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Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. Ivermectin, an antiparasitic drug, has been shown to possess anti-inflammation, anti-virus, and antitumor properties. However, whether ivermectin affects CRC is still unclear. The objective of this study was to evaluate the influence of ivermectin on CRC using CRC cell lines SW480 and SW1116. We used CCK-8 assay to determine the cell viability, used an optical microscope to measure cell morphology, used Annexin V-FITC/7-AAD kit to determine cell apoptosis, used Caspase 3/7 Activity Apoptosis Assay Kit to evaluate Caspase 3/7 activity, used Western blot to determine apoptosis-associated protein expression, and used flow cytometry and fluorescence microscope to determine the reactive oxygen species (ROS) levels and cell cycle. The results demonstrated that ivermectin dose-dependently inhibited colorectal cancer SW480 and SW1116 cell growth, followed by promoting cell apoptosis and increasing Caspase-3/7 activity. Besides, ivermectin upregulated the expression of proapoptotic proteins Bax and cleaved PARP and downregulated antiapoptotic protein Bcl-2. Mechanism analysis showed that ivermectin promoted both total and mitochondrial ROS production in a dose-dependent manner, which could be eliminated by administering N-acetyl-l-cysteine (NAC) in CRC cells. Following NAC treatment, the inhibition of cell growth induced by ivermectin was reversed. Finally, ivermectin at low doses (...

Clearly in 2021, Australia has simply been returning to its roots as the world’s largest prison...

Buried on page 168 of the House Democrats’ 2,465-page mega bill is a tenfold increase in fines for employers that “willfully,” “repeatedly,” or even seriously violate a section of labor law that deals with hazards, death, or serious physical harm to their employees.

A plan devised by the Canadian Joint Operations Command relied on propaganda techniques similar to those employed during the Afghan war...

ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero

“These guys are not anti-vax, they just - given the extraordinarily low risk of COVID to them and the substantial risk of unknown long-term effects of the vaccine - they aren’t comfortable with it right now,”

"In other news, Pfizer is testing Ivermectin, now renamed PF-07321332, to help with Covid..."

“It has been 561 days since we introduced the toughest measures in Norway in peacetime... Now the time has come to return to a normal daily life.”

"Big Tech does not have the authority to police the expressions of people whose political viewpoint they simply disagree with..."

That's not how this is supposed to work...

One power company said it expected the power cuts to last until spring next year, and that unexpected outages would become "the new normal." Its post, however, was later deleted.

"The broader implications could be another "shock wave through the global tech and automotive supply chain..."

The Deep State has appeared to still be firmly opposed to President Trump amid the speculation of his possible run for presidency in 2024. In an ABC interview on Sunday, former senior DHS official Brian Murphy accused the 45th president of "spreading disinformation" and "posing an alleged threat to democracy."

Police "effectively ordered" to let junkies roam free, shooting up in broad daylight...

...'religions' aren’t susceptible to argument... but if you are fortunate enough to find yourself in a real argument, here’s an invaluable resource...

"The public interest is, unquestionably, best served by stopping the spread of the virus...", Judge Jackie Cowin said...

Under Obama, the CIA wanted to define Julian Assange and other journalists as “information brokers” in order to ramp up their spying on them. And during the Trump era, it prepared plans to abduct or kill the WikiLeaks founder.

A task force of senior scientists investigating the origins of Covid-19 has been disbanded, their leader revealed. Its investigation had been plagued from the outset by accusations of corruption and conflict of interest.

Yes, we need a Great Reset. Just not the subscription-based version that the World Economic Forum imagined... "Just Say No to Drugs"

Maybe it's time for California to admit their "green" push has been a complete disaster?

On Friday, Congressman Madison Cawthorn (R-N.C.) announced plans to introduce legislation to prohibit the U.S. military code from placing restrictions on servicemembers’ right to bear firearms. The bill, entitled the Protect Gun Rights Act, targets Democrat efforts to strip servicemembers’ rights to keep and bear arms through red flag laws.