2016

Ivermectin has been repurposed as highly effective antiviral drug. Sadly, this is being ignored by US Medicine.

Ivermectin for COVID-19. Early treatment - 78% improvement, p < 0.0001. All studies - 71% improvement, p < 0.0001. 1 in 9 trillion probability results of the 58 studies are from an ineffective treatment (p = 1.1e-13).

Ivermectin Works For COVID-19 - LATEST STUDIES More lectures on drbeen.com Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Start your free trial - no credit card needed: https://members.drbeen.com/freetrial Original in-vitro study about Ivermectin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129059/ A study from bangladesh found that Ivermectin + Doxyclyclin significantly reduces mortality and morbidity in COVID-19 patients. https://clinicaltrials.gov/ct2/show/study/NCT04523831 A systemic review of the antiviral activity of Ivermectin https://www.nature.com/articles/s41429-020-0336-z https://journal.chestnet.org/article/S0012-3692(20)34898-4/fulltext PDF for the above study after it was accepted https://journal.chestnet.org/article/S0012-3692(20)34898-4/pdf Pre-print of the above study https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2 A search of various Ivermectin studies for your reading pleasure https://clinicaltrials.gov/ct2/results?cond=Covid19&term=ivermectin&cntry=&state=&city=&dist= Iota carrageenan and Ivermectin oral drops https://clinicaltrials.gov/ct2/show/results/NCT04425850?term=ivermectin&cond=Covid19&draw=2

Background: Innovative approaches are needed to complement existing tools for malaria elimination. Ivermectin is a broad spectrum antiparasitic endectocide clinically used for onchocerciasis and lymphatic filariasis control at single doses of 150 to 200 mcg/kg. It also shortens the lifespan of mosquitoes that feed on individuals recently treated with ivermectin. However, the effect after a 150 to 200 mcg/kg oral dose is short-lived (6 to 11 days). Modeling suggests higher doses, which prolong the mosquitocidal effects, are needed to make a significant contribution to malaria elimination. Ivermectin has a wide therapeutic index and previous studies have shown doses up to 2000 mcg/kg (ie, 10 times the US Food and Drug Administration approved dose) are well tolerated and safe; the highest dose used for onchocerciasis is a single dose of 800 mcg/kg. Objective: The aim of this study is to determine the safety, tolerability, and efficacy of ivermectin doses of 0, 300, and 600 mcg/kg/day for 3 days, when provided with a standard 3-day course of the antimalarial dihydroartemisinin-piperaquine (DP), on mosquito survival. Methods: This is a double-blind, randomized, placebo-controlled, parallel-group, 3-arm, dose-finding trial in adults with uncomplicated malaria. Monte Carlo simulations based on pharmacokinetic modeling were performed to determine the optimum dosing regimens to be tested. Modeling showed that a 3-day regimen of 600 mcg/kg/day achieved similar median (5 to 95 percentiles) maximum drug concentrations (Cmax) of ivermectin to a single of dose of 800 mcg/kg, while increasing the median time above the lethal concentration 50% (LC50, 16 ng/mL) from 1.9 days (1.0 to 5.7) to 6.8 (3.8 to 13.4) days. The 300 mcg/kg/day dose was chosen at 50% of the higher dose to allow evaluation of the dose response. Mosquito survival will be assessed daily up to 28 days in laboratory-reared Anopheles gambiae s.s. populations fed on patients’ blood taken at days 0, 2 (Cmax), 7 (primary outcome), 10, 14, 21, and 28 after the start of treatment. Safety outcomes include QT-prolongation and mydriasis. The trial will be conducted in 6 health facilities in western Kenya and requires a sample size of 141 participants (47 per arm). Sub-studies include (1) rich pharmacokinetics and (2) direct skin versus membrane feeding assays. Results: Recruitment started July 20, 2015. Data collection was completed July 2, 2016. Unblinding and analysis will commence once the database has been completed, cleaned, and locked. Conclusions: High-dose ivermectin, if found to be safe and well tolerated, might offer a promising new tool for malaria elimination.

Caly et al.1 reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using ivermectin at 5 μM. The concentration resulting in 50% i...

