Covid

Covid

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Monkeypox 101, unanswered questions, and the bigger picture
Monkeypox 101, unanswered questions, and the bigger picture
This month we’ve witnessed the global Avian flu outbreak, chocolates laced with salmonella, severe hepatitis of unknown cause among children, Ebola outbreak in West Africa, the first Polio case in Mozambique in 30 years, and . . . a global outbreak of monkeypox. I partnered with Dr.
·yourlocalepidemiologist.substack.com·
Monkeypox 101, unanswered questions, and the bigger picture
The curious case of AstraZeneca's Covid-19 vaccine
The curious case of AstraZeneca's Covid-19 vaccine
AstraZeneca’s Covid-19 vaccine is facing a crisis of confidence, as one country after another temporarily suspends the vaccine’s use.
·statnews.com·
The curious case of AstraZeneca's Covid-19 vaccine
Are we in a public health emergency?
Are we in a public health emergency?
We are clearly in the middle of an infection surge in the U.S. Hospitalizations are increasing but not reflecting case acceleration, and deaths are nearing pandemic lows. The individual risk of severe disease continues to decline thanks to immunity and treatments.
·yourlocalepidemiologist.substack.com·
Are we in a public health emergency?
Omicron as severe as other COVID variants -large U.S. study
Omicron as severe as other COVID variants -large U.S. study
The Omicron variant of the SARS-CoV2 virus is intrinsically as severe as previous variants, , according to a preprint version of a large U.S.studythat counters assumptions in other studies that it was more transmissible but less severe.
·reuters.com·
Omicron as severe as other COVID variants -large U.S. study
FDA limits use of Johnson & Johnson's Covid-19 vaccine, citing clotting risk
FDA limits use of Johnson & Johnson's Covid-19 vaccine, citing clotting risk
The FDA announced it was limiting access to Johnson & Johnson’s Covid-19 vaccine because of the risk of a clotting disorder that was discovered weeks after the vaccine was first put into use in the spring of 2021.
·statnews.com·
FDA limits use of Johnson & Johnson's Covid-19 vaccine, citing clotting risk
Impact of population mixing between vaccinated and unvaccinated subpopulations on infectious disease dynamics: implications for SARS-CoV-2 transmission
Impact of population mixing between vaccinated and unvaccinated subpopulations on infectious disease dynamics: implications for SARS-CoV-2 transmission
Background: The speed of vaccine development has been a singular achievement during the COVID-19 pandemic, although uptake has not been universal. Vaccine opponents often frame their opposition in terms of the rights of the unvaccinated. We sought to explore the impact of mixing of vaccinated and unvaccinated populations on risk of SARS-CoV-2 infection among vaccinated people. Methods: We constructed a simple susceptible–infectious–recovered compartmental model of a respiratory infectious disease with 2 connected subpopulations: people who were vaccinated and those who were unvaccinated. We simulated a spectrum of patterns of mixing between vaccinated and unvaccinated groups that ranged from random mixing to complete like-with-like mixing (complete assortativity), in which people have contact exclusively with others with the same vaccination status. We evaluated the dynamics of an epidemic within each subgroup and in the population as a whole. Results: We found that the risk of infection was markedly higher among unvaccinated people than among vaccinated people under all mixing assumptions. The contact-adjusted contribution of unvaccinated people to infection risk was disproportionate, with unvaccinated people contributing to infections among those who were vaccinated at a rate higher than would have been expected based on contact numbers alone. We found that as like-with-like mixing increased, attack rates among vaccinated people decreased from 15% to 10% (and increased from 62% to 79% among unvaccinated people), but the contact-adjusted contribution to risk among vaccinated people derived from contact with unvaccinated people increased. Interpretation: Although risk associated with avoiding vaccination during a virulent pandemic accrues chiefly to people who are unvaccinated, their choices affect risk of viral infection among those who are vaccinated in a manner that is disproportionate to the portion of unvaccinated people in the population.
·cmaj.ca·
Impact of population mixing between vaccinated and unvaccinated subpopulations on infectious disease dynamics: implications for SARS-CoV-2 transmission
Severe hepatitis outbreak among children
Severe hepatitis outbreak among children
Over the weekend, the WHO published a much anticipated update on an unusual outbreak of hepatitis among children spanning several countries. On April 21, the outbreak resulted in the CDC releasing a Health Alert. The cause of the outbreak is currently unknown, creating quite the mystery for disease detectives.
·yourlocalepidemiologist.substack.com·
Severe hepatitis outbreak among children
“This Shouldn’t Happen”: Inside the Virus-Hunting Nonprofit at the Center of the Lab-Leak Controversy
“This Shouldn’t Happen”: Inside the Virus-Hunting Nonprofit at the Center of the Lab-Leak Controversy
Chasing scientific renown, grant dollars, and approval from Dr. Anthony Fauci, Peter Daszak transformed the environmental nonprofit EcoHealth Alliance into a government-funded sponsor of risky, cutting-edge virus research in both the U.S. and Wuhan, China. Drawing on more than 100,000 leaked documents, a V.F. investigation shows how an organization dedicated to preventing the next pandemic found itself suspected of helping start one.
·vanityfair.com·
“This Shouldn’t Happen”: Inside the Virus-Hunting Nonprofit at the Center of the Lab-Leak Controversy
FDA OKs another Pfizer, Moderna COVID booster for 50 and up
FDA OKs another Pfizer, Moderna COVID booster for 50 and up
U.S. regulators on Tuesday authorized another COVID-19 booster for people age 50 and older, a step to offer extra protection for the most vulnerable in case the coronavirus rebounds. The Food and Drug Administration's decision opens a fourth dose of the Pfizer or Moderna vaccines to those people at least four months after their previous booster.
·apnews.com·
FDA OKs another Pfizer, Moderna COVID booster for 50 and up
Covid-19 pandemic isn't over for Black Americans, report warns
Covid-19 pandemic isn't over for Black Americans, report warns
In a searing new report, the Black Coalition Against COVID details the immense toll the pandemic continues to take on Black communities, and calls for continued vigilance and action to prevent further losses.
·statnews.com·
Covid-19 pandemic isn't over for Black Americans, report warns
Another mRNA booster or not?
Another mRNA booster or not?
A fourth mRNA dose has been underway in Israel for a few months now. The U.K. recently started a fourth dose for people over 75 years old and coined it “spring boosters.” In Germany, those over 70 years old are eligible for a fourth shot of the mRNA series.
·yourlocalepidemiologist.substack.com·
Another mRNA booster or not?