Kinder entwickeln nach SARS-CoV-2-Infektion vermehrt...
Covid19-Sources
Corona: Pandemie begann doch im Wildtiermarkt
René on Twitter
Lebenserwartung in Deutschland seit Beginn der Pandemie gesunken
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcomes with coronavirus disease 2019 (COVID-19) is that the immune response to the SARS-CoV-2 spike protein is enriched for antibodies directed against epitopes shared with endemic beta-coronaviruses and has a lower proportion of antibodies targeting the more protective variable regions of the spike. The magnitude of antibody responses to the SARS-CoV-2 full-length spike protein, its domains and subunits, and the SARS-CoV-2 nucleocapsid also correlated strongly with responses to the endemic beta-coronavirus spike proteins in individuals admitted to an intensive care unit (ICU) with fatal COVID-19 outcomes, but not in individuals with nonfatal outcomes. This correlation was found to be due to the antibody response directed at the S2 subunit of the SARS-CoV-2 spike protein, which has the highest degree of conservation between the beta-coronavirus spike proteins. Intriguingly, antibody responses to the less cross-reactive SARS-CoV-2 nucleocapsid were not significantly different in individuals who were admitted to an ICU with fatal and nonfatal outcomes, suggesting an antibody profile in individuals with fatal outcomes consistent with an “original antigenic sin” type response.
🇺🇦 Meaghan Kall on Twitter
Surgery delays ramp up amid rise in post-viral complications
Acute Myocardial Infarction and Ischemic Stroke After COVID-19 by Vaccination Status
Wolfgang Hagen 💉🚴🏻♂️🇪🇺 on Twitter
Corona: Was die Haut verrät
COVID-19-Erkrankung: Wenn die Haut ein Spiegel der SARS-CoV-2-Infektion ist
DGUV: Zahlen und Fakten - BK-Geschehen
Ungeimpfte mit höchsten COVID-19-Hospitalisierungsinzidenzen
Höchster Krankenstand in Deutschland: Warum?
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients
Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection | NEJM
Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK
Dr Zoë Hyde on Twitter
So, Long Covid
Omicron Boosters and Original Antigenic Sin
jorgenponder — om coronavirusepidemin on Twitter
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines
Prof. Shane Crotty on Twitter
The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study
Long-COVID in Children and Adolescents: A Systematic Review and Meta-analyses
COVID Data Tracker
America Was in an Early-Death Crisis Long Before COVID
Service suche form: Paxlovid