Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent - European Journal of Medical Research
Fisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits a range of biological effects, such as suppressing cell growth, triggering programmed cell death, reducing the formation of new blood vessels, protecting against oxidative stress, and inhibiting cell migration. Moreover, fisetin has the ability to enhance the effectiveness of chemotherapy. The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, and Nrf2/HO-1. Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment. In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.
Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee - PubMed
Dimethyl sulphoxide and methylsulfonylmethane are two related nutritional supplements used for symptomatic relief of osteoarthritis (OA). We conducted a meta-analysis to evaluate their efficacy in reducing pain associated with OA. Randomized or quasi-randomized controlled trials (RCTs), identified b …
Fisetin Benefits: Dosages and How to Take It - The Nutrition Insider
The fisetin benefits we know about today (e.g., anti-aging) are from relatively recent research. We dive into said research, including dosing and more.
Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies
Fisetin, a natural flavonoid found in a variety of
edible and medical plants, has been suggested to inhibit the
proliferation of various tumor cells and to induce apoptosis.
However, the effects of fisetin on breast cancer have rarely
been reported and the underlying mechanism is still undefined.
The present study explored the anti‑cancer effects of fisetin on
mammary carcinoma cells and the underlying mechanisms.
Following treatment with fisetin, viability of 4T1, MCF‑7
and MDA‑MB‑231 cells were measured by MTT assay. The
inhibitory effects of fisetin on proliferation, migration and
invasion were evaluated in 4T1 cells using proliferation array,
wound‑healing assay, and HUV‑EC‑C‑cell barrier based on
electrical cell‑substrate impedance sensing platform. Cell
apoptosis was analyzed by flow cytometry, and western blot-
ting analysis was performed to identify target molecules. A
4T1 orthotopic mammary tumor model was used to assess the
fisetin‑inhibition on tumor growth in vivo. Test kits were used to
examine the liver and kidney function of tumor‑bearing mice.
The results suggest that fisetin suppressed the proliferation of
breast cancer cells, suppressed the metastasis and invasiveness
of 4T1 cells, and induced the apoptosis of 4T1 cells in vitro.
The potent anti‑cancer effect of fisetin was associated with
the regulation of the phosphatidylinositol‑3‑kinase/protein
kinase B/mammalian target of rapamycin pathway. In vivo
experiments demonstrated that fisetin suppressed the growth of
4T1 cell‑derived orthotopic breast tumors and enhanced tumor
cell apoptosis, and the evaluated alanine amino transferase and
aspartate amino transferase levels in serum of tumor‑bearing
mice suggested that fisetin may lead to side effects on liver
biochemical function. The present study confirms that fisetin
exerted an anti‑mammary carcinoma effect. However, in vivo
experiments also revealed that fisetin had low solubility
and low bioavailability. Further investigation is required to
determine the clinical value of fisetin.
Fisetin ist ein Flavonoid/Polyphenol/sekundärer Pflanzenstoff. Er ist ein gelber Naturfarbstoff, aber vor allem ist er ein natürlich vorkommendes Senolytikum: ein Molekül, das gezielt den Tod (Apoptose) seneszenter, also alter Zellen, auslösen kann.1 Dies kann sowohl altersbedingte Erkrankungen verzögern als auch die Lebensspanne erhöhen.2 Warum ist es gesund und „verjüngend“, seneszente Zellen zu beseitigen? Seneszente […]
Fisetin is a senotherapeutic that extends health and lifespan - PubMed
The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit. These characteristics suggest the feasibility to translation to human clinical studies. FUND: NIH grants P01 AG043376 (PDR, LJN), U19 AG05627 …
Fisetin: A Dietary Antioxidant for Health Promotion
Significance: Diet-derived antioxidants are now being increasingly investigated for their health-promoting effects, including their role in the chemoprevention of cancer. In general, botanical antioxidants have received much attention, as they can be ...
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium
Despite a short history since its first isolation, Akkermansia muciniphila has been extensively studied in relation to its effects on human metabolism. A recent human intervention study also demonstrated that the bacterium is safe to use for therapeutic ...
Erfahren Sie, wie Sie die Fettleber auf natürliche Weise durch Änderungen des Lebensstils und der Ernährung abbauen können. Tipps zu den richtigen Lebensmitteln
Cognitive Motor Dissociation in Disorders of Consciousness | NEJM
Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phen...
Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study
Objective: To examine whether allopurinol is associated with any alteration in mortality and hospitalisations in patients with chronic heart failure (CHF). This hypothesis is based on previous data that a high urate concentration is independently associated ...
