2016

Inflammatory bowel disease (IBD) often coexists with depression, posing considerable challenges for treatment. This study aimed to investigate the the…

The hypoglycemic effects of low-molecular-weight Laminaria japonica polysaccharide (LJO) were investigated in type 2 diabetes mellitus (T2DM) mice, fo…

🍀❤️🍀 Pastor Steve Cioccolanti gives a prophetic update ▶️ Watch the rest of this video & support the ministry: https://vimeo.com/stevecioccolanti/vod_pages...

(NaturalHealth365) Scientists reveal how obesity fuels the aggressive growth of cancer. Find out what Western medicine fails to recognize.

(NaturalHealth365) New research reveals how carrots can reduce your risk of multiple forms of cancer. Discover what the study found.

(NaturalHealth365) New study links gut health to later-life arrhythmias in individuals with inflammatory bowel disease.

This is an excerpt from a Prophecy Watchers podcast titled "The Biblical Plan for Mideast Peace" which previously aired here on 11/30/23.Thanks For Watching...

Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in lipid accumulation-mediated foam cell formation. The stimulation of autophagy is crucial for the recovery of cellular recycling process. One of the potential autophagy inducers is trehalose, a naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its hydrophilic nature which results in poor penetration through cell membranes. To enhance its bioavailability, we developed trehalose-releasing nanogels (TNG) for the treatment of atherosclerosis. The nanogels were fabricated through copolymerization of 6-O-acryloyl-trehalose with the selected acrylamide-type monomers affording a high trehalose conjugation (~ 58%, w/w). TNG showed a relatively small hydrodynamic diameter (dH, 67 nm) and a uniform spherical shape and were characterized by negative ζ potential (-18 mV). Thanks to the trehalose-rich content, TNG demonstrated excellent colloidal stability in biological media containing serum and were non-hemolytic to red blood cells. In vitro study confirmed that TNG could stimulate autophagy in foam cells and enhance lipid efflux and in vivo study in ApoE−/− mice indicated a significant reduction in atherosclerotic plaques, while increasing autophagic markers. In conclusion, TNG hold great promise as a trehalose delivery system to restore impaired autophagy-mediated lipid efflux in atherosclerosis and subsequently reduce atherosclerotic plaques. Graphical abstract

Carbohydrates are a structurally-diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Many diseases have been correlated with changes in the composition ...

Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, little is known about how GAH functions in angiogenesis. To determine the role of GAH on vascular development and impairment repair, we used the inhibitors VRI, DMH1, and dorsomorphin (DM) to construct vascular-impaired models in Tg(kdrl: mCherry) transgenic zebrafish. We then treated with GAH and measured its repair effects on vascular impairment through fluorescence intensity, mRNA, and protein expression levels of vascular-specific markers. Our results indicate that GAH promotes vascular development and repairs impairment by regulating the vascular endothelial growth factor (VEGF) signaling pathway through modulation of bone morphogenetic protein (BMP) signaling. This study provides an experimental basis for the development of GAH as a drug to repair vascular diseases.

Anti-Inflammatory Properties of Glucosamine Used in Combination with Plants Extracts on Adjuvant Arthritis Rat. PubMed, SCI, Scopus, ESCI, PMC indexed

Raft-forming systems are designed to relieve reflux symptoms by forming a physical barrier on top of the stomach. The present study aimed to evaluate …

(NaturalHealth365) The latest unsettling revelation is the presence of DNA fragments in mRNA COVID shots. Read this article to learn more.

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(NaturalHealth365) Just how safe and effective statins are? Experts raise concerns about their supposed benefit in reducing heart disease.

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Scientist Paul Garner joins us again to discuss his book “Fossils and the Flood.” Informed by the latest creationist scholarship and richly illustrated—this ...

Should Christians keep the Sabbath or Sunday? It is a very controversial question. Or should they keep both? And more important than observing it is HOW shou...

The Bible says that before The Second Coming of Christ, all nations will be gathered to Jerusalem. Bible prophecy says “peace and security” will be declared ...

Have the writings of the Watchers or Fallen Angels been discovered in a PREFLOOD CITY in Turkey? Do these ruins warn about both the Flood and the final destr...

In this video, Calvin Smith takes a deep dive into the amazing kinesin protein. Unfortunately, evolutionists will claim that this protein is the result of ch...

(NaturalHealth365) A multinational study found an alarming link between CT scans in one’s youth and the development of cancer.

Background and Purpose Diabetic vascular complication is a leading cause of disability and mortality in diabetes patients. Low molecular weight fucoidan (LMWF) is a promising drug candidate for diab...

Radiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to ev...

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Allulose in human diet: the knowns and the unknowns - Volume 128 Issue 2