#research #Inflammation #study #neuroinflammation

Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation

Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse model ...

reduced proinflammatory factor (IL-1β, TNF-α, and IL-6) production, and increased the expression of anti-inflammatory factors (IL-10).

This probably speaks to its role in combating pain in FMS.

Modafinil treatment attenuated inflammasome activity and reduced neuronal pyroptosis involving the NLRP3/NLRP1/NLRC4-caspase-1-IL-1β pathway

IL-1β

IL-6

TNF-α

#research #modafinil #neuroinflammation #brain #inflammation #fibromyalgia #study

·ncbi.nlm.nih.gov·Sep 14, 2024

Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

In addition to central hyperexcitability and impaired top–down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the ...

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

#study #inflammation #systemic inflammation #neuroinflammation #fibromyalgia #research

·ncbi.nlm.nih.gov·Aug 10, 2024

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma