Fibromyalgia

Fibromyalgia

"#mitochondrial dysfunction"
Mitochondrial Enhancers for ME/CFS and Fibromyalgia Pt IV: N-Acetyl Cysteine (NAC) - Health Rising
Mitochondrial Enhancers for ME/CFS and Fibromyalgia Pt IV: N-Acetyl Cysteine (NAC) - Health Rising
This is bookmarked because FMS symptoms like mitochondrial dysfunction and ischemia overlap with those of ME/CFS. Interesting choice of supplement suggestions backed with research.
N-acetyl cysteine or NAC is a most interesting compound. Most often thought of as an antioxidant it appears to be able to enhance mitochondrial production as well. Perhaps the most powerful antioxidant available and certainly the most widely studied, NAC is able to rejuvenate the levels of glutathione – the most powerful antioxidant in the body. It appears to do its work mostly in the mitochondria where recent research indicates it also triggers the production of hydrogen sulfide which, in turn, produces antioxidant effects and perhaps enhances ATP production as well.
A 2019 hypothesis paper proposed that supplements like coenzyme Q10, melatonin, curcumin, molecular hydrogen, and N-acetylcysteine could be helpful in ME/CFS patients with inflammation, increased oxidative and nitrosative stress, leaky gut, and mitochondrial dysfunction.
Shungu, interestingly, does not believe ME/CFS is a mitochondrial disorder. The mitochondria are affected in ME/CFS but at its heart, Shungu believes ME/CFS is an oxidative stress-induced micro-circulatory disease. High levels of oxidative stress are causing the blood vessels to shut down, making it impossible for the oxygen the mitochondria need to get through. Shungu’s hypothesis, which was produced some time ago, is circling around the same blood flow issues that other hypotheses are.
·healthrising.org·
Mitochondrial Enhancers for ME/CFS and Fibromyalgia Pt IV: N-Acetyl Cysteine (NAC) - Health Rising
Transcranial Photobiomodulation for Fibromyalgia, Clinical Case Reports Journal, ISSN 2767-0007
Transcranial Photobiomodulation for Fibromyalgia, Clinical Case Reports Journal, ISSN 2767-0007
Exciting! I have a device that emits IR and near IR. Note that ATP production would be wonderful for fibromyalgia.
·clinicalcasereportsjournal.com·
Transcranial Photobiomodulation for Fibromyalgia, Clinical Case Reports Journal, ISSN 2767-0007
Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice - PubMed
Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice - PubMed

Many participants had fibromyalgia in this study, and had fatigue and exercise intolerance. Study points to underlying metabolic disease.

·pubmed.ncbi.nlm.nih.gov·
Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice - PubMed
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Suggests metabolic syndrome involvement and mitochondrial dysfunction in fibromyalgia development
·sciencedirect.com·
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Some suggest insulin resistance as a cause of fibromyalgia
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
·sciencedirect.com·
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance
Mitochondrial dysfunction involvement in fibromyalgia
·ncbi.nlm.nih.gov·
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance