Covid

Booster doses of Pfizer and Moderna's COVID-19 vaccine will be offered late next month, beginning with those vaccinated first, like health care providers.

Shielding children from danger is a fundamental instinct. Tolerating risk for them is hard—but necessary—emotional work.

Georgia’s Cobb County School District had parents choose between virtual and in-person learning, then lifted its mask mandate. Many families are frantically figuring out how to navigate this reality. ProPublica reporter Nicole Carr is one of them.

Cases of COVID-19 are rising fast. Vaccine uptake has plateaued. The pandemic will be over one day—but the way there is different now.

One hundred people who had been fully vaccinated against the coronavirus died from the disease in Massachusetts by the end of July, according to the state Department of Public Health.

When his friends started to get sick after a week of parties, Michael Donnelly started keeping track. His work — and his community's willingness to help — led the CDC to a major pandemic discovery.

AbstractBackground. Multiple SARS-CoV-2 superspreading events suggest that aerosols play an important role in driving the COVID-19 pandemic. To better understan

As the Delta variant of the coronavirus fuels an ongoing COVID wave, San Francisco Bay Area health experts are keeping a close eye on yet another variant: Delta Plus.

The CDC’s recent announcement that the Delta variant has an average reproductive number of 6–9 has a lot of people concerned & many are…

Moderna says its COVID-19 vaccine is 93-percent effective against the coronavirus six months after patients get the second dose.

You’ve asked me to write a response to my student evaluations. I’m sitting in my living room, my feet are cold because I haven’t been wearing shoes. Who wears shoes to work at home? My dog runs into the room and then looks at me and runs out. “If you pee on the carpet one more time, I swear to god!” I yell in his direction. My students have heard me yell the same thing at him during class. “The quiz on this section will be an asynchronous OH MY GOD YOU DID NOT JUST DO THAT TO MY CARPET AGAIN ess

Why the variant’s spread may be less pervasive than we currently expect.

This week, you’re likely to encounter a lot of commentary on PRRI and Interfaith Youth Core’s new report on religious groups and vaccine acceptance, most of it optimistic. And to be sure, there are good reasons for optimism relative to the majority of faith communities in the United States, where in

Objectives Highly effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed but variants of concerns (VOCs) with mutations in the spike protein are worrisome, especially B.1.617.2 (Delta) which has rapidly spread across the world. We aim to study if vaccination alters virological and serological kinetics in breakthrough infections. Methods We conducted a multi-centre retrospective cohort study of patients in Singapore who had received a licensed mRNA vaccine and been admitted to hospital with B.1.617.2 SARS-CoV-2 infection. We compared the clinical features, virological and serological kinetics (anti-nucleocapsid, anti-spike and surrogate virus neutralization titres) between fully vaccinated and unvaccinated individuals. Results Of 218 individuals with B.1.617.2 infection, 84 had received a mRNA vaccine of which 71 were fully vaccinated, 130 were unvaccinated and 4 received a non-mRNA. Despite significantly older age in the vaccine breakthrough group, the odds of severe COVID-19 requiring oxygen supplementation was significantly lower following vaccination (adjusted odds ratio 0.07 95%CI: 0.015-0.335, p=0.001). PCR cycle threshold (Ct) values were similar between both vaccinated and unvaccinated groups at diagnosis, but viral loads decreased faster in vaccinated individuals. Early, robust boosting of anti-spike protein antibodies was observed in vaccinated patients, however, these titers were significantly lower against B.1.617.2 as compared with the wildtype vaccine strain. Conclusion The mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection. Vaccination is associated with faster decline in viral RNA load and a robust serological response. Vaccination remains a key strategy for control of COVID-19 pandemic. ### Competing Interest Statement BEY reports personal fees from Roche and Sanofi, outside the submitted work. All other authors declare no competing interests. ### Funding Statement This study was funded by grants from the Singapore National Medical Research Council (COVID19RF-001, COVID19RF-008). The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Written informed consent was obtained from study participants of the multi-centre study approved by National Healthcare Group Domain Specific Review Board (NHG-DSRB) (Study Reference 2012/00917). Informed consent for retrospective data collection at National Centre for Infectious Diseases (NCID) was waived (NHG-DSRB reference number 2020/01122). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

A third dose of the Pfizer/BioNTech Covid-19 vaccine can "strongly" boost protection against the Delta variant -- beyond the protection afforded by the standard two doses, suggests new data released by Pfizer on Wednesday.

The document captures the struggle of the nation’s top public health agency to persuade the public to embrace vaccination and prevention measures, including mask-wearing, as cases surge across the United States and new research suggests vaccinated people can spread the virus.

CNN’s Aya Elamroussi reports on people in Missouri who have gotten the covid vaccine secretly because they fear their friends and families will ostracize them. To get vaccinated against the k…

The CDC's eviction moratorium expires on July 31, and an extension is unlikely, leaving renters uncertain about their future in an economy still recovering from COVID.

The decline, from a peak of 96% efficacy, could fuel Pfizer’s case that a third dose will eventually be required.

The undocumented migrant family at Whataburger told a police officer that Border Patrol had released them because they had COVID-19.

A new analysis finds several counties with above-average vaccination rates also have higher COVID case rates, while case rates are falling in counties with below-average vaccination rates.

The rate of weekly Covid-19 case acceleration is a reasonable indicator of how intense that wave might be and how long it might last.

We offer advice about how to think about the cases.

The total number of COVID-19 cases in an ongoing Provincetown cluster has increased to 430, with 342 coming from Mass. residents.

Our vaccines are extraordinary, but right now they need all the help they can get.

The United States Update

They’re not all anti-vaxxers, and treating them as such is making things worse.

That’s a question that’s on a lot of people’s minds, because frankly, we have answers that seem to disagree with each other. Let’s have a look: For one, there’s this letter in the NEJM from researchers at Beth Israel Deaconess hospital and from Janssen (J&J’s pharma branch). That’s a look at immunity in 20 patients

The rate of fully vaccinated people ending up in the hospital remains low.