Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections
Covid19-Sources
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
This analysis of 2-year retrospective cohort studies of individuals diagnosed with COVID-19 showed that the increased incidence of mood and anxiety disorders was transient, with no overall excess of these diagnoses compared with other respiratory infections. In contrast, the increased risk of psychotic disorder, cognitive deficit, dementia, and epilepsy or seizures persisted throughout. The differing trajectories suggest a different pathogenesis for these outcomes. Children have a more benign overall profile of psychiatric risk than do adults and older adults, but their sustained higher risk of some diagnoses is of concern. The fact that neurological and psychiatric outcomes were similar during the delta and omicron waves indicates that the burden on the health-care system might continue even with variants that are less severe in other respects. Our findings are relevant to understanding individual-level and population-level risks of neurological and psychiatric disorders after SARS-CoV-2 infection and can help inform our responses to them.
Deaths by vaccination status, England - Office for National Statistics
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An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion
One for All?
Jährlicher Krankenstand in Deutschland bis 2022 | Statista
Rate of SARS-CoV-2 Reinfection During an Omicron Wave in Iceland
Surprisingly, 2 or more doses of vaccine were associated with a slightly higher probability of reinfection compared with 1 dose or less. This finding should be interpreted with caution because of limitations of our study, which include the inability to adjust for the complex relationships among prior infection, vaccine eligibility, and underlying conditions. Importantly, by December 1, 2021, all persons aged 12 years and older were eligible for 2 or more vaccine doses free of charge, and 71.1% of the Icelandic population had been vaccinated,5 compared with only 25.5% of our cohort of previously infected persons.
SARS-CoV2-assoziierte Veränderungen der Hirnstruktur im Langzeitverlauf bei nicht-hospitalisierten Personen - Deutsche Gesellschaft für Neurologie e. V.
Michael (Mike) Meier on Twitter
Wirkung von Antikörpern gegen Omikron-Varianten BA.1 und BA.2 lässt schnell nach | Aktuelles aus der Goethe-Universität Frankfurt
Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age | NEJM
A Negative COVID Test Has Never Been So Meaningless
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Aggressive Presentation and Rapid Progression of Osteonecrosis of the Femoral Head After COVID-19 - PubMed
Impact of Lifting School Masking Requirements on Incidence of COVID-19 among Staff and Students in Greater-Boston Area School Districts: A Difference-in-Differences Analysis
SARS-CoV-2 Variant Vaccine Boosters Trial: Preliminary Analyses
Impfstoffforscher über Corona-Herbst: „Man kann leider noch keine vollständige Entwarnung geben“
„In der Kinderkardiologie und -pneumologie überflutet uns Long-Covid“
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Tyler Black, MD on Twitter
Tyler Black, MD on Twitter
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5
Duration of BA.5 neutralization in sera and nasal swabs from SARS-CoV-2 vaccinated individuals, with or without Omicron breakthrough infection
Symptoms and risk factors for long COVID in non-hospitalized adults
A total of 62 symptoms were significantly associated with SARS-CoV-2 infection after 12 weeks. The largest aHRs were for anosmia (aHR 6.49, 95% CI 5.02–8.39), hair loss (3.99, 3.63–4.39), sneezing (2.77, 1.40–5.50), ejaculation difficulty (2.63, 1.61–4.28) and reduced libido (2.36, 1.61–3.47). Among the cohort of patients infected with SARS-CoV-2, risk factors for long COVID included female sex, belonging to an ethnic minority, socioeconomic deprivation, smoking, obesity and a wide range of comorbidities. The risk of developing long COVID was also found to be increased along a gradient of decreasing age. SARS-CoV-2 infection is associated with a plethora of symptoms that are associated with a range of sociodemographic and clinical risk factors.
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8+ T cells