Fibromyalgia

Fibromyalgia

#fibromyalgia #research "#structural evidence"
Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia
Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia
Objective In patients with fibromyalgia (FM), the brain shows altered structure and functional connectivity, but the mechanisms underlying these changes remain unclear. This study investigated the associated changes in brain microstructures and neuroinflammation of patients with FM. Methods We recruited 14 patients with FM and 14 healthy controls (HCs). Visual analog scale (VAS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II) were used for assessing their pain, anxiety, and depression levels, respectively. Diffusion kurtosis imaging (DKI) was used to visualize microstructural alterations associated with neuroinflammation in specific brain regions. The biomarkers for neuron damage, including serum tau and amyloid β protein fragment 1-42 (Aβ1-42) levels, were assessed. Spearman correlation of DKI parameters with VAS, BAI, and BDI-II scores as well as tau and Aβ1-42 levels were assessed. Results The patients with FM had significantly higher levels of Aβ1-42 levels than HCs. Compared with HCs, the patients with FM showed significantly lower DKI parameters in the bilateral dorsolateral prefrontal cortex and orbitofrontal cortex. Patients with FM showed a significant correlation between the axial kurtosis values of the amygdala and VAS scores (left: ρ = −0.60, P = 0.02; right: ρ = −7.04, P = 0.005). Conclusion To the best of our knowledge, this is the first study to use DKI to examine the brains of patients with FM. We noted significant DKI changes associated with neuroinflammation at specific areas in patients with FM. Our results provide valuable information on brain neuroinflammation and pathophysiological changes in patients with FM.
Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia
·jrheum.org·
Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Get to know about the associated changes in neuroinflammation and brain microstructures of patients with fibromyalgia (FM).
microstructural abnormalities associated with neuroinflammation in specific brain areas
indicators for neuron damage
changes in brain microstructures and neuroinflammation in FM patients
·physiciansweekly.com·
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Despite different techniques, equipment, and statistical criteria, neuroimaging studies have been considerably consistent in the identification of brain regions involved in various pain related processes. Functional neuroimaging studies regularly identify activation differences in a stable set of brain regions between pain and control populations. Recent structural studies have reported similar gray matter abnormalities among multiple chronic pain populations. Yet, the findings from structural and functional imaging studies are not completely unified.
Together, these structural and functional imaging results suggest a functional plasticity of the brain circuitry that is consistent with theories of central sensitization, and may be a key factor in the development and/or maintenance of chronic pain.
·jpain.org·
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia ...
·ncbi.nlm.nih.gov·
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Structural alterations in brainstem of fibromyalgia syndrome patients correlate with sensitivity to mechanical pressure
Structural alterations in brainstem of fibromyalgia syndrome patients correlate with sensitivity to mechanical pressure
Fibromyalgia syndrome is a chronic pain disorder characterised by widespread pain and tenderness in muscles and deep tissues. Current theories regarding the pathophysiological origins of fibromyalgia syndrome point towards central sensitisation and a ...
Fibromyalgia syndrome patients exhibited shape alterations in the brainstem.•The mean brainstem volume was also significantly reduced in FMS patients.•This volume reduction correlated with clinical manual tender point scores.•Structural alterations in the brainstem may contribute to clinical symptoms of FMS.
·ncbi.nlm.nih.gov·
Structural alterations in brainstem of fibromyalgia syndrome patients correlate with sensitivity to mechanical pressure
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women - PubMed
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women - PubMed
Peripheral mechanisms, i.e., altered muscle fiber size distribution and decreased capillary density, may contribute to postexertional fatigue in FM. Understanding of these defects in fibromyalgic muscle may provide valuable insight with regard to treatment.
greater variability in fiber size and altered fiber size distribution
capillary density was lower in the FM group
However, self-reported fatigue and pain were correlated with prolonged loss of strength following 12 minutes of recovery in patients with FM.
·pubmed.ncbi.nlm.nih.gov·
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women - PubMed
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising
Exercise is highly recommended as an adjunct therapy in fibromyalgia. We’re not talking about pounding the pavement, however. A 2010 review of exercise studies found that ‘slight to moderate’ intensity aerobic exercise sessions done two to three times a week worked best, and that appropriate levels of exercise result in improved […]
At least as early as 2006, researchers suggested that muscle ischemia (low blood flows) both during and after exercise could be causing pain in FM and driving the central sensitization found
Indeed, some research suggests the normal muscle recruitment is not occurring in FM
Problems with the microcirculation could, therefore, be contributing to the aerobic energy problems, pain, and weakness found in FM.
·healthrising.org·
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising