Glycocalyx

15 early warning signs all point to a single hidden problem. Your microvascular system may be breaking down, and your organs could be slowly starving and you don’t even know it. These early warning signs may be caused by a problem hidden in the smallest blood vessels in your body—your microscopic capillaries. Learn more at https://microvascular.com/.

The cerebral microcirculation and its glycocalyx, a matrix coating the luminal endothelium, are key regulators of capillary permeability and cerebral …

Carbohydrates are a structurally-diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Many diseases have been correlated with changes in the composition ...

Background and Purpose Diabetic vascular complication is a leading cause of disability and mortality in diabetes patients. Low molecular weight fucoidan (LMWF) is a promising drug candidate for diab...

Abstract Aims Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose […]

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Angiogenesis - Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory...

Abstract Aims Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose […]

Abstract Background Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is […]

We present evidence that the 0.5 microm thick gel layer, lining the inner wall of healthy blood vessels, the glycocalyx, is the first line of defence against atherothrombotic disease. All blood vessel linings are coated with this gel, a highly negatively charged structure, rich in anionic sites most …

High-intensity interval training (HIIT) has been proposed to exert vasculoprotective effects. This study aimed to evaluate whether HIIT affects the microvasculature, including the endothelial glycocalyx barrier, and to identify associated microRNAs (miRNAs). Fifty healthy participants (23.1 ± 3.0 yr) performed a 4-wk 4 × 30-s all-out running HIIT. Sidestream dark-field imaging was performed at baseline and follow-up to detect changes of the sublingual microvasculature including the endothelial glycocalyx. Exercise parameters were determined by continuous running field test and documentation of high-intensity runs. miRNAs potentially associated with glycocalyx thickness were selected by structured literature search and blood samples for miRNA, and lactate measurements were drawn at baseline and follow-up HIIT. At baseline, a correlation between maximal exercise performance capacity and glycocalyx thickness (determined by perfused boundary region) was detected (P = 0.045, r = 0.303). Increased exercise performance at follow-up also correlated with glycocalyx thickness (P = 0.031, r = 0.416), and increased high-intensity sprinting speed was associated with an increased number of perfused vessels (P = 0.0129, r = 0.449). Literature search identified miR-143, -96-5p, and -24, which were upregulated by HIIT already at baseline and showed an association with peak blood lactate levels after sprints (all P < 0.05). Moreover, increased baseline miR-143 levels predicted increased glycocalyx thickness at follow-up (AUCmiR-143 = 0.92, 95% confidence interval, 0.81–1.0, P = 0.0008). Elevated resting miR-126 levels after the intervention were associated with cell-free versican mRNA levels. We conclude that HIIT induces changes in the endothelial glycocalyx of the microvasculature. Associated miRNAs such as miR-143 may represent a tool for monitoring early vasculoprotective adaptations to physical activity. NEW & NOTEWORTHY High-intensity interval training is known to improve health-related fitness in general and in lifestyle-induced chronic diseases. To visualize microvasculature structure and to detect exercise-induced changes, sublingual sidestream dark-field imaging microscopy was used, and circulating miRNAs were measured. This study shows that exercise-induced changes correlate with associated circulating miRNA, which might be useful for monitoring vasculoprotective effects. Furthermore, sidestream dark-field imaging may represent a sensitive tool for the early detection of exercise-induced systemic vascular changes.

Healthcare Providers guide to Arterosil® - the only product in the world that has been clinically proven to rebuild the endothelial glycocalyx

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The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic conductivity, ...

Dr. Hans VInk discusses the endothelial glycocalyx: your vascular system's first line of defense.

Years of research have exposed an understanding of the function and structure of the protective gel lining in your circulatory, or vascular system, called the glycocalyx. A new, proprietary, patent-pending dietary supplement named Endocalyx, is specifically formulated to deliver the building blocks essential to maintain a healthy glycocalyx and microvascular system. The ingredients are sourced from regions around the world where people are known to live longer and live healthy active lives. Endocalyx is made from concentrated extracts of seven natural ingredients. These ingredients contain the same compounds that make up and protect the structure of the glycocalyx. It’s a specific blend, right down to the molecular structure that makes all the difference in the result of taking Endocalyx daily. This patent-pending combination of ingredients, in specific dosage amounts, stimulate three actions that restore, rejuvenate and protect your glycocalyx and microvascular system. The first result of this specific blend comes from polysaccharides that restore the protective structure of the glycocalyx. The second result comes from the amino sugars that rejuvenate your body’s ability to produce more of the glycocalyx protective gel. And the third result comes from antioxidants that work to protect the glycocalyx from breaking down. Scientific research backs up that these synergistic ingredients, when combined together, deliver these vital results in your microvascular system. In fact, several Universities and hospitals around the world are conducting research projects right now. And the list of research papers written by medical professionals continues to grow. And importantly, a growing list of researchers now understand the paradigm-shifting advantages of combining these ingredients. As Endocalyx strengthens the glycocalyx, it helps optimize the structure of the capillaries. From head to toe, optimal capillary function delivers many benefits, including clearer thinking, increased energy, improved performance, more youthful appearance, and greater comfort. The better each brain cell is supplied with oxygen and nutrients, the better your mood, the clearer your mind, the more productive your thinking.* Healthy skin, hair, and eyes depend on a steady supply of oxygen and nutrients in order to renew, grow, and stay healthy.* Skin color and tone are enhanced.* Your hair and nails are stronger and healthier.* And your eyes are clearer and brighter.* As Endocalyx strengthens the glycocalyx, the blood in your entire vascular system is better able to reach and energize each cell of your body. Then all the cells of your body, including your brain, heart, and muscles, are amply supplied with oxygen and nutrients.* This means that more blood cells, carrying more nutrients and vital oxygen to all of your muscle, skin, and nerve cells, restore warmth, feeling and comfort.* Don’t wait another minute! Wake up and listen to your body’s early warning signs that your glycocalyx and microvascular system is breaking down. Take control of tomorrow now by starting daily use of Endocalyx today. It’s not too late to restore, rejuvenate and protect your glycocalyx and microvascular system. Order now and save $20 with monthly autoship … and get free shipping at Microvascular.com. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in type 1 diabetic patients with microalbuminuria (DM1-MA group; n = 7), without microalbuminuria (DM1-NA group; n = 7), and in age-matched control subjects (CON; n = 7). Systemic glycocalyx volume was determined comparing intravascular distribution volume of a glycocalyx-permeable tracer (dextran 40) to that of a glycocalyx-impermeable tracer (labeled erythrocytes). Sublingual capillaries were visualized using orthogonal polarization spectral microscopy to estimate microvascular glycocalyx. Patients and control subjects were matched according to age and BMI. Glycocalyx volume decreased in a stepwise fashion from CON, DM1-NA, and finally DM1-MA subjects (1.5 ± 0.1, 0.8 ± 0.4, and 0.2 ± 0.1 l, respectively, P < 0.05). Microvascular glycocalyx in sublingual capillaries was also decreased in type 1 diabetes versus the control group (0.5 ± 0.1 vs. 0.9 ± 0.1 μm, P < 0.05). Plasma hyaluronan, a principal glycocalyx constituent, and hyaluronidase were increased in type 1 diabetes. In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria.

Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker for glycocalyx ...

Our Microvascular supplement improves Glycocalyx Health effectively. Endocalyx™ has been clinically shown to maintain blood flow circulation. Shop online now!

Non-invasive GlycoCheck testing technology quantifies vessel density, red blood cell concentration, blood flow and glycocalyx function.

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