People are dying, but what are they dying from? Is it an all-powerful virus that is doing hundreds of thousands of people in, or is it medical ignorance and medical malpractice? Ignorance is deadly in medicine and is usually sourced in arrogance and pharmaceutical greed and power, which is in full view with the American... View Article

Will Ivermectin Block a Vaccine? A very common question asked is, if Ivermectin will block the effect of a vaccine? We will discuss the vaccine’s lifecycle in our body and if the Ivermectin’s presence cause any issues? We will also discuss Virus’ lifecycle and see how Ivermectin works there. We will also compare and contrast the effect of the Ivermectin for a vaccine and the virus (SARS-COV-2) Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Discuss various topics on DrBeen forum: https://members.drbeen.com/forum/ #drbeen #koolbeens #COVID

Nasal Spray for Virus/SARS-COV-2 Reduction A Canadian company has successfully run trials and tests to show that nitric oxide based nasal spray can reduce viral replication by 99.99% in 72 hours. Let’s look at this spray, the test results, and its mechanism of action for viruses. Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Pre-read/watch DrBeen’s discussion about N-AcetylCysteine https://youtu.be/K8kKWgsGIU8 About Cysteine and Cystine https://www.sciencedirect.com/topics/chemistry/sulfur-containing-amino-acid saNotize nasal spray site. https://sanotize.com/covid-19/ About NO https://sanotize.com/why-nitric-oxide/ About neuraminidase inhibitors https://en.wikipedia.org/wiki/Neuraminidase_inhibitor About neuraminidase https://en.wikipedia.org/wiki/Neuraminidase About NO from Goodman Gillman for reference Platelet activation and coagulation do not normally occur within an intact blood vessel. Thrombosis is prevented by several regulatory mechanisms that require healthy vascular endothelium. Nitric oxide and prostacyclin synthesized by endothelial cells inhibit platelet activation Produced by activated helper T (TH) and natural killer (NK) cells, IFN-γ enhances the microbicidal activity of macrophages by inducing mammalian inducible nitric oxide synthase (iNOS, also called NOS2), thereby increasing their production of nitric oxide (NO) and their capacity to kill intracellular pathogens. Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) . McGraw-Hill Education. Kindle Edition. #drbeen #koolbeens #COVID

[vc_row css=”.vc_custom_1585688571105{padding-top: 50px !important;padding-bottom: 15px !important;}”][vc_column width=”1/2″][vc_column_text] NORS as an upper airway “disinfectant” SaNOtize has demonstrated the effectiveness of its NORS formulation in eradicating different types of viruses, including influenza and H1N1, and is working diligently to determine its efficacy for preventing and treating COVID-19 infections. At present, SaNOtize: Completed a randomized, double-blind, placebo-controlled trial that evaluated […]

UK Clinical Trial for A Nasal Spray for COVID - Amazing Results Today we will discuss the UK clinical trial of the nitric oxide based nasal spray. Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US UK Clinical Trial Confirms SaNOtize’s Breakthrough Treatment for COVID-19 https://www.businesswire.com/news/home/20210315005197/en/UK-Clinical-Trial-Confirms-SaNOtize%E2%80%99s-Breakthrough-Treatment-for-COVID-19 DrBeen’s earlier video about this product https://youtu.be/u-e_XYYHApA #drbeen #koolbeens #COVID

Acute Respiratory Distress Syndrome (ARDS) causes up to 40% mortality in humans and is difficult to treat. ARDS is also one of the major triggers of mortality associated with coronavirus-induced disease (COVID-19). We used a mouse model of ARDS induced by Staphylococcal enterotoxin B (SEB), which tr …

The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeut …

Effective treatment choices to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited because of the absence of effective target-based therapeutics. The main object of the current research was to estimate the antiviral activity of cannabinoids (CBDs) against the human coronavir …

We discussed evident effects of aloe-emodin and aloe polysaccharide on the therapy of viral infections and epigenetic factor butyrate that is involved in latency and reactivation in viral infection. Furthermore we presented eight case reports of Kampo medicine with Aloe vera juice (AVJ) to virus infections. Kampo medicine with AVJ-successive ingestion demonstrates to be suitably personalized medicine for virus infections and improves gut-microbial ecosystem in host. The potential Kampo medicine with AVJ may provide fresh insights as an anti-virus medicine for homeostatic regulation in host.

The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce bronchodilatory and vasodilatory effects. Stu …

A set of evolving, cautious hunches and predictions.

Urtica dioica agglutinin (UDA) is a small plant monomeric lectin, 8.7 kDa in size, with an N-acetylglucosamine specificity that inhibits viruses from Nidovirales in vitro. In the current study, we first examined the efficacy of UDA on the replication of different SARS-CoV strains in Vero 76 cells. U …

It’s been over six weeks since Iowa dropped all state-level COVID restrictions, and surprise, surprise, hospitalized patients are down 54 percent. But if you try to Google this information, all you will see is death, dying, and it must be the end of the world because of COVID, which miraculously seems to be a cure... View Article

Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections&mdash;including the current pandemic strain SARS-CoV-2&mdash;that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage.

‘Doctors say CDC should warn people the side effects from Covid vaccine shots won’t be a walk in the park.’ Be warned to expect severe reactions to the new COVID vaccines. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, told reporters he was not certain what is causing all the vaccine reactions. But... View Article

Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory ...

We describe the antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome cor…

Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapid …