Awakening from Alzheimers

Dr. Dale Bredesen brings a personalized medicine approach to Alzheimer's treatment and he's seeing success and improvements in brain function.

Compared with a usual diet supplemented with low-fat healthy-eating guidelines, patients on the ketogenic diet improved in daily function and quality of...

In our discussions in recent years about Alzheimer's disease, certainly one dietary recommendation seems to gain the spotlight and that is a diet that helps produce ketones. To be fair, most of the support for a ketogenic diet thus far has been theoretical although early animal research has been supportive. Now, I'm excited to report that an actual interventional trial using the ketogenic diet in Alzheimer's patients has been completed and has demonstrated quite remarkable results. The study, performed by my friend Dr. Matthew Phillips in New Zealand, demonstrated significant improvement in a variety of parameters in Alzheimer's patients who were placed on a ketogenic diet in comparison to their standard diet. Here is the actual study: https://www.drperlmutter.com/study/randomized-crossover-trial-of-a-modified-ketogenic-diet-in-alzheimers-disease/ https://www.drperlmutter.com/ketogenic-diet-proves-effective-in-alzheimers-disease/ Many of you may remember Dr. Phillips as he appeared on the podcast in the past describing his results of using a ketogenic diet, successfully, in Parkinson's disease: https://www.drperlmutter.com/the-empowering-neurologist-with-dr-matthew-phillips/ Here's more information about him. ==== Matt is a full-time clinical and research neurologist at Waikato Hospital, Hamilton, New Zealand. His foremost passion is to explore the potential feasibility, safety, and efficacy of metabolic therapies, particularly fasting and ketogenic diets, in creating alternate metabolic states that may improve not only the symptoms, but also function and quality of life, for people with a variety of difficult disorders. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

Drs. Ayesha and Dean Sherzai are the authors of The 30-Day Alzheimer’s Solution. It is most user-friendly book dedicated to brain health.

During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer’s disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.

In Alzheimer’s disease (AD), amyloid-β (Aβ) oligomers are considered key mediators of synaptic dysfunction and cognitive impairment. These unstable intermediate Aβ species can interfere with different cellular organelles, leading to neuronal cell death, through the formation of Ca2+-permeable membrane pores, impairment in the levels of acetylcholine neurotransmitters, increased insulin resistance, promotion of pro-inflammatory cascades, among others. Based on a series of evidences that indicate the key role of glycosaminoglycans (GAGs) in amyloid plaque formation, we evaluated the capacity of four monosaccharides, i.e., glucosamine (GlcN), N-acetyl glucosamine (GlcNAc), glucosamine-6-sulfate (GlcN6S), and glucosamine-6-phosphate (GlcN6P), to reduce the Aβ-mediated pathological hallmarks. The tested monosaccharides, in particular, GlcN6S and GlcN6P, were able to interact with Aβ aggregates, reducing neuronal cell death, Aβ-mediated damage to the cellular membrane, acetylcholinesterase activity, insulin resistance, and pro-inflammation levels.

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Drugs being used to treat Alzheimer’s disease are actually associated with a more aggressive decline in cognitive function.

Exercise, which has a positive impact on brain health, needs to be front and center in terms of our Alzheimer’s messaging and outreach.

A new study highlights the role lifestyle factors, like sleep, exercise, stress, and weight gain can have on your risk of developing Alzheimer's disease.

Do you ever worry about you or a loved one getting Alzheimer’s disease? It’s heartbreaking to watch someone you love not remember who you are or have difficulties with everyday tasks. The sacred plant is effective in preventing these symptoms of cognitive decline by reducing brain inflammation due to aging and by restoring a process called neurogenesis. Watch as Dr. Daniel Stein, a cannabis Neurologist, shares what he refers to as a “type 3” preventative protocol. *** This limited clip is a preview from our Healing Brain Masterclass. Get full access to our entire 3 masterclass library, complete season 1 docuseries, and over 37 bonuses on a portable 100+ GB flash drive... Go here for all the details 👉 http://bit.ly/2rl3F33

New research has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer's disease.

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 …

The Alzheimer's brain can't handle glucose effectively, which is why this unique saturated fat may hold the key to improving and even reversing the condition in some patients

New research connects some very important dots and gives further substantiation to the idea that coffee is good for the brain.

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. As the aging population is increasing, AD is becoming one of the leading causes of disability and death among the elderly. However, currently there is no cure for this disease. Fucoidan is a complex sulfated polysaccharide ma

Europe PMC is an archive of life sciences journal literature.