Metagenomic gut microbiome analysis of Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance - BMC Microbiology
Background Although the pathology of multiple chemical sensitivity (MCS) is unknown, the central nervous system is reportedly involved. The gut microbiota is important in modifying central nervous system diseases. However, the relationship between the gut microbiota and MCS remains unclear. This study aimed to identify gut microbiota variations associated with MCS using shotgun metagenomic sequencing of fecal samples. Methods We prospectively recruited 30 consecutive Japanese female patients with MCS and analyzed their gut microbiomes using shotgun metagenomic sequencing. The data were compared with metagenomic data obtained from 24 age- and sex-matched Japanese healthy controls (HC). Results We observed no significant difference in alpha and beta diversity of the gut microbiota between the MCS patients and HC. Focusing on the important changes in the literatures, at the genus level, Streptococcus, Veillonella, and Akkermansia were significantly more abundant in MCS patients than in HC (p
How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives
The environment influences mental health, both detrimentally and beneficially. Current research has emphasized the individual psychosocial ‘microenvironment’. Less attention has been paid to ‘macro-environmental’ challenges including climate change, pollution, urbanicity and socioeconomic disparity. With the advent of large-scale big-data cohorts and an increasingly dense mapping of macroenvironmental parameters, we are now in a position to characterise the relation between macroenvironment, brain, and behaviour across different geographic and cultural locations globally. This review synthesises findings from recent epidemiological and neuroimaging studies, aiming to provide a comprehensive overview of the existing evidence between the macroenvironment and the structure and functions of the brain, with a particular emphasis on its implications for mental illness. We discuss putative underlying mechanisms and address the most common exposures of the macroenvironment. Finally, we identify critical areas for future research to enhance our understanding of the aetiology of mental illness and to inform effective interventions for healthier environments and mental health promotion. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported by the European Union-funded Horizon Europe project 'environMENTAL' (101057429); and the UK Research and Innovation (UKRI) under the UK government's Horizon Europe (10041392 and 10038599) to EP, SH, KS and GS; the European Union-funded FP6 Integrated Project 'IMAGEN' (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT- 2007-037286); European Research Council Horizon 2020-funded advanced grant 'STRATIFY' (695313); the Medical Research Council Grant 'c-VEDA' (MR/N000390/1); the the Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539); the National Institutes of Health (529 R01DA049238); the German Research Foundation (675346); the National Natural Science Foundation of China (82202093); and the Chinese National High-end Foreign Expert Recruitment Plan and the Alexander von Humboldt Foundation to GS; the Shanghai International Science and Technology Partnership Project (21230780200); and the National Natural Science Foundation of China (42175066) to JY. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Details of the search process and included studies can be found in the manuscript. * ACC : anterior Cingulate Cortex ALAN : Artificial Light At Night CO : Carbon Monoxide dlPFC : dorsolateral Prefrontal Cortex DMN : Default Mode Network FC : Functional Connectivity GM : Gray Matter HPA : Hypothalamic-Pituitary-Adrenal IFG : Inferior Frontal Gyrus ipRGCs : intrinsically photosensitive Retinal Ganglion Cells mPFC : medial Prefrontal Cortex MRI : Magnetic Resonance Imaging NAc : Nucleus Accumbens NO2 : Nitrogen Dioxide NOx : Nitrogen Oxides PAH : Polycyclic Aromatic Hydrocarbons PFC : Prefrontal Cortex PM : Particulate Matter PM10 : Particulate Matter with aerodynamic diameter ≤ 10 μm PM2.5 : Particulate Matter with aerodynamic diameter ≤ 2.5 μm SO2 : Sulphur Dioxide TRAP : Traffic-Related Air Pollution WH : White Matter
Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations
The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevan…
Rheumatologists Find Nailfold Capillaroscopy an Increasingly Useful Diagnostic Tool - The Rheumatologist
Different tools for nailfold capillaroscopic analysis. Interest in viewing the nail capillaries dates to the late 17th century. Later research by Maurice Raynaud and others in the late 19th and early 20th century first established a direct link between the nailfold capillaries and certain medical conditions. Although underutilized in the past, with the advent of...
Der Zusammenhang zwischen Demenz und Bluthochdruck ist seit Jahren bekannt. Aber kann eine medikamentöse Behandlung der arteriellen Hypertonie wirklich das Demenz-Risiko senken? Hier gibt’s die aktuellen Infos.
