Eyes

As medical professionals search for new ways to personalize diagnosis and treatment of disease, researchers have already put into practice what may be the next big step in precision medicine: personalized proteomics.

Our previous research revealed that trehalose, a nonreducing disaccharide of glucose and an important stress responsive factor, proved to have anti-inflammatory, antiapoptotic, and particularly antioxidant properties in UVB-irradiated corneas. Trehalose reduced oxidative stress in corneas induced by …

Purpose To analyze the association between glucosamine (GlcN) use and the risk of age-related macular degeneration (AMD) using claims data from the National Health Insurance Research Database (NHIRD). Methods A retrospective, population-based study was conducted with NHIRD data from a 14-year period (2000–2013). Chi-squared and Student’s t-tests were used to evaluate differences between the study and comparison cohorts for categorical and continuous variables, respectively. Risk factors for disease development were examined by the adjusted hazard ratio (aHR) with 95% confidence interval. Kaplan-Meier analysis was performed to compare the cumulative risk of AMD between the two cohorts. Results In total, 1,344 patients with GlcN treatment were enrolled in the study cohort and 5,376 patients without GlcN use were enrolled in the comparison cohort. The incidence rate of AMD was lower with GlcN use (3.65%) than without GlcN use (5.26%) (P = 0.014). GlcN use was associated with a lower risk of developing AMD among patients with hyperlipidemia, coronary artery disease, chronic obstructive pulmonary disease, stroke, other neurological disorders, or degenerative arthritis. Although the incidence of wet type AMD did not significantly differ (P = 0.91), the incidence of dry type AMD was lower in patients with GlcN use (2.9%) than those without GlcN use (4.84%) (P = 0.003). Kaplan-Meier analysis similarly revealed a lower rate of dry type AMD in patients with GlcN use compared to those without GlcN use (log-rank P = 0.004). Conclusions GlcN treatment can decrease the risk of developing dry type AMD. Further prospective controlled studies are needed to determine the effectiveness of GlcN treatment in patients with AMD and the associated mechanism.

Click here to subscribe - https://www.glutenfreesociety.org/wxrn Many of these nutrients have been studied with respect supporting eye health and preventing vision decline. Nutrition has gained tremendous respect thanks to the ability of these key nutrients to support long-term eye health. Interestingly, over time, our food system has become flooded with processed foods devoid of nutrients, and our produce has become less nutrient dense thanks to commercial farming practices. While food was once enough for healthy eyes and vision, it is now more difficult to achieve eye health while aging without attention to these key nutrients. Conditions like gluten sensitivity and celiac that can cause malabsorption even further exacerbate the need for attention to nutrition and supplementation in order to support long-term eye health and vision. One study enrolled 3,640 patients with AMD and declining visual acuity to administer high-dose vitamins C and E, beta carotene, and zinc supplements. Comparison with the placebo group demonstrated a statistically significant odds reduction for the development of advanced AMD by supplementing with the antioxidants plus zinc. The study followed these patients for up to nine years. Another study evaluated the effect of multivitamin supplements and vitamin E on patients at risk of nuclear opacification. In regular users of multivitamin supplements, the risk of nuclear opacification was reduced by one third. In regular users of vitamin E supplements and persons with higher plasma levels of vitamin E, the risk was reduced by approximately half. Another large, randomized study found that women taking B vitamins (including folate and vitamin B12) reduced their risk of early macular degeneration by more than a third after seven years. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

Thieme E-Books & E-Journals

raphs to document changes over time with A. vera-based topical treatment. Results: The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years. Conclusions: Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment....

Cornea acts as a structural barrier and protects the eye from environmental stresses. Inflammation in ocular surface causes discomfort and visual dist…

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential ...

Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. Although trehalose is not synthesized by …

Our findings demonstrate that trehalose, functioning as an autophagy enhancer, suppresses the inflammatory response by promoting autophagic flux via TFEB activation in primary HCECs exposed to hyperosmotic stress, a process that is beneficial to dry eye.

(2018). Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy: Vol. 14, No. 8, pp. 1419-1434.

ANOVA: analysis of variance; Atg7: autophagy related 7; AV: autophagic vacuoles; CD68: cd68 antigen; ERG: electroretinogram; ERT: enzyme replacement therapy; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFAP: glial fibrillary acidic protein; GNAT2: guanine nucleotide binding protein, alpha trans …

For many years, scientists believed patients developed retinopathy and, as a result of the damage to the blood vessels, later developed neuropathy. In a new study, however, researchers discovered that the sequence of events occurring in the retina due to diabetes is just the opposite of these long-held beliefs.

Scientists have demonstrated a method for generating several key types of eye tissue from human stem cells in a way that mirrors whole eye development.

It was Labor Day 2015 when Rosetta Ivey-Foster, a 76-year-old retired bank clerk, learned first-hand how quickly diabetes can deteriorate vision. Swift action restored most of her eyesight.

1) Learn 3 key nutrients that can cure your dry eyes! 2) Light therapy might be the next big advance in treating dry eyes 3) Why Restasis is the one of the most damaging eye drops and why you should avoid this medication at all costs 4) Why fish oils might be making your dry eyes worse 5) A 10 second test to find out if you are deficient in this key mineral that is linked to dry eyes! 6) How the simply act of drinking enough water can improve eyesight! 7) A simple, non-invasive treatment that can stimulate tear production and improve your symptoms of dry eyes immediately! And much more! http://www.healingtheeye.com/products-dry-eye-eye-drops.html