eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.
·ahajournals.org·
l-Arginine and Thrombosis | Circulation
Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle
Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle
We reviewed lifestyle factors that influence serum uric acid levels and risk of gout flare, and how to improve their deleterious effects. Since obesity increases uric acid and weight gain increases gout risk, weight reduction by daily exercise and ...
·pmc.ncbi.nlm.nih.gov·
Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle
Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative ...
·pmc.ncbi.nlm.nih.gov·
Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial
The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial
Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory ...
·pmc.ncbi.nlm.nih.gov·
The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
Xanthine oxidoreductase (XOR) is a molybdenum-containing enzyme that under physiological conditions catalyzes the final two steps in purine catabolism, ultimately generating uric acid for excretion. Here we have investigated four naturally-occurring ...
·pmc.ncbi.nlm.nih.gov·
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation ...
·ncbi.nlm.nih.gov·
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing flavonoids have been widely used in traditional medicine for thousands of years. Flavonols present in our diet may prevent cancer initiation, promotion and progression ...
·ncbi.nlm.nih.gov·
Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review