2016

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Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals | ACS Chemical Biology
Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals | ACS Chemical Biology
Recent advances in sequencing techniques unveiled the vast potential of ribosomally synthesized and post-translationally modified peptides (RiPPs) encoded in microbiomes. Class I lantibiotics such as nisin A, widely used as a food preservative, have been investigated for their efficacy in killing pathogens. However, the impact of nisin and nisin-like class I lantibiotics on commensal bacteria residing in the human gut remains unclear. Here, we report six gut-derived class I lantibiotics that are close homologues of nisin, four of which are novel. We applied an improved lantibiotic expression platform to produce and purify these lantibiotics for antimicrobial assays. We determined their minimal inhibitory concentration (MIC) against both Gram-positive human pathogens and gut commensals and profiled the lantibiotic resistance genes in these pathogens and commensals. Structure–activity relationship (SAR) studies with analogs revealed key regions and residues that impact their antimicrobial properties. Our characterization and SAR studies of nisin-like lantibiotics against both pathogens and human gut commensals could shed light on the future development of lantibiotic-based therapeutics and food preservatives.
·pubs.acs.org·
Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals | ACS Chemical Biology
How To Take NAC - YouTube
How To Take NAC - YouTube
My go-to for NAC Supplementation:https://www.glutenfreesociety.org/shop/health-focus/immune-health/ultra-nac-500/NAC (N-acetylcysteine) is a versatile and su...
·youtube.com·
How To Take NAC - YouTube
An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial - PubMed
An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial - PubMed
All Ambrotose treatments were well-tolerated. There were no differences among treatments in heart rate or blood pressure across time. Self-reported well-being scores were generally higher for the Ambrotose treatments but there were no changes of statistical significance across time (p > 0. …
·pubmed.ncbi.nlm.nih.gov·
An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial - PubMed
Efficacy of a vaginal suppository formulation prepared with Acacia arabica (Lam.) Willd. gum and Cinnamomum camphora (L.) J. Presl. in heavy menstrual bleeding analyzed using a machine learning technique
Efficacy of a vaginal suppository formulation prepared with Acacia arabica (Lam.) Willd. gum and Cinnamomum camphora (L.) J. Presl. in heavy menstrual bleeding analyzed using a machine learning technique
Objective: This study aims to determine the efficacy of the Acacia arabica (Lam.) Willd. and Cinnamomum camphora
·frontiersin.org·
Efficacy of a vaginal suppository formulation prepared with Acacia arabica (Lam.) Willd. gum and Cinnamomum camphora (L.) J. Presl. in heavy menstrual bleeding analyzed using a machine learning technique
TUCKER, PUTIN, AND LEGACY’S WAR ON JOURNALISM - The HighWire
TUCKER, PUTIN, AND LEGACY’S WAR ON JOURNALISM - The HighWire
In light of the firestorm Tucker Carlson’s historic interview with Russian President Vladimir Putin has created, Del reflects on the danger of the mainstream media’s overwhelming success spinning news stories and why this may signal the end of freedom of the press. POSTED: February 9, 2024
·thehighwire.com·
TUCKER, PUTIN, AND LEGACY’S WAR ON JOURNALISM - The HighWire