COVID-19

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Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Many of Covid’s earliest and most alarming effects involve the brain, including a lost sense of smell, sluggish thinking, headaches, delirium and strokes. More than four years after the pandemic began, researchers are recognizing the profound impacts Covid can have on brain health, as millions of survivors suffer from persistent issues such as brain fog, depression and cognitive slowing, all of which hinder their ability to work and otherwise function. Scientists now worry that these symptoms may be early indicators of a coming surge in dementia and other mental conditions, prolonging the pandemic’s societal, economic and health burden.
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
This paper dives deep into the complexities of cognitive dysfunction in people with Long COVID—what many call “brain fog” but what is actually a much more debilitating symptom. It’s not just about forgetting where you left your keys; it’s about struggling to work, parent, or even read without triggering post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even minor physical, cognitive, or emotional effort.
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
This review investigates key pathophysiological mechanisms contributing to cerebrovascular dysfunction in long COVID and their impacts on brain health. We discuss how endothelial tropism of SARS-CoV-2 and direct vascular infection trigger endothelial dysfunction, impaired neurovascular coupling, and blood–brain barrier disruption, resulting in compromised cerebral perfusion. Furthermore, the infection appears to induce mitochondrial dysfunction, enhancing oxidative stress and inflammation within cerebral endothelial cells. Autoantibody formation following infection also potentially exacerbates neurovascular injury, contributing to chronic vascular inflammation and ongoing blood–brain barrier compromise. These factors collectively contribute to the emergence of white matter hyperintensities, promote amyloid pathology, and may accelerate neurodegenerative processes, including Alzheimer’s disease.
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Lancet study shows extreme increases in strokes, seizures, cognitive deficits (including dementia), psychotic disorders and brain swelling in kids and young people 2 years after acute infection.
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study - Italian Journal of Pediatrics
The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study - Italian Journal of Pediatrics
Background The effect of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus in the neonatal period on developing brain is still unknown. This study aims to investigate the long-term neurodevelopmental outcomes of newborns exposed to SARS-CoV-2 & Delta variant. Methods At a tertiary referral center, a prospective observational cohort research was carried out. All babies who were equal to or more than 34 gestational weeks gestation and were admitted to the NICU between January 2021 and January 2022 due to SARS-CoV-2 infection (Delta - or Delta +) were included in the study. Infants who were hospitalized for non-SARS-CoV-2 reasons at similar dates and who had no history of invasive mechanical ventilation were incorporated as a control group using a 2:1 gender and gestational age match. Thirty infants were assigned to the study group and sixty newborns to the control group based on the sample size calculation. These toddlers’ neurodevelopment was evaluated between the ages of 18 and 24 months using the Bayley-II scale. Results We enrolled 90 infants. SARS-CoV-2-positive infants had poorer psychomotor development index (PDI) scores and significantly greater mildly delayed performances (MDPs) at 18–24 months (PDI p = 0.05, MDPs p = 0.03, respectively). Delta variant showed statistically significant lower MDI and PDI scores (MDI p=0.03, PDI p=0.03, respectively). A smaller head circumference of SARS-CoV-2-positive toddlers was detected in the first year (p
The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study - Italian Journal of Pediatrics
Cardiopulmonary Exercise Testing in Children With Long... : The Pediatric Infectious Disease Journal
Cardiopulmonary Exercise Testing in Children With Long... : The Pediatric Infectious Disease Journal
VID (LC), while the evidence about its role in children with this condition is scarce. Methods: Prospective, case-controlled observational study. Children with LC and a control group of healthy children underwent CPET. CPET findings were compared within the 2 groups, and within the LC groups according to main clusters of persisting symptoms. Results: Sixty-one children with LC and 29 healthy controls were included. Overall, 90.2% of LC patients (55 of 61) had a pathologic test vs 10.3% (3/29) of the healthy control. Children with LC presented a statistically significant higher probability of having abnormal values of peak VO2 (P = 0.001), AT% pred (P
Cardiopulmonary Exercise Testing in Children With Long... : The Pediatric Infectious Disease Journal
Scientists alarmed by COVID’s diabetes link, particularly in children
Scientists alarmed by COVID’s diabetes link, particularly in children

"When Ziyad Al-Aly’s research team told him how often diabetes appeared to strike Covid-19 survivors, he thought the data must be wrong, so he asked his five colleagues to crunch the numbers again.

Weeks later, they returned the same findings after sifting through millions of patient records. By then Al-Aly had also gone digging into the scientific literature and was starting to come to terms with an alarming reality: Covid-19 isn’t just deadlier for people with diabetes, it’s also triggering the metabolic disease in many who didn’t previously have it."

Scientists alarmed by COVID’s diabetes link, particularly in children
Effect of COVID-19 infection on psychological aspects of pre-schooler children: a cross-sectional study - Middle East Current Psychiatry
Effect of COVID-19 infection on psychological aspects of pre-schooler children: a cross-sectional study - Middle East Current Psychiatry
Background Coronavirus disease 2019 (COVID-19) had a tremendous effect on individual’s lives worldwide. The pandemic’s significant socioecological impact is one of the many burdens children confront in the current crises. As a result, this study was designed to determine the psychological impacts of the COVID-19 pandemic on preschoolers, particularly the consequences of COVID-19 infection. This study involved 138 children aged 2–5.11 years old who were classified into two groups based on their COVID-19 infection history, which was documented via a PCR test. All participants were assessed by the Socioeconomic Scale and The Children’s Behavior Checklist (CBCL). Results COVID-19 infection was found in 21.7% of the children who participated in this study. Furthermore, children with COVID-19 had a higher percentage of clinical rating on the CBCL Profile of DSM-5 scales for affective problems (13.3 vs. 7.4%), anxiety problems (13.3 vs. 9.3%), pervasive developmental problems (20 vs. 13%), and oppositional defiant problems (6.7 vs. 5.6%) than children without COVID-19. Anxiety and somatic problems had a positive correlation with the impact of the COVID-19 pandemic on the lives of children. Conclusions Children infected with COVID-19 were more likely to have psychological issues, such as affective disorders, anxiety problems, pervasive developmental problems, and oppositional defiant problems. These psychological issues had a relationship with the impact of the COVID-19 pandemic on the lives of children.
Effect of COVID-19 infection on psychological aspects of pre-schooler children: a cross-sectional study - Middle East Current Psychiatry
Up to 5.8 million [American] kids have long COVID, study says. One mother discusses the "heartbreaking" search for answers.
Up to 5.8 million [American] kids have long COVID, study says. One mother discusses the "heartbreaking" search for answers.

Up to 5.8 million [American] young people have long COVID, according to a recent study — and parents like Amanda Goodhart are looking for answers.

She says her 6-year old son Logan caught COVID multiple times. But even months later, his symptoms didn't get better.

"To see him struggle to stay awake, or crying and saying he doesn't feel good, it's heartbreaking, it's demoralizing, because there's not a lot of treatment options," she told CBS News.

Study author Dr. Rachel Gross of NYU's Grossman School of Medicine says one major challenge in tracking the illness is that symptoms can vary.

"Long COVID can look different in different children, that not everybody has the same symptoms and that it can look different depending on when the symptoms start," she says.

Up to 5.8 million [American] kids have long COVID, study says. One mother discusses the "heartbreaking" search for answers.