If You’ve Had COVID-19, Chronic Fatigue Syndrome Could Be Next
COVID and Chronic Fatigue Syndrome have a lot of overlapping symptoms and researchers are beginning to wonder if the two could be related.
COVID-19
Neurocognitive Impairment in Long COVID: A Systematic Review
Of the 516 studies assessed for eligibility, 36 studies met the inclusion criteria. All included studies support the presence of persistent cognitive changes after COVID-19 disease. Executive function, memory, attention, and processing speed appear to be the cognitive domains that are predominantly associated with long-COVID syndrome, whereas language is an area that has not been sufficiently investigated.
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
SARS-CoV-2 causes vascular dysfunction by stiffening endothelial cells, even without fully replicating in them. This applies to multiple variants (Alpha, Beta, Delta). This stiffening (loss of elasticity) disrupts blood flow regulation, promotes inflammation, and increases clotting risk. The study highlights endothelial dysfunction as a direct viral effect, not just due to systemic inflammation or cytokines.
Mid and long-term neurological and neuropsychiatric manifestations of…
Researchers analyzed 18 studies covering 10,530 patients to assess neurological and mental health symptoms after COVID-19. The most common symptoms were fatigue (37%), brain fog (32%), memory problems (28%), attention issues (22%), muscle pain (17%), loss of smell (12%), taste changes (10%), and headaches (15%). Mental health symptoms included sleep disturbances (31%), anxiety (23%), and depression (17%), which became more common over time
Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection | PNAS
As severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections have been shown to affect the central nervous system, the investiga...
MSK Library Guides: COVID Impacts: Cardiovascular
"While COVID-19 is considered a "respiratory virus", it manifests through the entire body. Cardiovascular complications have been well-documented in acute COVID-19 infection, and recent research is showing that it also causes significant cardiovascular manifestations in the post-acute phase of the disease."
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
This long-term study suggests that individuals recovering from COVID-19 continue to experience cognitive complaints, psychiatric and neurological symptoms, and brain functional alteration. The MRI results indicated that the changes in brain function in regions such as the putamen, temporal lobe, and superior parietal gyrus may contribute to cognitive complaints in individuals with long COVID even 2 years after acute infection.
Developmental impairment in children exposed during pregnancy to maternal SARS-COV2: A Brazilian cohort study
20.3% of children whose mothers had Covid during pregnancy and 5.9% of the control group received a diagnosis of neurodevelopmental delay within 12 months of life.
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Researchers at Children’s Hospital of Philadelphia (CHOP) have found elevated levels of a biomarker related to blood vessel damage in children with SARS-CoV-2 infection, even if the children had minimal or no symptoms of COVID-19. They also found that a high proportion of children with SARS-CoV-2 infection met clinical and diagnostic criteria for thrombotic microangiopathy (TMA). TMA is a syndrome that involves clotting in the small blood vessels and has been identified as a potential cause for severe manifestations of COVID-19 in adults.
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
People with long COVID have symptoms such as pain, extreme fatigue and “brain fog,” or difficulty concentrating or remembering things. As of March 2023, the syndrome was estimated to affect more than 15 million adults in the U.S., and a 2022 report found that it had forced between two million and four million Americans out of the workforce. Long COVID often arises in otherwise healthy young people, and it can follow even a mild initial infection.
Do Repeat COVID Infections Increase the Risk of Severe Disease or Lon…
Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19
Examining data in over 1 million children from medical records, the incidence of type I diabetes diabetes was increased 2x among those infected with COVID-19 in the first 3 months post-COVID, but risk remained elevated up to 15 months compared to those without a diagnosis of COVID.
Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19
![Long COVID impacting more than 1 million [American] children: CDC study suggests](https://rdl.ink/render/https%3A%2F%2Fs.abcnews.com%2Fimages%2FHealth%2Flong-covid-kids-as-jm-250203_1738592744610_hpMain_16x9_992.jpg?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2)
Long COVID impacting more than 1 million [American] children: CDC study suggests
More than 1 million American children were affected by Long Covid in 2023 alone.
Sex Differences in Long COVID
Cohort study of 12,276 people found female sex is associated with 31% increased risk of LongCovid. the risk was highest in the 40-55 age group of non-menopausal women.
Covid may increase the risk of heart attacks, strokes, and deaths for three years after an infection, a new study suggests | CNN
Covid-19 continues to be a powerful risk factor for future heart attacks and strokes for almost three years following the infection, a large new study suggests.
CDC Says About 20% Get Long COVID. New Models Try to Define It
New research is not only helping to define how many people may have long COVID, but also helping to find the tools to properly define exactly what the condition is -- and isn't.
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) based on self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections using a cohort of adults with and without SARS-CoV-2 infection.
Nearly One in Five American Adults Who Have Had COVID-19 Still Have "Long COVID"
National Center for Health Statistics
Long COVID science, research and policy
Nature Medicine - This Review outlines the current state of scientific evidence on long COVID, discusses its impacts on patients, health systems, economies and global health metrics, and proposes a...
Experiences of Canadians with long-term symptoms following COVID-19
This study uses data from the Canadian COVID-19 Antibody and Health Survey to describe the current COVID-19 landscape, including infection, reinfection, and acute and long-term symptoms. This study also examines how peoples’ experiences with the virus have evolved in the context of growing immunity, emerging variants, new treatments, and relaxation of public health measures.
Understanding Cumulative Risk
"Two years ago, one of us made a prediction in Fortune Magazine that a few years of ‘learning to live with’ COVID (i.e., pretending it doesn’t exist) would lead to a billion cases of Long COVID. A recent estimate pegs the total incidence so far at 400 million cases of Long COVID. Long COVID is well on its way to becoming the world’s most common disease."
Does COVID increase the risk of Alzheimer’s disease?
COVID-19, even in mild cases, is linked to changes in Alzheimer’s disease-related brain biomarkers comparable to four years of aging. This study raises concerns about long-term neurological risks and cognitive decline post-COVID.
I Love You. Please Find Someone Else. - The New York Times
I had heard of the life-altering fatigue of long Covid, which turned doing the dishes into a marathon requiring several breaks and a nap. I didn’t know, however, that the illness would trigger in me a painful allergic reaction to sunshine, or trigeminal neuralgia (imagine wearing an electric fishnet as a mask), or the dozen other bizarre symptoms that left me feeling as if an essential screw holding me together had come loose.
I became housebound overnight. I was 37. Loving your partner “in sickness” sounds noble, romantic even. In reality, it’s gut wrenching.
SARS-CoV-2 evolution on a dynamic immune landscape
Nature - A modelling approach predicts SARS-CoV-2 variant dynamics on the basis of immunity and cross-neutralization, which was shaped by a region’s SARS-CoV-2 infection history.
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
Around 11.6% of toddlers born to mothers with lab-confirmed SARS-CoV-2 infection during pregnancy showed cognitive, motor, or language problems indicative of neurodevelopmental delays. By comparison, only two of 128 unexposed controls — 1.6% — showed such issues.
Missing the gig: When your subculture leaves you behind with Long COVID - The Sick Times
“I thought our deal was fuck the state, we’ll do it our way. I found myself slipping through the subcultural safety net that exists for outcasts who are slipping through the cracks of mass culture and late capitalism.”
The “pandemic of abandonment”: Navigating friendships five years into COVID-19 - The Sick Times
"It is very common for people with Long COVID and those taking COVID-19 precautions to experience grief over lost intimacy with friends. Since ableism is so embedded in our society, friends who are just doing what everyone else does are moving in accordance with that ableism."
Long Covid: A parallel pandemic
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