COVID-19

373 bookmarks
Newest
Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study
Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study
"In this study, we observed that the majority of working age patients with PCS did not recover in the second year of their illness. Patterns of reported symptoms remained essentially similar, non-specific and dominated by fatigue, exercise intolerance and cognitive complaints."
Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study
Neurocognitive Impairment in Long COVID: A Systematic Review
Neurocognitive Impairment in Long COVID: A Systematic Review
Of the 516 studies assessed for eligibility, 36 studies met the inclusion criteria. All included studies support the presence of persistent cognitive changes after COVID-19 disease. Executive function, memory, attention, and processing speed appear to be the cognitive domains that are predominantly associated with long-COVID syndrome, whereas language is an area that has not been sufficiently investigated.
Neurocognitive Impairment in Long COVID: A Systematic Review
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
SARS-CoV-2 causes vascular dysfunction by stiffening endothelial cells, even without fully replicating in them. This applies to multiple variants (Alpha, Beta, Delta). This stiffening (loss of elasticity) disrupts blood flow regulation, promotes inflammation, and increases clotting risk. The study highlights endothelial dysfunction as a direct viral effect, not just due to systemic inflammation or cytokines.
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
Mid and long-term neurological and neuropsychiatric manifestations of…
Mid and long-term neurological and neuropsychiatric manifestations of…
Researchers analyzed 18 studies covering 10,530 patients to assess neurological and mental health symptoms after COVID-19. The most common symptoms were fatigue (37%), brain fog (32%), memory problems (28%), attention issues (22%), muscle pain (17%), loss of smell (12%), taste changes (10%), and headaches (15%). Mental health symptoms included sleep disturbances (31%), anxiety (23%), and depression (17%), which became more common over time
Mid and long-term neurological and neuropsychiatric manifestations of…
MSK Library Guides: COVID Impacts: Cardiovascular
MSK Library Guides: COVID Impacts: Cardiovascular
"While COVID-19 is considered a "respiratory virus", it manifests through the entire body. Cardiovascular complications have been well-documented in acute COVID-19 infection, and recent research is showing that it also causes significant cardiovascular manifestations in the post-acute phase of the disease."
MSK Library Guides: COVID Impacts: Cardiovascular
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
This long-term study suggests that individuals recovering from COVID-19 continue to experience cognitive complaints, psychiatric and neurological symptoms, and brain functional alteration. The MRI results indicated that the changes in brain function in regions such as the putamen, temporal lobe, and superior parietal gyrus may contribute to cognitive complaints in individuals with long COVID even 2 years after acute infection.
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Researchers at Children’s Hospital of Philadelphia (CHOP) have found elevated levels of a biomarker related to blood vessel damage in children with SARS-CoV-2 infection, even if the children had minimal or no symptoms of COVID-19. They also found that a high proportion of children with SARS-CoV-2 infection met clinical and diagnostic criteria for thrombotic microangiopathy (TMA). TMA is a syndrome that involves clotting in the small blood vessels and has been identified as a potential cause for severe manifestations of COVID-19 in adults.
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
People with long COVID have symptoms such as pain, extreme fatigue and “brain fog,” or difficulty concentrating or remembering things. As of March 2023, the syndrome was estimated to affect more than 15 million adults in the U.S., and a 2022 report found that it had forced between two million and four million Americans out of the workforce. Long COVID often arises in otherwise healthy young people, and it can follow even a mild initial infection.
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19
Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19
Examining data in over 1 million children from medical records, the incidence of type I diabetes diabetes was increased 2x among those infected with COVID-19 in the first 3 months post-COVID, but risk remained elevated up to 15 months compared to those without a diagnosis of COVID.
Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19
Sex Differences in Long COVID
Sex Differences in Long COVID
Cohort study of 12,276 people found female sex is associated with 31% increased risk of LongCovid. the risk was highest in the 40-55 age group of non-menopausal women.
Sex Differences in Long COVID
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) based on self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections using a cohort of adults with and without SARS-CoV-2 infection.
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
Long COVID science, research and policy
Long COVID science, research and policy
Nature Medicine - This Review outlines the current state of scientific evidence on long COVID, discusses its impacts on patients, health systems, economies and global health metrics, and proposes a...
Long COVID science, research and policy
Experiences of Canadians with long-term symptoms following COVID-19
Experiences of Canadians with long-term symptoms following COVID-19
This study uses data from the Canadian COVID-19 Antibody and Health Survey to describe the current COVID-19 landscape, including infection, reinfection, and acute and long-term symptoms. This study also examines how peoples’ experiences with the virus have evolved in the context of growing immunity, emerging variants, new treatments, and relaxation of public health measures.
Experiences of Canadians with long-term symptoms following COVID-19
Understanding Cumulative Risk
Understanding Cumulative Risk
"Two years ago, one of us made a prediction in Fortune Magazine that a few years of ‘learning to live with’ COVID (i.e., pretending it doesn’t exist) would lead to a billion cases of Long COVID. A recent estimate pegs the total incidence so far at 400 million cases of Long COVID. Long COVID is well on its way to becoming the world’s most common disease."
Understanding Cumulative Risk
Does COVID increase the risk of Alzheimer’s disease?
Does COVID increase the risk of Alzheimer’s disease?
COVID-19, even in mild cases, is linked to changes in Alzheimer’s disease-related brain biomarkers comparable to four years of aging. This study raises concerns about long-term neurological risks and cognitive decline post-COVID.
Does COVID increase the risk of Alzheimer’s disease?
I Love You. Please Find Someone Else. - The New York Times
I Love You. Please Find Someone Else. - The New York Times

I had heard of the life-altering fatigue of long Covid, which turned doing the dishes into a marathon requiring several breaks and a nap. I didn’t know, however, that the illness would trigger in me a painful allergic reaction to sunshine, or trigeminal neuralgia (imagine wearing an electric fishnet as a mask), or the dozen other bizarre symptoms that left me feeling as if an essential screw holding me together had come loose.

I became housebound overnight. I was 37. Loving your partner “in sickness” sounds noble, romantic even. In reality, it’s gut wrenching.

I Love You. Please Find Someone Else. - The New York Times
SARS-CoV-2 evolution on a dynamic immune landscape
SARS-CoV-2 evolution on a dynamic immune landscape
Nature - A modelling approach predicts SARS-CoV-2 variant dynamics on the basis of immunity and cross-neutralization, which was shaped by a region’s SARS-CoV-2 infection history.
SARS-CoV-2 evolution on a dynamic immune landscape
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
Around 11.6% of toddlers born to mothers with lab-confirmed SARS-CoV-2 infection during pregnancy showed cognitive, motor, or language problems indicative of neurodevelopmental delays. By comparison, only two of 128 unexposed controls — 1.6% — showed such issues.
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero