Evolutionary origin and population diversity of a cryptic hybrid pathogen
Covid19-Sources
Fibrin drives thromboinflammation and neuropathology in COVID-19
Estimating Re and overdispersion in secondary cases from the size of identical sequence clusters of SARS-CoV-2
The post-pandemic hospital and mortality burden of COVID-19 compared with influenza: A national cohort study in Denmark, May 2022 to June 2024
Rates of Sudden Unexpected Infant Death Before and During COVID-19
Chronic lung inflammation and CK14+ basal cell proliferation induce persistent alveolar-bronchiolization in SARS-CoV-2-infected hamsters
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Covid-19: Neue Röntgentechnik zeigt Gefäßschäden in der Lunge
Covid-19 schädigt das Herz bis in die kleinsten Gefäße
SARS-CoV-2 specific plasma cells acquire long-lived phenotypes in human bone marrow
Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates
The influence of COVID-19 on short-term mortality in acute... : Medicine
Altered functional brain connectivity, efficiency, and information flow associated with brain fog after mild to moderate COVID-19 infection
Heart attacks among young adults doubled post-Covid: Study
Besorgniserregender Anstieg von Herzinfarkten bei jungen Erwachsenen nach COVID-19
Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019 - PubMed
Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19 - PubMed
Immunschutz durch langlebige Plasmazellen nach mRNA Impfung
Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
As it was shown, mRNA vaccination might not help for long, infection does neither.
SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination
Nature MedicineArtice https://doi.org/10.1038/s41591-024-03278-ytetanus vaccine. S2P IgA ASCs were also detected predominantly in PopAand PopB: a mean of 1.5% (1.46 ± 1.57) and 0.9% (0.90 ± 0.66), respec-tively, and were virtually absent in PopD: a mean of 0.03% (0.03 ± 0.06)(Extended Data Fig. 3b). On average, the fold changes of IgA ASC spe-cificities within PopD were 50.9 for Flu:S2P and 9.3 for Tet:S2P (Supple-mentary Table 3). For S2P specificity, the fold change of PopA:PopD was43.8 and of PopB:PopD was 27.0 (Supplementary Table 4). Thus, similarto IgG ASCs, other class-switched isotypes such as S2P IgA ASC are alsomostly excluded from PopD (albeit small sample size).Absence of SARS-CoV-2-specific IgG in LLPC culturesupernatantTo validate the antigen-specific ELISpot results, we measured secretedIgG from BM ASC subsets (Fig. 2a; see also Methods). Briefly, from eightindividuals who yielded sufficient sorted cells for all BM ASC subsets(PopA, PopB and PopD), we cultured ASCs in a specialized in vitro BMmimetic system overnight 16 and measured the cultured supernatantsfor secreted IgG specific for Flu, Tet and S2P by multiplex bead-bindingassays (MBBAs)34 (Extended Data Fig. 4). The results were similar to thePopAPopBPopDPopAPopBPopDPopAPopBPopDPopAPopBPopDPopAPopBPopDPopAPopBPopD0246810121416BM ASC in cultureBM Flu-, Tet-, S2P-IgGASC (% total)Purple: TetGreen: S2PBlue: FluFlu Tet S2PFlu Tet S2P0131323330.61 0.4429.07Non-LLPC:LLPC ratio, IgG ASC013132333Non-LLPC:LLPC ratio, sup IgGPurple: TetGreen: S2PBlue: Flu0246713192531BM ASC in cultureSup Flu-, Tet-, S2P-IgG (% total)0.66 0.4423.26PopD PopB PopASub 8Total S2PFlu TetLLPC Non-LLPCELISpotCellsMBBASupSorting forBM ASCBM donorsASC culture(overnight)BM MNC PopA, PopB andPopD (LLPC)ASC survivalmediumBM collectionand MNC isolationa bc de fBM ASCBM ASC supFig. 2 | Absence of SARS-CoV-2 BM IgG LLPC after SARS-CoV-2 mRNA vaccinesby detection of ASC and secreted IgG in the BM ASC culture supernatants.a, Summary of the techniques and the experimental designs for detection oftotal, Flu, Tet and S2P ASCs and secreted IgG by ELISpots and MBBA, respectively.MNC, mononuclear cells. b, Representative ELISpot scanned images. Thenumbers of input ASC that were incubated were ~52 K, ~12.1 K and ~10.1 K forPopA, PopB and PopD, respectively. Each symbol represents an individualvaccine subject for total IgG and antigen-specific ASC from PopA, PopB andPopD. c, ELISpots measuring BM IgG ASC specific for Flu, Tet and S2P. Data weregenerated from 8, 15 and 17 different SARS-CoV-2-vaccinated subjects for PopA,PopB and PopD, respectively. For individual ratios and statistic comparisonsbetween any two antigens for any subset or between any two subsets for anyantigen, see Supplementary Tables 1 and 2, respectively. d, Fold difference(ratios) when comparing different vaccine specificities between non-LLPCs(combined PopA and PopB) versus LLPCs (PopD). e, MBBA measuring IgGspecific for Flu, Tet and S2P (normalized to total IgG) from culture supernatant ofPopA, PopB and PopD. Supernatant preps were collected from 18–24-h culturesof BM ASCs after revival from the FACS sorters and were quantified for total IgGand vaccine-specific IgG in neat (undiluted). Data were generated from eightdifferent SARS-CoV-2-vaccinated subjects. For individual ratios and statisticcomparisons between any two antigens for any subset or between any twosubsets for any antigen, see Supplementary Tables 1 and 2, respectively. f, Thefold difference (ratios) when comparing normalized vaccine-specific IgG in thesupernatants from the culture of non-LLPCs (combined PopA and PopB) versusLLPCs (PopD). For ratio calculation, see Methods. For IgG standard versus MFIcurve, see Extended Data Fig. 4. Counts were provided by the sorters. LLPC, boxesin b, c, and e. Sub, subject; Sups, BM ASC culture supernatant preps. For details ofsubjects and samples, see Table 1.
Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT
Complemtary to this japanese paper.
Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients | Radiology
Interesting. Differences disappear 180 days after 2nd vaccination. No check with infected. Not clear if there are hidden infections.
Covid-19-Impfung reduziert Herzinfarkt. und Schlaganfallrisiko stark
Cardiac manifestations and outcomes of COVID-19 vaccine-associated myocarditis in the young in the USA: longitudinal results from the Myocarditis After COVID Vaccination (MACiV) multicenter study
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling - Nature Communications
Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases
Frontiers | Myocarditis in SARS-CoV-2 infection vs. COVID-19 vaccination: A systematic review and meta-analysis
COVID gefährdet Schwangerschaften, Neugeborene und Kinder überhaupt.
Brain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain
Does COVID-19 damage the brain? - Harvard Health